Basic Information:

  VIRBase ID:  

VHID00517632

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SLC46A3:  NM_001347960     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SLC46A3
miRBase Accession/Entrez ID	MIMAT0001581	283537
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	FKSG16

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC46A3	chr13:29282835(-) A-I      intronic chr13:29277766(-) A-I      intronic chr13:29282825(-) A-I      intronic chr13:29282848(-) A-I      intronic chr13:29282877(-) A-I      intronic chr13:29282887(-) A-I      intronic chr13:29282893(-) A-I      intronic chr13:29282462(-) A-I      intronic chr13:29282532(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC46A3	chr13:29288647(-) C-T intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC46A3	chr13:29274265-29274266(-) m6A 3'UTR//exon       27773535 chr13:29274422-29274423(-) m6A 3'UTR//exon       27773535 chr13:29274442-29274443(-) m6A 3'UTR//exon       27773535 chr13:29274516-29274517(-) m6A 3'UTR//exon       27773535 chr13:29275488-29275489(-) m6A 3'UTR//exon//intron       24981863//27773535//22608085 chr13:29275500-29275501(-) m6A 3'UTR//exon//intron       24981863//27773535//22608085 chr13:29275505-29275506(-) m6A 3'UTR//exon//intron       24981863//27773535//22608085 chr13:29275532-29275533(-) m6A 3'UTR//exon//intron       24981863//27773535//22608085 chr13:29275569-29275570(-) m6A 3'UTR//exon//intron       24981863//27773535//22608085 chr13:29275621-29275622(-) m6A 3'UTR//exon//intron       24981863//22608085 chr13:29275640-29275641(-) m6A CDS//exon       24981863//22608085 chr13:29275678-29275679(-) m6A CDS//exon       24981863 chr13:29287324-29287325(-) m6A CDS       24981863//22608085 chr13:29287333-29287334(-) m6A CDS       24981863//22608085 chr13:29287345-29287346(-) m6A CDS       24981863//22608085 chr13:29287380-29287381(-) m6A CDS       24981863//22608085 chr13:29287387-29287388(-) m6A CDS       24981863//22608085 chr13:29287393-29287394(-) m6A CDS       24981863//22608085 chr13:29292854-29292855(-) m6A 5'UTR       24981863 chr13:29292920-29292921(-) m6A 5'UTR       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SLC46A3	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SLC46A3

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.