Detail Information

Basic Information:


  VIRBase ID:  

VHID00518328

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           ILDR2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p ILDR2
miRBase
Accession/Entrez ID		 MIMAT0001581 387597
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - C1orf32//dJ782G3.1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ILDR2
chr1:166941386(-) A-I      intronic
chr1:166883151(-) A-I      3'UTR
chr1:166940898(-) A-I      intronic
chr1:166934988(-) A-I      intronic
chr1:166883186(-) A-I      3'UTR
chr1:166936899(-) A-I      intronic
chr1:166883136(-) A-I      3'UTR
chr1:166883150(-) A-I      3'UTR
chr1:166883132(-) A-I      3'UTR
chr1:166895903(-) A-I      intronic
chr1:166934948(-) A-I      intronic
chr1:166936894(-) A-I      intronic
chr1:166883275(-) A-I      3'UTR
chr1:166883269(-) A-I      3'UTR
chr1:166883188(-) A-I      3'UTR
chr1:166883230(-) A-I      3'UTR
chr1:166891465(-) A-I      intronic
chr1:166936872(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ILDR2
chr1:166883151(-) A-G exon 3'UTR    22484847
chr1:166934948(-) A-G intron -    22484847
chr1:166940898(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ILDR2
chr1:166877331-166877332(-) m6A exon       -
chr1:166885945-166885946(-) m6A 3'UTR//intron       22608085
chr1:166885965-166885966(-) m6A 3'UTR//intron       22608085
chr1:166886018-166886019(-) m6A 3'UTR//intron       22608085
chr1:166886029-166886030(-) m6A 3'UTR//intron       22608085
chr1:166886037-166886038(-) m6A 3'UTR//intron       22608085
chr1:166886053-166886054(-) m6A 3'UTR//intron       22608085
chr1:166886437-166886438(-) m6A 3'UTR//intron       25456834
chr1:166886445-166886446(-) m6A 3'UTR//intron       25456834
chr1:166886486-166886487(-) m6A 3'UTR//intron       25456834
chr1:166886987-166886988(-) m6A 3'UTR//intron       -
chr1:166887000-166887001(-) m6A 3'UTR//intron       -
chr1:166887033-166887034(-) m6A 3'UTR//exon       -
chr1:166887117-166887118(-) m6A 3'UTR//exon       27371828//22608085
chr1:166887127-166887128(-) m6A 3'UTR//exon       27371828//22608085
chr1:166887150-166887151(-) m6A 3'UTR//exon       27371828//22608085
chr1:166887201-166887202(-) m6A 3'UTR//exon       27371828//22608085
chr1:166887311-166887312(-) m6A 3'UTR//exon       22608085
chr1:166887842-166887843(-) m6A 3'UTR       22608085
chr1:166887888-166887889(-) m6A 3'UTR       22608085
chr1:166887961-166887962(-) m6A 3'UTR       24209618//25456834//24981863//27371828//22608085
chr1:166888017-166888018(-) m6A 3'UTR       25456834//24981863//27371828//22608085
chr1:166888184-166888185(-) m6A 3'UTR       24209618//24981863//22608085
chr1:166888245-166888246(-) m6A 3'UTR       24209618//24981863//22608085
chr1:166888253-166888254(-) m6A 3'UTR       24209618//24981863//22608085
chr1:166888289-166888290(-) m6A 3'UTR       24209618//24981863//22608085
chr1:166888295-166888296(-) m6A 3'UTR       24209618//24981863//22608085
chr1:166888360-166888361(-) m6A 3'UTR       24209618//24981863//22608085
chr1:166888419-166888420(-) m6A 3'UTR       24209618//25456834//24981863//27371828//22608085
chr1:166888506-166888507(-) m6A 3'UTR       24209618//25456834//27371828//22608085
chr1:166888521-166888522(-) m6A 3'UTR       24209618//25456834//27371828//22608085
chr1:166888535-166888536(-) m6A 3'UTR//CDS       24209618//25456834//27371828//22608085
chr1:166888540-166888541(-) m6A 3'UTR//CDS       24209618//25456834//22608085
chr1:166888549-166888550(-) m6A 3'UTR//CDS       24209618//25456834//22608085
chr1:166888555-166888556(-) m6A 3'UTR//CDS       24209618//25456834//22608085
chr1:166889945-166889946(-) m6A CDS//intron       24209618//22608085
chr1:166890318-166890319(-) m6A CDS//intron       27371828//27773536
chr1:166891943-166891944(-) m6A CDS//intron       -
chr1:166892003-166892004(-) m6A CDS//intron       -
chr1:166892026-166892027(-) m6A CDS//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ILDR2
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: ILDR2

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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