Detail Information

Basic Information:


  VIRBase ID:  

VHID00517661

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           HID1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p HID1
miRBase
Accession/Entrez ID		 MIMAT0001581 283987
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - 17orf28//C17orf28//DMC1//HID-1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR HID1
chr17:72965765(-) A-I      intronic
chr17:72963255(-) A-I      intronic
chr17:72953829(-) A-I      intronic
chr17:72966104(-) A-I      intronic
chr17:72965445(-) A-I      intronic
chr17:72963194(-) A-I      intronic
chr17:72965775(-) A-I      intronic
chr17:72965804(-) A-I      intronic
chr17:72964078(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HID1
chr17:72947387-72947388(-) m6A 3'UTR//exon       25456834//24981863//27773535//22608085
chr17:72947401-72947402(-) m6A 3'UTR//exon       25456834//24981863//27773535//22608085
chr17:72947422-72947423(-) m6A 3'UTR//exon       25456834//24981863//27773535//22608085
chr17:72947464-72947465(-) m6A 3'UTR//exon       25456834//24981863//27773535//22608085
chr17:72947497-72947498(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr17:72947506-72947507(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr17:72947521-72947522(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr17:72947556-72947557(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr17:72948421-72948422(-) m6A 3'UTR//CDS//exon       27773536
chr17:72949684-72949685(-) m6A 3'UTR//CDS//exon       27773536
chr17:72950253-72950254(-) m6A 3'UTR//CDS//exon       27773536
chr17:72950346-72950347(-) m6A 3'UTR//CDS//exon       27773536
chr17:72950387-72950388(-) m6A 3'UTR//CDS//exon       27773535//27773536
chr17:72951948-72951949(-) m6A 3'UTR//CDS//exon       27773535
chr17:72954761-72954762(-) m6A exon//intron       27773535
chr17:72954817-72954818(-) m6A 3'UTR//CDS//exon       27773535
chr17:72955088-72955089(-) m6A 3'UTR//CDS//exon       27773535
chr17:72956003-72956004(-) m6A 3'UTR//CDS//exon       27773535
chr17:72956015-72956016(-) m6A 3'UTR//CDS       27773535
chr17:72956237-72956238(-) m6A 3'UTR//CDS       27773535
chr17:72957707-72957708(-) m6A exon//intron       27773535
chr17:72957786-72957787(-) m6A exon//intron       27773535
chr17:72957846-72957847(-) m6A exon//intron       27773535
chr17:72960680-72960681(-) m6A CDS//exon//intron       27773536
chr17:72960695-72960696(-) m6A CDS//exon//intron       27773536
chr17:72963930-72963931(-) m6A exon//intron       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate HID1
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: HID1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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