Basic Information:

  VIRBase ID:  

VHID00517611

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          OLFML1:  NM_198474     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	OLFML1
miRBase Accession/Entrez ID	MIMAT0001581	283298
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	MVAL564//UNQ564

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OLFML1	chr11:7532009(+) A-I      3'UTR chr11:7531969(+) A-I      3'UTR chr11:7531995(+) A-I      3'UTR chr11:7532027(+) A-I      3'UTR chr11:7531955(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	OLFML1	chr11:7526444(+) A-I intron -    22327324 chr11:7527031(+) A-I intron -    22327324 chr11:7526297(+) T-C intron -    22484847 chr11:7526319(+) T-C intron -    22484847 chr11:7526444(+) T-C intron -    22484847 chr11:7526859(+) T-C intron -    22484847 chr11:7526940(+) T-C intron -    22484847 chr11:7527031(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OLFML1	chr11:7506844-7506845(+) m6A 5'UTR//exon       24284625 chr11:7506889-7506890(+) m6A 5'UTR//exon//intron       24284625 chr11:7506909-7506910(+) m6A 5'UTR//exon//intron       24284625 chr11:7506929-7506930(+) m6A 5'UTR//exon//intron       24284625 chr11:7506963-7506964(+) m6A 5'UTR//exon//intron       24284625 chr11:7507051-7507052(+) m6A 5'UTR//exon//intron       24284625 chr11:7507081-7507082(+) m6A 5'UTR//exon//intron       24284625 chr11:7509574-7509575(+) m6A CDS//exon//intron       24284625 chr11:7509579-7509580(+) m6A CDS//exon//intron       24284625 chr11:7509630-7509631(+) m6A CDS//exon//intron       24284625 chr11:7509654-7509655(+) m6A exon//intron       24284625 chr11:7509682-7509683(+) m6A exon//intron       24284625 chr11:7509698-7509699(+) m6A exon//intron       24284625 chr11:7509706-7509707(+) m6A exon//intron       24284625 chr11:7530685-7530686(+) m6A 3'UTR//CDS       24284625 chr11:7530757-7530758(+) m6A 3'UTR//CDS       24284625 chr11:7530781-7530782(+) m6A 3'UTR//CDS       24284625 chr11:7530855-7530856(+) m6A 3'UTR//CDS       24284625 chr11:7530942-7530943(+) m6A 3'UTR//CDS       24284625 chr11:7531273-7531274(+) m6A 3'UTR//CDS       24284625 chr11:7531301-7531302(+) m6A 3'UTR//CDS       24284625 chr11:7531369-7531370(+) m6A 3'UTR//CDS       24284625 chr11:7531385-7531386(+) m6A 3'UTR//CDS       24284625 chr11:7531392-7531393(+) m6A 3'UTR//CDS       24284625 chr11:7531471-7531472(+) m6A 3'UTR       24284625 chr11:7531650-7531651(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	OLFML1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: OLFML1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.