Basic Information:

  VIRBase ID:  

VHID00517995

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ACER2:  NM_001010887     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ACER2
miRBase Accession/Entrez ID	MIMAT0001581	340485
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ALKCDase2//ASAH3L

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ACER2	chr9:19434612(+) A-I      intronic chr9:19434620(+) A-I      intronic chr9:19428977(+) A-I      intronic chr9:19443890(+) A-I      intronic chr9:19434621(+) A-I      intronic chr9:19439711(+) A-I      intronic chr9:19434651(+) A-I      intronic chr9:19443902(+) A-I      intronic chr9:19430687(+) A-I      intronic chr9:19416588(+) A-I      intronic chr9:19415443(+) A-I      intronic chr9:19439845(+) A-I      intronic chr9:19439890(+) A-I      intronic chr9:19416714(+) A-I      intronic chr9:19439710(+) A-I      intronic chr9:19439400(+) A-I      intronic chr9:19411508(+) A-I      intronic chr9:19430806(+) A-I      intronic chr9:19430805(+) A-I      intronic chr9:19430791(+) A-I      intronic chr9:19430825(+) A-I      intronic chr9:19430836(+) A-I      intronic chr9:19430780(+) A-I      intronic chr9:19430778(+) A-I      intronic chr9:19435629(+) A-I      intronic chr9:19435685(+) A-I      intronic chr9:19435732(+) A-I      intronic chr9:19438845(+) A-I      intronic chr9:19439378(+) A-I      intronic chr9:19439389(+) A-I      intronic chr9:19416783(+) A-I      intronic chr9:19412597(+) A-I      intronic chr9:19439425(+) A-I      intronic chr9:19439441(+) A-I      intronic chr9:19439495(+) A-I      intronic chr9:19439811(+) A-I      intronic chr9:19439850(+) A-I      intronic chr9:19439941(+) A-I      intronic chr9:19444274(+) A-I      intronic chr9:19416663(+) A-I      intronic chr9:19443820(+) A-I      intronic chr9:19444290(+) A-I      intronic chr9:19443855(+) A-I      intronic chr9:19439952(+) A-I      intronic chr9:19448079(+) A-I      intronic chr9:19439961(+) A-I      intronic chr9:19441173(+) A-I      intronic chr9:19448123(+) A-I      intronic chr9:19448132(+) A-I      intronic chr9:19449073(+) A-I      intronic chr9:19448288(+) A-I      intronic chr9:19441174(+) A-I      intronic chr9:19439844(+) A-I      intronic chr9:19441278(+) A-I      intronic chr9:19441283(+) A-I      intronic chr9:19442935(+) A-I      intronic chr9:19443710(+) A-I      intronic chr9:19448892(+) A-I      intronic chr9:19443741(+) A-I      intronic chr9:19443755(+) A-I      intronic chr9:19443857(+) A-I      intronic chr9:19439814(+) A-I      intronic chr9:19443794(+) A-I      intronic chr9:19439810(+) A-I      intronic chr9:19439808(+) A-I      intronic chr9:19439762(+) A-I      intronic chr9:19416740(+) A-I      intronic chr9:19416793(+) A-I      intronic chr9:19434607(+) A-I      intronic chr9:19419068(+) A-I      intronic chr9:19419085(+) A-I      intronic chr9:19416603(+) A-I      intronic chr9:19419109(+) A-I      intronic chr9:19426864(+) A-I      intronic chr9:19443800(+) A-I      intronic chr9:19449908(+) A-I      intronic chr9:19428224(+) A-I      intronic chr9:19428230(+) A-I      intronic chr9:19428259(+) A-I      intronic chr9:19439727(+) A-I      intronic chr9:19436042(+) A-I      intronic chr9:19448172(+) A-I      intronic chr9:19439431(+) A-I      intronic chr9:19439818(+) A-I      intronic chr9:19419700(+) A-I      intronic chr9:19410444(+) A-I      intronic chr9:19430841(+) A-I      intronic chr9:19416624(+) A-I      intronic chr9:19449007(+) A-I      intronic chr9:19415343(+) A-I      intronic chr9:19449907(+) A-I      intronic chr9:19448211(+) A-I      intronic chr9:19419114(+) A-I      intronic chr9:19439871(+) A-I      intronic chr9:19448910(+) A-I      intronic chr9:19449034(+) A-I      intronic chr9:19448884(+) A-I      intronic chr9:19410650(+) A-I      intronic chr9:19443724(+) A-I      intronic chr9:19430845(+) A-I      intronic chr9:19430785(+) A-I      intronic chr9:19435705(+) A-I      intronic chr9:19449080(+) A-I      intronic chr9:19423549(+) A-I      intronic chr9:19449078(+) A-I      intronic chr9:19418970(+) A-I      intronic chr9:19448292(+) A-I      intronic chr9:19439886(+) A-I      intronic chr9:19443784(+) A-I      intronic chr9:19439438(+) A-I      intronic chr9:19443349(+) A-I      intronic chr9:19439823(+) A-I      intronic chr9:19441085(+) A-I      intronic chr9:19439526(+) A-I      intronic chr9:19435630(+) A-I      intronic chr9:19439437(+) A-I      intronic chr9:19411457(+) A-I      intronic chr9:19430809(+) A-I      intronic chr9:19428836(+) A-I      intronic chr9:19442943(+) A-I      intronic chr9:19419650(+) A-I      intronic chr9:19416604(+) A-I      intronic chr9:19435831(+) A-I      intronic chr9:19428865(+) A-I      intronic chr9:19439953(+) A-I      intronic chr9:19429591(+) A-I      intronic chr9:19414539(+) A-I      intronic chr9:19411463(+) A-I      intronic chr9:19448194(+) A-I      intronic chr9:19438888(+) A-I      intronic chr9:19448225(+) A-I      intronic chr9:19438887(+) A-I      intronic chr9:19427726(+) A-I      intronic chr9:19430901(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACER2	chr9:19451067-19451068(+) m6A 3'UTR       24981863//22608085 chr9:19451210-19451211(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451241-19451242(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451257-19451258(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451273-19451274(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451278-19451279(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451337-19451338(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451342-19451343(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451347-19451348(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451356-19451357(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451367-19451368(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451473-19451474(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr9:19451504-19451505(+) m6A 3'UTR       24284625//24981863//22608085 chr9:19451519-19451520(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr9:19451667-19451668(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr9:19451679-19451680(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr9:19451695-19451696(+) m6A 3'UTR       24209618//24981863//22608085 chr9:19451768-19451769(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ACER2	Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ACER2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.