Basic Information:

  VIRBase ID:  

VHID00517604

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CCDC88B:  NM_032251     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CCDC88B
miRBase Accession/Entrez ID	MIMAT0001581	283234
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	BRLZ//CCDC88//gipie//HKRP3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCDC88B	chr11:64114006(+) A-I      intronic chr11:64113303(+) A-I      intronic chr11:64113405(+) A-I      intronic chr11:64113398(+) A-I      intronic chr11:64114119(+) A-I      intronic chr11:64120592(+) A-I      Syn:Leu->Leu chr11:64115363(+) A-I      intronic chr11:64113323(+) A-I      intronic chr11:64115361(+) A-I      intronic chr11:64114406(+) A-I      intronic chr11:64114396(+) A-I      intronic chr11:64113440(+) A-I      intronic chr11:64113217(+) A-I      intronic chr11:64113328(+) A-I      intronic chr11:64113332(+) A-I      intronic chr11:64113327(+) A-I      intronic chr11:64115344(+) A-I      intronic chr11:64113366(+) A-I      intronic chr11:64118243(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCDC88B	chr11:64120592(+) A-I exon CDS    15342557 chr11:64122883(+) A-I intron -    15342557 chr11:64123536(+) A-I intron -    15342557 chr11:64123558(+) A-I intron -    15342557 chr11:64123582(+) A-I intron -    15342557 chr11:64123586(+) A-I intron -    15342557 chr11:64123596(+) A-I intron -    15342557 chr11:64123598(+) A-I intron -    15342557 chr11:64123623(+) A-I intron -    15342557 chr11:64123651(+) A-I intron -    15342557 chr11:64123680(+) A-I intron -    15342557 chr11:64123692(+) A-I intron -    15342557 chr11:64123705(+) A-I intron -    15342557 chr11:64123811(+) A-I intron -    15342557 chr11:64123816(+) A-I intron -    15342557 chr11:64123820(+) A-I intron -    15342557 chr11:64123825(+) A-I intron -    15342557 chr11:64123838(+) A-I intron -    15342557 chr11:64123842(+) A-I intron -    15342557 chr11:64123849(+) A-I intron -    15342557 chr11:64123854(+) A-I intron -    15342557 chr11:64123859(+) A-I intron -    15342557 chr11:64123860(+) A-I intron -    15342557 chr11:64123861(+) A-I intron -    15342557 chr11:64123889(+) A-I intron -    15342557 chr11:64123898(+) A-I intron -    15342557 chr11:64123906(+) A-I intron -    15342557 chr11:64123924(+) A-I intron -    15342557 chr11:64123925(+) A-I intron -    15342557 chr11:64123934(+) A-I intron -    15342557 chr11:64123938(+) A-I intron -    15342557 chr11:64123951(+) A-I intron -    15342557 chr11:64123957(+) A-I intron -    15342557 chr11:64123977(+) A-I intron -    15342557 chr11:64113327(+) A-G intron -    22484847 chr11:64113332(+) A-G intron -    22484847 chr11:64113366(+) A-G intron -    22484847 chr11:64123898(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCDC88B	chr11:64107769-64107770(+) m6A CDS//exon       - chr11:64108086-64108087(+) m6A CDS//exon       - chr11:64108115-64108116(+) m6A CDS//exon       - chr11:64109791-64109792(+) m6A CDS//exon       - chr11:64110010-64110011(+) m6A CDS//exon       - chr11:64111006-64111007(+) m6A CDS//exon       - chr11:64111317-64111318(+) m6A CDS//exon       - chr11:64111333-64111334(+) m6A CDS//exon       - chr11:64111496-64111497(+) m6A CDS//exon       - chr11:64111531-64111532(+) m6A CDS//exon       25456834 chr11:64111604-64111605(+) m6A CDS//exon       25456834 chr11:64111625-64111626(+) m6A CDS//exon       25456834//24981863 chr11:64111673-64111674(+) m6A CDS//exon       25456834 chr11:64111715-64111716(+) m6A CDS//exon       25456834 chr11:64111730-64111731(+) m6A CDS//exon       25456834 chr11:64111765-64111766(+) m6A CDS//exon       25456834 chr11:64111846-64111847(+) m6A