Basic Information:

  VIRBase ID:  

VHID00517451

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          MCOLN2:  NM_001330647     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	MCOLN2
miRBase Accession/Entrez ID	MIMAT0001581	255231
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	TRP-ML2//TRPML2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MCOLN2	chr1:85397480(-) A-I      intronic chr1:85411625(-) A-I      intronic chr1:85417762(-) A-I      intronic chr1:85411519(-) A-I      intronic chr1:85407093(-) A-I      intronic chr1:85406986(-) A-I      intronic chr1:85406974(-) A-I      intronic chr1:85398089(-) A-I      intronic chr1:85398084(-) A-I      intronic chr1:85398076(-) A-I      intronic chr1:85398066(-) A-I      intronic chr1:85397992(-) A-I      intronic chr1:85397980(-) A-I      intronic chr1:85453999(-) A-I      intronic chr1:85450629(-) A-I      intronic chr1:85450466(-) A-I      intronic chr1:85450460(-) A-I      intronic chr1:85449471(-) A-I      intronic chr1:85397505(-) A-I      intronic chr1:85449436(-) A-I      intronic chr1:85431818(-) A-I      intronic chr1:85431717(-) A-I      intronic chr1:85417694(-) A-I      intronic chr1:85417677(-) A-I      intronic chr1:85417661(-) A-I      intronic chr1:85411696(-) A-I      intronic chr1:85411602(-) A-I      intronic chr1:85449127(-) A-I      intronic chr1:85411601(-) A-I      intronic chr1:85411588(-) A-I      intronic chr1:85411551(-) A-I      intronic chr1:85411536(-) A-I      intronic chr1:85411521(-) A-I      intronic chr1:85438925(-) A-I      intronic chr1:85417687(-) A-I      intronic chr1:85449497(-) A-I      intronic chr1:85398075(-) A-I      intronic chr1:85398032(-) A-I      intronic chr1:85456561(-) A-I      intronic chr1:85407080(-) A-I      intronic chr1:85411541(-) A-I      intronic chr1:85438903(-) A-I      intronic chr1:85450591(-) A-I      intronic chr1:85391753(-) A-I      3'UTR chr1:85450569(-) A-I      intronic chr1:85391848(-) A-I      3'UTR chr1:85448514(-) A-I      intronic chr1:85450495(-) A-I      intronic chr1:85450486(-) A-I      intronic chr1:85411711(-) A-I      intronic chr1:85411633(-) A-I      intronic chr1:85456357(-) A-I      intronic chr1:85410031(-) A-I      intronic chr1:85398063(-) A-I      intronic chr1:85449072(-) A-I      intronic chr1:85455795(-) A-I      intronic chr1:85456344(-) A-I      intronic chr1:85406935(-) A-I      intronic chr1:85397579(-) A-I      intronic chr1:85397464(-) A-I      intronic chr1:85411669(-) A-I      intronic chr1:85398146(-) A-I      intronic chr1:85410097(-) A-I      intronic chr1:85397492(-) A-I      intronic chr1:85449092(-) A-I      intronic chr1:85398000(-) A-I      intronic chr1:85410209(-) A-I      intronic chr1:85397701(-) A-I      intronic chr1:85417718(-) A-I      intronic chr1:85417630(-) A-I      intronic chr1:85450550(-) A-I      intronic chr1:85408112(-) A-I      intronic chr1:85397552(-) A-I      intronic chr1:85406921(-) A-I      intronic chr1:85411568(-) A-I      intronic chr1:85410177(-) A-I      intronic chr1:85395846(-) A-I      intronic chr1:85397504(-) A-I      intronic chr1:85411610(-) A-I      intronic chr1:85439155(-) A-I      intronic chr1:85411659(-) A-I      intronic chr1:85411600(-) A-I      intronic chr1:85456398(-) A-I      intronic chr1:85449498(-) A-I      intronic chr1:85450566(-) A-I      intronic chr1:85398177(-) A-I      intronic chr1:85397487(-) A-I      intronic chr1:85411596(-) A-I      intronic chr1:85450428(-) A-I      intronic chr1:85407058(-) A-I      intronic chr1:85449630(-) A-I      intronic chr1:85407021(-) A-I      intronic chr1:85417483(-) A-I      intronic chr1:85407068(-) A-I      intronic chr1:85398073(-) A-I      intronic chr1:85417551(-) A-I      intronic chr1:85449028(-) A-I      