Detail Information

Basic Information:


  VIRBase ID:  

VHID00517409

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           BRWD3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p BRWD3
miRBase
Accession/Entrez ID		 MIMAT0001581 254065
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - BRODL//MRX93

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BRWD3
chrX:80051727(-) A-I      intronic
chrX:80003650(-) A-I      intronic
chrX:80006207(-) A-I      intronic
chrX:80051892(-) A-I      intronic
chrX:80051900(-) A-I      intronic
chrX:80058360(-) A-I      intronic
chrX:80045147(-) A-I      intronic
chrX:80051722(-) A-I      intronic
chrX:80051416(-) A-I      intronic
chrX:80049421(-) A-I      intronic
chrX:80045687(-) A-I      intronic
chrX:80045486(-) A-I      intronic
chrX:80007676(-) A-I      intronic
chrX:80045139(-) A-I      intronic
chrX:80045104(-) A-I      intronic
chrX:80045090(-) A-I      intronic
chrX:80045071(-) A-I      intronic
chrX:80045042(-) A-I      intronic
chrX:80045023(-) A-I      intronic
chrX:80045013(-) A-I      intronic
chrX:80042290(-) A-I      intronic
chrX:80042282(-) A-I      intronic
chrX:80042276(-) A-I      intronic
chrX:80042193(-) A-I      intronic
chrX:80041447(-) A-I      intronic
chrX:80041420(-) A-I      intronic
chrX:80041405(-) A-I      intronic
chrX:80041361(-) A-I      intronic
chrX:80038278(-) A-I      intronic
chrX:80038210(-) A-I      intronic
chrX:80035017(-) A-I      intronic
chrX:80034596(-) A-I      intronic
chrX:80033374(-) A-I      intronic
chrX:80033056(-) A-I      intronic
chrX:80033016(-) A-I      intronic
chrX:80016501(-) A-I      intronic
chrX:80010460(-) A-I      intronic
chrX:80010375(-) A-I      intronic
chrX:80010358(-) A-I      intronic
chrX:80010326(-) A-I      intronic
chrX:80010303(-) A-I      intronic
chrX:80010271(-) A-I      intronic
chrX:80008946(-) A-I      intronic
chrX:80052462(-) A-I      intronic
chrX:80051809(-) A-I      intronic
chrX:80051732(-) A-I      intronic
chrX:80008907(-) A-I      intronic
chrX:80008906(-) A-I      intronic
chrX:80008829(-) A-I      intronic
chrX:80008301(-) A-I      intronic
chrX:80007729(-) A-I      intronic
chrX:80007712(-) A-I      intronic
chrX:80045654(-) A-I      intronic
chrX:80042207(-) A-I      intronic
chrX:80033422(-) A-I      intronic
chrX:80033080(-) A-I      intronic
chrX:80008302(-) A-I      intronic
chrX:79969823(-) A-I      intronic
chrX:80016544(-) A-I      intronic
chrX:80057326(-) A-I      intronic
chrX:80057094(-) A-I      intronic
chrX:80007681(-) A-I      intronic
chrX:79991050(-) A-I      intronic
chrX:80035065(-) A-I      intronic
chrX:79963859(-) A-I      intronic
chrX:80042152(-) A-I      intronic
chrX:80010340(-) A-I      intronic
chrX:80010424(-) A-I      intronic
chrX:80034479(-) A-I      intronic
chrX:80045039(-) A-I      intronic
chrX:80034620(-) A-I      intronic
chrX:80029820(-) A-I      intronic
chrX:80045601(-) A-I      intronic
chrX:80010348(-) A-I      intronic
chrX:80045639(-) A-I      intronic
chrX:80056987(-) A-I      intronic
chrX:80041522(-) A-I      intronic
chrX:80035090(-) A-I      intronic
chrX:80057234(-) A-I      intronic
chrX:80033130(-) A-I      intronic
chrX:80056910(-) A-I      intronic
chrX:80053405(-) A-I      intronic
chrX:80051901(-) A-I      intronic
chrX:80059797(-) A-I      intronic
chrX:80045602(-) A-I      intronic
chrX:80010288(-) A-I      intronic
chrX:80010407(-) A-I      intronic
chrX:80016540(-) A-I      intronic
chrX:80042281(-) A-I      intronic
chrX:80045553(-) A-I      intronic
chrX:80041446(-) A-I      intronic
chrX:80041344(-) A-I      intronic
chrX:80045070(-) A-I      intronic
chrX:80057743(-) A-I      intronic
chrX:80056843(-) A-I      intronic
chrX:80014282(-) A-I      intronic
chrX:80033064(-) A-I      intronic
chrX:80059822(-) A-I      intronic
chrX:80051335(-) A-I      intronic
chrX:80029854(-) A-I      intronic
chrX:80045515(-) A-I      intronic
chrX:80045561(-) A-I      intronic
chrX:80052425(-) A-I      intronic
chrX:79963843(-) A-I      intronic
chrX:80041417(-) A-I      intronic
chrX:79969829(-) A-I      intronic
