Basic Information:

  VIRBase ID:  

VHID00518240

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ZNF773:  NM_198542     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ZNF773
miRBase Accession/Entrez ID	MIMAT0001581	374928
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ZNF419B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF773	chr19:58019141(+) A-I      3'UTR chr19:58019142(+) A-I      3'UTR chr19:58019195(+) A-I      3'UTR chr19:58019160(+) A-I      3'UTR chr19:58019163(+) A-I      3'UTR chr19:58019165(+) A-I      3'UTR chr19:58019202(+) A-I      3'UTR chr19:58019296(+) A-I      3'UTR chr19:58019220(+) A-I      3'UTR chr19:58017217(+) A-I      intronic chr19:58019120(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF773	chr19:58017843-58017844(+) m6A CDS//intron       - chr19:58018095-58018096(+) m6A CDS//intron       24981863 chr19:58018901-58018902(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr19:58018917-58018918(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr19:58018933-58018934(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr19:58019001-58019002(+) m6A 3'UTR//intron       25456834//24981863//27773535//22608085 chr19:58019019-58019020(+) m6A 3'UTR//intron       24209618//25456834//24981863//27773535//22608085 chr19:58019057-58019058(+) m6A 3'UTR//intron       24209618//25456834//24981863//27773535//22608085 chr19:58019133-58019134(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr19:58019141-58019142(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr19:58019164-58019165(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr19:58019261-58019262(+) m6A 3'UTR//intron       24981863//22608085 chr19:58019312-58019313(+) m6A 3'UTR//intron       24981863//22608085 chr19:58019330-58019331(+) m6A 3'UTR//intron       24981863//22608085 chr19:58019429-58019430(+) m6A 3'UTR//intron       25456834//22608085 chr19:58019498-58019499(+) m6A 3'UTR//intron       25456834//22608085 chr19:58019525-58019526(+) m6A 3'UTR//intron       22608085 chr19:58024395-58024396(+) m6A CDS       22608085 chr19:58027476-58027477(+) m6A 3'UTR       - chr19:58027556-58027557(+) m6A 3'UTR       25456834//24981863 chr19:58027561-58027562(+) m6A 3'UTR       25456834//24981863 chr19:58027567-58027568(+) m6A 3'UTR       25456834//24981863 chr19:58027609-58027610(+) m6A 3'UTR       25456834//24981863 chr19:58027622-58027623(+) m6A 3'UTR       25456834//24981863 chr19:58027642-58027643(+) m6A 3'UTR       25456834//24981863 chr19:58027656-58027657(+) m6A 3'UTR       25456834//24981863 chr19:58027731-58027732(+) m6A 3'UTR       - chr19:58028953-58028954(+) m6A 3'UTR       24981863 chr19:58028974-58028975(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZNF773	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ZNF773

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.