intronic chr1:85397465(-) A-I      intronic chr1:85398059(-) A-I      intronic chr1:85454008(-) A-I      intronic chr1:85397565(-) A-I      intronic chr1:85450578(-) A-I      intronic chr1:85391553(-) A-I      3'UTR chr1:85455815(-) A-I      intronic chr1:85411611(-) A-I      intronic chr1:85449587(-) A-I      intronic chr1:85417686(-) A-I      intronic chr1:85397563(-) A-I      intronic chr1:85407098(-) A-I      intronic chr1:85411650(-) A-I      intronic chr1:85438975(-) A-I      intronic chr1:85417769(-) A-I      intronic chr1:85448604(-) A-I      intronic chr1:85411651(-) A-I      intronic chr1:85447994(-) A-I      intronic chr1:85411635(-) A-I      intronic chr1:85411492(-) A-I      intronic chr1:85407154(-) A-I      intronic chr1:85411609(-) A-I      intronic chr1:85450643(-) A-I      intronic chr1:85417707(-) A-I      intronic chr1:85398163(-) A-I      intronic chr1:85407178(-) A-I      intronic chr1:85450514(-) A-I      intronic chr1:85448070(-) A-I      intronic chr1:85391573(-) A-I      3'UTR chr1:85455723(-) A-I      intronic chr1:85407136(-) A-I      intronic chr1:85411605(-) A-I      intronic chr1:85398033(-) A-I      intronic chr1:85450583(-) A-I      intronic chr1:85411614(-) A-I      intronic chr1:85449248(-) A-I      intronic chr1:85410133(-) A-I      intronic chr1:85450475(-) A-I      intronic chr1:85449064(-) A-I      intronic chr1:85449553(-) A-I      intronic chr1:85397650(-) A-I      intronic chr1:85449224(-) A-I      intronic chr1:85397561(-) A-I      intronic chr1:85398168(-) A-I      intronic chr1:85398074(-) A-I      intronic chr1:85397624(-) A-I      intronic chr1:85397705(-) A-I      intronic chr1:85410134(-) A-I      intronic chr1:85398123(-) A-I      intronic chr1:85410130(-) A-I      intronic chr1:85397585(-) A-I      intronic chr1:85397543(-) A-I      intronic chr1:85417493(-) A-I      intronic chr1:85411608(-) A-I      intronic chr1:85398065(-) A-I      intronic chr1:85410153(-) A-I      intronic chr1:85391578(-) A-I      3'UTR chr1:85397639(-) A-I      intronic chr1:85397517(-) A-I      intronic chr1:85397491(-) A-I      intronic chr1:85448093(-) A-I      intronic chr1:85398152(-) A-I      intronic chr1:85405757(-) A-I      intronic chr1:85407174(-) A-I      intronic chr1:85449045(-) A-I      intronic chr1:85397622(-) A-I      intronic chr1:85397607(-) A-I      intronic chr1:85417593(-) A-I      intronic chr1:85398078(-) A-I      intronic chr1:85398128(-) A-I      intronic chr1:85410059(-) A-I      intronic chr1:85407142(-) A-I      intronic chr1:85397583(-) A-I      intronic chr1:85407117(-) A-I      intronic chr1:85449592(-) A-I      intronic chr1:85397560(-) A-I      intronic chr1:85449488(-) A-I      intronic chr1:85397479(-) A-I      intronic chr1:85417658(-) A-I      intronic chr1:85398068(-) A-I      intronic chr1:85398064(-) A-I      intronic chr1:85398133(-) A-I      intronic chr1:85449561(-) A-I      intronic chr1:85398062(-) A-I      intronic chr1:85417584(-) A-I      intronic chr1:85391752(-) A-I      3'UTR chr1:85393502(-) A-I      intronic chr1:85398039(-) A-I      intronic chr1:85411501(-) A-I      intronic chr1:85448497(-) A-I      intronic chr1:85450570(-) A-I      intronic chr1:85397629(-) A-I      intronic chr1:85453954(-) A-I      intronic chr1:85397984(-) A-I      intronic chr1:85448071(-) A-I      intronic chr1:85453934(-) A-I      intronic chr1:85397506(-) A-I      intronic chr1:85407133(-) A-I      intronic chr1:85412419(-) A-I      intronic chr1:85410129(-) A-I      intronic chr1:85410036(-) A-I      intronic chr1:85449629(-) A-I      intronic chr1:85411567(-) A-I      intronic chr1:85449427(-) A-I      intronic chr1:85448524(-) A-I      intronic chr1:85395749(-) A-I      intronic chr1:85456366(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MCOLN2	