chrX:80035066(-) A-I      intronic
chrX:80045080(-) A-I      intronic
chrX:80042196(-) A-I      intronic
chrX:80045573(-) A-I      intronic
chrX:80034315(-) A-I      intronic
chrX:80009042(-) A-I      intronic
chrX:80041276(-) A-I      intronic
chrX:80035092(-) A-I      intronic
chrX:80033135(-) A-I      intronic
chrX:80007660(-) A-I      intronic
chrX:80051741(-) A-I      intronic
chrX:80016519(-) A-I      intronic
chrX:80045641(-) A-I      intronic
chrX:80045512(-) A-I      intronic
chrX:80045557(-) A-I      intronic
chrX:80056816(-) A-I      intronic
chrX:80059901(-) A-I      intronic
chrX:80032941(-) A-I      intronic
chrX:80042151(-) A-I      intronic
chrX:80061241(-) A-I      intronic
chrX:80034970(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BRWD3
chrX:80006320(-) A-G intron -    22484847
chrX:80007627(-) A-G intron -    22484847
chrX:80041429(-) A-G intron -    22484847
chrX:80042110(-) A-G intron -    22484847
chrX:80042111(-) A-G intron -    22484847
chrX:80042196(-) A-G intron -    22484847
chrX:80042281(-) A-G intron -    22484847
chrX:80045601(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BRWD3
chrX:79931816-79931817(-) m6A 3'UTR       24981863//22608085
chrX:79931827-79931828(-) m6A 3'UTR       24981863//22608085
chrX:79931842-79931843(-) m6A 3'UTR       24284625//24981863//22608085
chrX:79931870-79931871(-) m6A 3'UTR       24284625//24981863//22608085
chrX:79931956-79931957(-) m6A 3'UTR       24284625//22608085
chrX:79932016-79932017(-) m6A 3'UTR       22608085
chrX:79932176-79932177(-) Cm CDS       -
chrX:79932250-79932251(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22608085
chrX:79932264-79932265(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22575960//22608085
chrX:79932271-79932272(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22575960//22608085
chrX:79932287-79932288(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22575960//22608085
chrX:79932517-79932518(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22608085
chrX:79932557-79932558(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932569-79932570(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932574-79932575(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932600-79932601(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932625-79932626(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932733-79932734(-) m6A CDS       24284625//24981863//28052920//27371828//22575960//22608085
chrX:79932765-79932766(-) m6A CDS//exon       24284625//24981863//28052920//27371828//22608085
chrX:79932794-79932795(-) m6A CDS//exon       24284625//24981863//28052920//27371828//22608085
chrX:79932811-79932812(-) m6A CDS//exon       24284625//24981863//28052920//27371828//22608085
chrX:79932845-79932846(-) m6A CDS//exon       24284625//24981863//27371828//22608085
chrX:79936843-79936844(-) m6A CDS//exon       24981863//22608085
chrX:79959083-79959084(-) m6A CDS//exon       24981863
chrX:79960187-79960188(-) m6A CDS//exon       24981863
chrX:79960197-79960198(-) m6A CDS//exon       24981863
chrX:79960269-79960270(-) m6A CDS//exon       24981863
chrX:79960278-79960279(-) m6A CDS//exon       24981863
chrX:79960316-79960317(-) m6A CDS//exon       24981863
chrX:79971729-79971730(-) m6A CDS//exon       24981863
chrX:79975048-79975049(-) m6A CDS//exon       24981863
chrX:79975055-79975056(-) m6A CDS//exon       24981863
chrX:79975060-79975061(-) m6A CDS//exon       24981863
chrX:79980471-79980472(-) m6A CDS       -
chrX:79980486-79980487(-) m6A CDS       -
chrX:79980563-79980564(-) m6A CDS       -
chrX:79985459-79985460(-) Am CDS       -
chrX:80064765-80064766(-) m6A CDS//exon       27773536
chrX:80065068-80065069(-) m6A 5'UTR//exon       -
chrX:80065100-80065101(-) m6A 5'UTR//exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate BRWD3
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome HeLa cells     24205503
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: BRWD3

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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