CDS//exon       25456834 chr11:64111882-64111883(+) m6A CDS//exon       25456834//24981863 chr11:64111938-64111939(+) m6A CDS//exon       25456834//24981863//27371828//22608085 chr11:64112012-64112013(+) m6A CDS//exon       25456834//24981863//27371828//22608085 chr11:64112024-64112025(+) m6A CDS//exon       25456834//24981863//27371828//22608085 chr11:64112037-64112038(+) m6A CDS//exon       25456834//24981863//27371828//22608085 chr11:64112087-64112088(+) m6A CDS//exon       25456834//24981863//27371828//22608085 chr11:64112103-64112104(+) m6A CDS//exon       25456834//24981863//27371828//22608085 chr11:64112288-64112289(+) m6A CDS//exon       27371828 chr11:64116507-64116508(+) m6A CDS//intron       - chr11:64116842-64116843(+) m6A CDS//exon       - chr11:64117104-64117105(+) m6A CDS//exon       - chr11:64117358-64117359(+) m6A exon//intron       25456834 chr11:64117363-64117364(+) m6A exon//intron       25456834 chr11:64117549-64117550(+) m6A exon//intron       - chr11:64117572-64117573(+) m6A exon//intron       - chr11:64118163-64118164(+) m6A exon//intron       - chr11:64118691-64118692(+) m6A CDS//exon       - chr11:64118794-64118795(+) m6A exon//intron       - chr11:64119700-64119701(+) m6A CDS//exon       24284625//27371828 chr11:64119731-64119732(+) m6A CDS//exon       24284625//27371828 chr11:64119783-64119784(+) m6A CDS//exon       24284625//27371828 chr11:64119803-64119804(+) m6A CDS//exon       - chr11:64120478-64120479(+) m6A exon//intron       - chr11:64120485-64120486(+) m6A exon//intron       - chr11:64120677-64120678(+) m6A CDS//exon       - chr11:64120766-64120767(+) m6A exon//intron       - chr11:64120859-64120860(+) m6A CDS//exon       - chr11:64120901-64120902(+) m6A CDS//exon       - chr11:64120937-64120938(+) m6A CDS//exon       - chr11:64120953-64120954(+) m6A CDS//exon       24284625 chr11:64121188-64121189(+) m6A 5'UTR//CDS//exon       24284625 chr11:64121242-64121243(+) m6A CDS//exon       24284625 chr11:64121280-64121281(+) m6A CDS//exon       - chr11:64121495-64121496(+) m6A CDS//exon//intron       - chr11:64121638-64121639(+) m6A CDS//exon//intron       - chr11:64122724-64122725(+) m6A CDS//exon       24981863 chr11:64122750-64122751(+) m6A CDS//exon       24981863 chr11:64122803-64122804(+) m6A CDS//exon       24981863 chr11:64122879-64122880(+) m6A exon//intron       24284625//24981863 chr11:64122920-64122921(+) m6A exon//intron       24981863 chr11:64123032-64123033(+) m6A CDS//exon       - chr11:64123052-64123053(+) m6A CDS//exon       - chr11:64123063-64123064(+) m6A CDS//exon       - chr11:64123074-64123075(+) m6A CDS//exon       - chr11:64123081-64123082(+) m6A CDS//exon       - chr11:64123111-64123112(+) m6A exon//intron       - chr11:64123159-64123160(+) m6A exon//intron       - chr11:64124457-64124458(+) m6A exon//intron       - chr11:64124526-64124527(+) m6A CDS//exon       - chr11:64124576-64124577(+) m6A 3'UTR//CDS//exon       - chr11:64124659-64124660(+) m6A 3'UTR//CDS//exon       24284625 chr11:64124679-64124680(+) m6A 3'UTR//CDS//exon       24284625 chr11:64124754-64124755(+) m6A 3'UTR//CDS//exon       24284625//25456834 chr11:64124884-64124885(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863 chr11:64124930-64124931(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863 chr11:64124964-64124965(+) m6A 3'UTR//exon       24284625//25456834//24981863 chr11:64124991-64124992(+) m6A 3'UTR//exon       24284625//25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CCDC88B	Exosome Blood     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CCDC88B

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.