chr1:85391553(-) A-I exon 3'UTR    15258596 chr1:85391573(-) A-I exon 3'UTR    15258596 chr1:85391578(-) A-I exon 3'UTR    15258596 chr1:85391752(-) A-I exon 3'UTR    15258596 chr1:85391753(-) A-I exon 3'UTR    15258596 chr1:85391848(-) A-I exon 3'UTR    15258596   //16100382 chr1:85397464(-) A-I intron -    22327324 chr1:85397465(-) A-I intron -    22327324 chr1:85397491(-) A-I intron -    22327324 chr1:85397492(-) A-I intron -    22327324 chr1:85397506(-) A-I intron -    22327324 chr1:85397560(-) A-I intron -    22327324 chr1:85397561(-) A-I intron -    22327324 chr1:85397565(-) A-I intron -    22327324 chr1:85397701(-) A-I intron -    22327324 chr1:85398000(-) A-I intron -    22327324 chr1:85398062(-) A-I intron -    22327324 chr1:85398063(-) A-I intron -    22327324 chr1:85398065(-) A-I intron -    22327324 chr1:85398068(-) A-I intron -    22327324 chr1:85398070(-) A-I intron -    22327324 chr1:85398078(-) A-I intron -    22327324 chr1:85398168(-) A-I intron -    22327324 chr1:85407178(-) A-I intron -    22327324 chr1:85449427(-) A-I intron -    22327324 chr1:85449497(-) A-I intron -    22327324 chr1:85449553(-) A-I intron -    22327324 chr1:85447994(-) A-G intron -    22484847 chr1:85391748(-) G-A exon 3'UTR    22484847 chr1:85391753(-) A-T exon 3'UTR    22484847 chr1:85395735(-) G-C intron -    22484847 chr1:85395749(-) A-G intron -    22484847 chr1:85395846(-) A-G intron -    22484847 chr1:85397464(-) A-G intron -    22484847 chr1:85397465(-) A-G intron -    22484847 chr1:85397479(-) A-G intron -    22484847 chr1:85397487(-) A-G intron -    22484847 chr1:85397491(-) A-G intron -    22484847 chr1:85397492(-) A-G intron -    22484847 chr1:85397517(-) A-G intron -    22484847 chr1:85397543(-) A-G intron -    22484847 chr1:85397560(-) A-G intron -    22484847 chr1:85397561(-) A-G intron -    22484847 chr1:85397565(-) A-G intron -    22484847 chr1:85397583(-) A-G intron -    22484847 chr1:85397585(-) A-G intron -    22484847 chr1:85397607(-) A-G intron -    22484847 chr1:85397622(-) A-G intron -    22484847 chr1:85397624(-) A-G intron -    22484847 chr1:85397650(-) A-G intron -    22484847 chr1:85397701(-) A-G intron -    22484847 chr1:85397984(-) A-G intron -    22484847 chr1:85397989(-) A-C intron -    22484847 chr1:85398000(-) A-G intron -    22484847 chr1:85398032(-) A-G intron -    22484847 chr1:85398033(-) A-G intron -    22484847 chr1:85398059(-) A-G intron -    22484847 chr1:85398062(-) A-G intron -    22484847 chr1:85398063(-) A-G intron -    22484847 chr1:85398064(-) A-G intron -    22484847 chr1:85398065(-) A-G intron -    22484847 chr1:85398068(-) A-G intron -    22484847 chr1:85398073(-) A-G intron -    22484847 chr1:85398074(-) A-G intron -    22484847 chr1:85398075(-) A-G intron -    22484847 chr1:85398078(-) A-G intron -    22484847 chr1:85398123(-) A-G intron -    22484847 chr1:85398128(-) A-G intron -    22484847 chr1:85398133(-) A-G intron -    22484847 chr1:85398152(-) A-G intron -    22484847 chr1:85398163(-) A-G intron -    22484847 chr1:85398168(-) A-G intron -    22484847 chr1:85398177(-) A-G intron -    22484847 chr1:85406935(-) A-G intron -    22484847 chr1:85407021(-) A-G intron -    22484847 chr1:85407080(-) A-G intron -    22484847 chr1:85407098(-) A-G intron -    22484847 chr1:85407117(-) A-G intron -    22484847 chr1:85407133(-) A-G intron -    22484847 chr1:85407142(-) A-G intron -    22484847 chr1:85407154(-) A-G intron -    22484847 chr1:85407174(-) A-G intron -    22484847 chr1:85407178(-) A-G intron -    22484847 chr1:85410031(-) A-G intron -    22484847 chr1:85410059(-) A-G intron -    22484847 chr1:85410097(-) A-G intron -    22484847 chr1:85410129(-) A-G intron -    22484847 chr1:85410130(-) A-G intron -    22484847 