Basic Information:

  VIRBase ID:  

VHID00517641

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PRTG:  NM_173814     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PRTG
miRBase Accession/Entrez ID	MIMAT0001581	283659
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	IGDCC5

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PRTG	chr15:55914935(-) A-I      intronic chr15:55914931(-) A-I      intronic chr15:56011146(-) A-I      intronic chr15:55914937(-) A-I      intronic chr15:56011136(-) A-I      intronic chr15:55915600(-) A-I      intronic chr15:55914938(-) A-I      intronic chr15:55915617(-) A-I      intronic chr15:56011185(-) A-I      intronic chr15:55914799(-) A-I      intronic chr15:55914794(-) A-I      intronic chr15:55914966(-) A-I      intronic chr15:55914746(-) A-I      intronic chr15:55914714(-) A-I      intronic chr15:55914667(-) A-I      intronic chr15:55914636(-) A-I      intronic chr15:55914553(-) A-I      intronic chr15:55914927(-) A-I      intronic chr15:55914548(-) A-I      intronic chr15:56024821(-) A-I      intronic chr15:56024463(-) A-I      intronic chr15:56023680(-) A-I      intronic chr15:55914531(-) A-I      intronic chr15:55914499(-) A-I      intronic chr15:55914491(-) A-I      intronic chr15:55914451(-) A-I      intronic chr15:56023706(-) A-I      intronic chr15:56023690(-) A-I      intronic chr15:55915006(-) A-I      intronic chr15:56022935(-) A-I      intronic chr15:56011142(-) A-I      intronic chr15:55963917(-) A-I      intronic chr15:55963059(-) A-I      intronic chr15:55962895(-) A-I      intronic chr15:56016244(-) A-I      intronic chr15:55939362(-) A-I      intronic chr15:55936122(-) A-I      intronic chr15:55935105(-) A-I      intronic chr15:55915717(-) A-I      intronic chr15:55915665(-) A-I      intronic chr15:55915643(-) A-I      intronic chr15:55915549(-) A-I      intronic chr15:55962987(-) A-I      intronic chr15:55915522(-) A-I      intronic chr15:55915521(-) A-I      intronic chr15:55958026(-) A-I      intronic chr15:55915015(-) A-I      intronic chr15:55914984(-) A-I      intronic chr15:55915653(-) A-I      intronic chr15:55914958(-) A-I      intronic chr15:55914916(-) A-I      intronic chr15:55914913(-) A-I      intronic chr15:55914912(-) A-I      intronic chr15:55914501(-) A-I      intronic chr15:55914910(-) A-I      intronic chr15:55914898(-) A-I      intronic chr15:55914840(-) A-I      intronic chr15:55956477(-) A-I      intronic chr15:55918395(-) A-I      intronic chr15:55915720(-) A-I      intronic chr15:55914928(-) A-I      intronic chr15:55956941(-) A-I      intronic chr15:55915764(-) A-I      intronic chr15:56016226(-) A-I      intronic chr15:55914720(-) A-I      intronic chr15:55914554(-) A-I      intronic chr15:55950642(-) A-I      intronic chr15:55934571(-) A-I      intronic chr15:55915763(-) A-I      intronic chr15:55950769(-) A-I      intronic chr15:55956949(-) A-I      intronic chr15:55914710(-) A-I      intronic chr15:55935103(-) A-I      intronic chr15:56001281(-) A-I      intronic chr15:55914733(-) A-I      intronic chr15:56016230(-) A-I      intronic chr15:55927000(-) A-I      intronic chr15:55938329(-) A-I      intronic chr15:55963931(-) A-I      intronic chr15:55998881(-) A-I      intronic chr15:55990567(-) A-I      intronic chr15:55914544(-) A-I      intronic chr15:55950680(-) A-I      intronic chr15:56025989(-) A-I      intronic chr15:55914508(-) A-I      intronic chr15:56011160(-) A-I      intronic chr15:55914862(-) A-I      intronic chr15:55915007(-) A-I      intronic chr15:55918581(-) A-I      intronic chr15:56012146(-) A-I      intronic chr15:55941843(-) A-I      intronic chr15:55915574(-) A-I      intronic chr15:55950711(-) A-I      intronic chr15:56025252(-) A-I      intronic chr15:55998945(-) A-I      intronic chr15:55917774(-) A-I      intronic chr15:55983797(-) A-I      intronic chr15:55915509(-) A-I      intronic chr15:55913732(-) A-I      intronic chr15:56025942(-) A-I      intronic chr15:55963800(-) A-I      intronic chr15:55950704(-) A-I      intronic chr15:55910241(-) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PRTG	chr15:55903803-55903804(-) m6A 3'UTR       27773535 chr15:55903958-55903959(-) m6A 3'UTR       27773535 chr15:55904082-55904083(-) m6A 3'UTR       27773535 chr15:55904094-55904095(-) m6A 3'UTR       27773535 chr15:55905044-55905045(-) m6A 3'UTR       24981863 chr15:55905089-55905090(-) m6A 3'UTR       24981863 chr15:55912000-55912001(-) m6A 3'UTR       24981863//22608085 chr15:55912007-55912008(-) m6A 3'UTR       24981863//22608085 chr15:55912014-55912015(-) m6A 3'UTR       24981863//22608085 chr15:55912126-55912127(-) m6A 3'UTR       27773535//22608085 chr15:55912155-55912156(-) m6A 3'UTR       24284625//27773535//22608085 chr15:55912295-55912296(-) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr15:55912326-55912327(-) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr15:55912353-55912354(-) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr15:55912370-55912371(-) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr15:55912393-55912394(-) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr15:55948269-55948270(-) m6A 3'UTR//intron       27773535 chr15:55948339-55948340(-) m6A 3'UTR//intron       27773535 chr15:55948363-55948364(-) m6A 3'UTR//intron       27773535 chr15:55948373-55948374(-) m6A 3'UTR//intron       27773535 chr15:55948428-55948429(-) m6A 3'UTR//intron       27773535 chr15:55948444-55948445(-) m6A 3'UTR//intron       27773535 chr15:55948462-55948463(-) m6A 3'UTR//intron       27773535 chr15:56035175-56035176(-) m6A 5'UTR       25456834//24981863//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PRTG	Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PRTG

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.