Detail Information

Basic Information:


  VIRBase ID:  

VHID00517304

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           TMED4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p TMED4
miRBase
Accession/Entrez ID		 MIMAT0001581 222068
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - ERS25//GMP25iso//HNLF//p24a3//p24alpha3

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMED4
chr7:44618327(-) A-I      3'UTR
chr7:44618330(-) A-I      3'UTR
chr7:44618341(-) A-I      3'UTR
chr7:44618356(-) A-I      3'UTR
chr7:44618365(-) A-I      3'UTR
chr7:44618440(-) A-I      3'UTR
chr7:44618459(-) A-I      3'UTR
chr7:44618248(-) A-I      3'UTR
chr7:44618321(-) A-I      3'UTR
chr7:44618285(-) A-I      3'UTR
chr7:44618317(-) A-I      3'UTR
chr7:44618343(-) A-I      3'UTR
chr7:44618427(-) A-I      3'UTR
chr7:44618381(-) A-I      3'UTR
chr7:44618299(-) A-I      3'UTR
chr7:44618230(-) A-I      3'UTR
chr7:44618282(-) A-I      3'UTR
chr7:44618353(-) A-I      3'UTR
chr7:44618308(-) A-I      3'UTR
chr7:44618382(-) A-I      3'UTR
chr7:44618378(-) A-I      3'UTR
chr7:44618262(-) A-I      3'UTR
chr7:44618273(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMED4
chr7:44620289(-) A-I intron -    21960545
chr7:44619821(-) A-G intron -    22484847
chr7:44619833(-) A-G intron -    22484847
chr7:44619843(-) A-G intron -    22484847
chr7:44619885(-) A-G intron -    22484847
chr7:44619897(-) A-G intron -    22484847
chr7:44619911(-) A-G intron -    22484847
chr7:44620001(-) A-G intron -    22484847
chr7:44620289(-) A-G intron -    22484847
chr7:44620301(-) A-G intron -    22484847
chr7:44620302(-) A-G intron -    22484847
chr7:44620311(-) A-G intron -    22484847
chr7:44620381(-) A-G intron -    22484847
chr7:44620424(-) A-G intron -    22484847
chr7:44620470(-) A-G intron -    22484847
chr7:44620500(-) A-G intron -    22484847
chr7:44620508(-) A-G intron -    22484847
chr7:44620546(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMED4
chr7:44617497-44617498(-) m6A 3'UTR       27773535
chr7:44617590-44617591(-) m6A 3'UTR       27773535
chr7:44617630-44617631(-) m6A 3'UTR       27773535
chr7:44617699-44617700(-) m6A 3'UTR       22575960
chr7:44617769-44617770(-) m6A 3'UTR       25456834//24981863//22575960
chr7:44617795-44617796(-) m6A 3'UTR       25456834//24981863//22575960
chr7:44617807-44617808(-) m6A 3'UTR       25456834//24981863//22575960
chr7:44618259-44618260(-) m6A 3'UTR       24209618
chr7:44619154-44619155(-) m6A CDS       27371828
chr7:44619509-44619510(-) m6A 3'UTR//exon//intron       27371828
chr7:44620108-44620109(-) m6A 3'UTR//exon//intron       27773535
chr7:44620126-44620127(-) m6A 3'UTR//exon//intron       27773535
chr7:44621334-44621335(-) m6A CDS//exon       27773535
chr7:44621657-44621658(-) m6A CDS//exon       24981863//27371828//27773536
chr7:44621696-44621697(-) m6A CDS//exon       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TMED4
Cytosol HeLa-S3 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: TMED4

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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