chr1:85410133(-) A-G intron -    22484847 chr1:85410177(-) A-G intron -    22484847 chr1:85410209(-) A-G intron -    22484847 chr1:85411492(-) A-G intron -    22484847 chr1:85411501(-) A-G intron -    22484847 chr1:85411541(-) A-G intron -    22484847 chr1:85411567(-) A-G intron -    22484847 chr1:85411568(-) A-G intron -    22484847 chr1:85411592(-) G-A intron -    22484847 chr1:85411600(-) A-G intron -    22484847 chr1:85411608(-) A-G intron -    22484847 chr1:85411609(-) A-G intron -    22484847 chr1:85411611(-) A-G intron -    22484847 chr1:85411614(-) A-G intron -    22484847 chr1:85411635(-) A-G intron -    22484847 chr1:85411650(-) A-G intron -    22484847 chr1:85411651(-) A-G intron -    22484847 chr1:85411659(-) A-G intron -    22484847 chr1:85411711(-) A-G intron -    22484847 chr1:85417630(-) A-G intron -    22484847 chr1:85417686(-) A-G intron -    22484847 chr1:85417687(-) A-G intron -    22484847 chr1:85417707(-) A-G intron -    22484847 chr1:85417718(-) A-G intron -    22484847 chr1:85419235(-) T-G intron -    22484847 chr1:85435253(-) G-T intron -    22484847 chr1:85436215(-) A-T intron -    22484847 chr1:85437709(-) C-G intron -    22484847 chr1:85438925(-) A-G intron -    22484847 chr1:85438975(-) A-G intron -    22484847 chr1:85442278(-) C-T intron -    22484847 chr1:85448093(-) A-G intron -    22484847 chr1:85448604(-) A-G intron -    22484847 chr1:85449028(-) A-G intron -    22484847 chr1:85449045(-) A-G intron -    22484847 chr1:85449064(-) A-G intron -    22484847 chr1:85449072(-) A-G intron -    22484847 chr1:85449092(-) A-G intron -    22484847 chr1:85449427(-) A-G intron -    22484847 chr1:85449488(-) A-G intron -    22484847 chr1:85449497(-) A-G intron -    22484847 chr1:85449498(-) A-G intron -    22484847 chr1:85449553(-) A-G intron -    22484847 chr1:85449561(-) A-G intron -    22484847 chr1:85449587(-) A-G intron -    22484847 chr1:85449629(-) A-G intron -    22484847 chr1:85450428(-) A-G intron -    22484847 chr1:85450475(-) A-G intron -    22484847 chr1:85450486(-) A-G intron -    22484847 chr1:85450495(-) A-G intron -    22484847 chr1:85450514(-) A-G intron -    22484847 chr1:85450550(-) A-G intron -    22484847 chr1:85450566(-) A-G intron -    22484847 chr1:85450569(-) A-G intron -    22484847 chr1:85450570(-) A-G intron -    22484847 chr1:85450578(-) A-G intron -    22484847 chr1:85450583(-) A-G intron -    22484847 chr1:85450591(-) A-G intron -    22484847 chr1:85450643(-) A-G intron -    22484847 chr1:85452191(-) C-T intron -    22484847 chr1:85453934(-) A-G intron -    22484847 chr1:85453954(-) A-G intron -    22484847 chr1:85454008(-) A-G intron -    22484847 chr1:85455815(-) A-G intron -    22484847 chr1:85456344(-) A-G intron -    22484847 chr1:85456366(-) A-G intron -    22484847 chr1:85459608(-) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MCOLN2	chr1:85391347-85391348(-) m6A 3'UTR       28052920 chr1:85391532-85391533(-) m6A 3'UTR       24284625//28052920//22608085 chr1:85391552-85391553(-) m6A 3'UTR       24284625//28052920//22608085 chr1:85392169-85392170(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085 chr1:85392189-85392190(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085 chr1:85392242-85392243(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//22608085 chr1:85392293-85392294(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//22608085 chr1:85392309-85392310(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//22608085 chr1:85462676-85462677(-) m6A 5'UTR//exon//intron       27773536 chr1:85462766-85462767(-) m6A 5'UTR//exon       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MCOLN2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: MCOLN2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.