Basic Information:

  VIRBase ID:  

VHID00518147

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          GEN1:  NM_001130009     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	GEN1
miRBase Accession/Entrez ID	MIMAT0001581	348654
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	Gen

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GEN1	chr2:17964540(+) A-I      3'UTR chr2:17960319(+) A-I      intronic chr2:17958318(+) A-I      intronic chr2:17958332(+) A-I      intronic chr2:17958381(+) A-I      intronic chr2:17958325(+) A-I      intronic chr2:17940006(+) A-I      intronic chr2:17937946(+) A-I      intronic chr2:17964454(+) A-I      3'UTR chr2:17940001(+) A-I      intronic chr2:17937955(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GEN1	chr2:17935223-17935224(+) m6A 5'UTR//exon       24981863 chr2:17941327-17941328(+) m6A CDS       24981863 chr2:17942664-17942665(+) m6A CDS//exon       24981863 chr2:17961380-17961381(+) m6A CDS//exon       22608085 chr2:17961905-17961906(+) m6A CDS//exon       24981863//22608085 chr2:17961918-17961919(+) m6A CDS//exon       24981863//22608085 chr2:17961960-17961961(+) m6A CDS//exon       24284625//24981863//22608085 chr2:17962104-17962105(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr2:17962125-17962126(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr2:17962368-17962369(+) m6A CDS       24284625//24209618//24981863//22608085 chr2:17962403-17962404(+) m6A CDS       24284625//24981863//22608085 chr2:17962567-17962568(+) m6A CDS       24284625//24981863//22608085 chr2:17962679-17962680(+) m6A CDS       24284625//24209618//24981863//22608085 chr2:17962700-17962701(+) m6A CDS       24284625//24209618//24981863//22608085 chr2:17962718-17962719(+) m6A CDS       24284625//24209618//24981863//22608085 chr2:17962771-17962772(+) m6A CDS       24284625//24209618//24981863//22608085 chr2:17962785-17962786(+) m6A CDS       24284625//24209618//24981863//22608085 chr2:17962831-17962832(+) m6A CDS       24284625//24209618//24981863//22608085 chr2:17962875-17962876(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr2:17962890-17962891(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr2:17963026-17963027(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr2:17963031-17963032(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr2:17963053-17963054(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr2:17963132-17963133(+) m6A CDS       24284625//24981863//22608085 chr2:17963184-17963185(+) m6A CDS       24284625//24981863//22608085 chr2:17963214-17963215(+) m6A 3'UTR       24981863//22608085 chr2:17963262-17963263(+) m6A 3'UTR       22608085 chr2:17963322-17963323(+) m6A 3'UTR       22608085 chr2:17964251-17964252(+) Y 3'UTR       26075521 chr2:17964902-17964903(+) m6A 3'UTR       24981863//27773535//22608085 chr2:17964984-17964985(+) m6A 3'UTR       24981863//27773535//22608085 chr2:17964998-17964999(+) m6A 3'UTR       24981863//27773535//22608085 chr2:17965019-17965020(+) m6A 3'UTR       24209618//24981863//27773535//22608085 chr2:17965030-17965031(+) m6A 3'UTR       24209618//24981863//27773535//22608085 chr2:17965157-17965158(+) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr2:17965171-17965172(+) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr2:17965257-17965258(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:17965262-17965263(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:17965273-17965274(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:17965280-17965281(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr2:17965318-17965319(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr2:17965369-17965370(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr2:17965395-17965396(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr2:17965418-17965419(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr2:17965538-17965539(+) m6A 3'UTR       24981863//27773535//22608085 chr2:17965546-17965547(+) m6A 3'UTR       24981863//27773535//22608085 chr2:17965749-17965750(+) m6A 3'UTR       22608085 chr2:17965767-17965768(+) m6A 3'UTR       24981863//22608085 chr2:17965820-17965821(+) m6A 3'UTR       24981863//22608085 chr2:17965853-17965854(+) m6A 3'UTR       24981863//27773535//22608085 chr2:17965905-17965906(+) m6A 3'UTR       24981863//27773535//22608085 chr2:17965932-17965933(+) m6A 3'UTR       24981863//22608085 chr2:17966207-17966208(+) m6A 3'UTR       24981863 chr2:17966312-17966313(+) m6A 3'UTR       24981863 chr2:17966324-17966325(+) m6A 3'UTR       24981863 chr2:17966392-17966393(+) m6A 3'UTR       24981863 chr2:17966437-17966438(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GEN1	Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: GEN1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.