Detail Information

Basic Information:


  VIRBase ID:  

VHID00517006

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           FAAP20:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p FAAP20
miRBase
Accession/Entrez ID		 MIMAT0001581 199990
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - C1orf86//FP7162

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FAAP20
chr1:2119024(-) A-I      intronic
chr1:2118811(-) A-I      intronic
chr1:2120418(-) A-I      intronic
chr1:2120280(-) A-I      intronic
chr1:2118907(-) A-I      intronic
chr1:2120263(-) A-I      intronic
chr1:2120274(-) A-I      intronic
chr1:2118791(-) A-I      intronic
chr1:2118948(-) A-I      intronic
chr1:2118796(-) A-I      intronic
chr1:2118980(-) A-I      intronic
chr1:2118962(-) A-I      intronic
chr1:2118801(-) A-I      intronic
chr1:2118809(-) A-I      intronic
chr1:2120381(-) A-I      intronic
chr1:2118937(-) A-I      intronic
chr1:2118921(-) A-I      intronic
chr1:2118936(-) A-I      intronic
chr1:2118970(-) A-I      intronic
chr1:2118820(-) A-I      intronic
chr1:2118849(-) A-I      intronic
chr1:2118855(-) A-I      intronic
chr1:2118841(-) A-I      intronic
chr1:2120382(-) A-I      intronic
chr1:2132998(-) A-I      intronic
chr1:2118754(-) A-I      intronic
chr1:2118741(-) A-I      intronic
chr1:2118946(-) A-I      intronic
chr1:2118920(-) A-I      intronic
chr1:2118961(-) A-I      intronic
chr1:2120306(-) A-I      intronic
chr1:2118882(-) A-I      intronic
chr1:2119016(-) A-I      intronic
chr1:2118842(-) A-I      intronic
chr1:2123012(-) A-I      intronic
chr1:2118816(-) A-I      intronic
chr1:2118755(-) A-I      intronic
chr1:2120442(-) A-I      intronic
chr1:2118947(-) A-I      intronic
chr1:2120251(-) A-I      intronic
chr1:2124285(-) A-I      5'UTR
chr1:2120255(-) A-I      intronic
chr1:2120200(-) A-I      intronic
chr1:2120036(-) A-I      intronic
chr1:2118922(-) A-I      intronic
chr1:2118840(-) A-I      intronic
chr1:2118881(-) A-I      intronic
chr1:2120296(-) A-I      intronic
chr1:2118989(-) A-I      intronic
chr1:2132995(-) A-I      intronic
chr1:2118919(-) A-I      intronic
chr1:2120188(-) A-I      intronic
chr1:2133991(-) A-I      intronic
chr1:2119015(-) A-I      intronic
chr1:2119029(-) A-I      intronic
chr1:2118892(-) A-I      intronic
chr1:2120277(-) A-I      intronic
chr1:2118872(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FAAP20
chr1:2115929-2115930(-) m6A 3'UTR//exon       24981863//27773535
chr1:2116011-2116012(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr1:2116077-2116078(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//22608085
chr1:2116099-2116100(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//27773536//22608085
chr1:2116142-2116143(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//27773536//22608085
chr1:2116158-2116159(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr1:2116233-2116234(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr1:2116391-2116392(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:2116427-2116428(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:2116616-2116617(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773536//22575960//22608085
chr1:2116724-2116725(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr1:2116818-2116819(-) m6A 3'UTR//CDS//exon       24284625//25456834//24981863
chr1:2117464-2117465(-) m6A 3'UTR//intron       24284625
chr1:2118391-2118392(-) m6A 3'UTR//intron       24981863
chr1:2118428-2118429(-) m6A 3'UTR//intron       24981863
chr1:2118473-2118474(-) m6A 3'UTR//intron       24981863
chr1:2118487-2118488(-) m6A 3'UTR//intron       24981863//27371828
chr1:2121108-2121109(-) m6A 3'UTR//exon//intron       24284625//24981863//27773536
chr1:2121403-2121404(-) m6A exon//intron       -
chr1:2121472-2121473(-) m6A exon//intron       -
chr1:2121680-2121681(-) m6A exon//intron       27773536
chr1:2121853-2121854(-) m6A exon//intron       27773536
chr1:2121899-2121900(-) m6A exon//intron       27773536
chr1:2122084-2122085(-) m6A exon//intron       25456834//27371828//22575960//22608085
chr1:2122154-2122155(-) m6A exon//intron       24284625//24209618//25456834//24981863//27371828//22608085
chr1:2122219-2122220(-) m6A exon//intron       24284625//24209618//25456834//24981863//27371828//22608085
chr1:2122234-2122235(-) m6A exon//intron       24284625//24209618//25456834//24981863//27371828//22608085
chr1:2122242-2122243(-) m6A exon//intron       24284625//24209618//25456834//24981863//27371828//22608085
chr1:2122298-2122299(-) m6A exon//intron       24284625//25456834//24981863//27371828//22608085
chr1:2122335-2122336(-) m6A exon//intron       24284625//25456834//24981863//27371828//27773536//22608085
chr1:2122387-2122388(-) m6A exon//intron       24284625//25456834//27371828//27773536//22608085
chr1:2122508-2122509(-) m6A exon//intron       25456834//27773536//22608085
chr1:2122613-2122614(-) m6A exon//intron       27773536
chr1:2122621-2122622(-) m6A exon//intron       27773536
chr1:2122641-2122642(-) m6A exon//intron       27773536
chr1:2122695-2122696(-) m6A exon//intron       27773536
chr1:2122715-2122716(-) m6A exon//intron       27773536
chr1:2122978-2122979(-) m6A exon//intron       24209618
chr1:2123013-2123014(-) m6A exon//intron       24209618
chr1:2123314-2123315(-) m6A exon//intron       24284625
chr1:2123333-2123334(-) m6A exon//intron       22608085
chr1:2123385-2123386(-) m6A 3'UTR//exon//intron       22608085
chr1:2123409-2123410(-) m6A 3'UTR//exon//intron       22608085
chr1:2123536-2123537(-) m6A 3'UTR//exon//intron       24209618//25456834//24981863//27371828//27773536//22608085
chr1:2123548-2123549(-) m6A 3'UTR//exon//intron       24209618//25456834//24981863//27371828//27773536//22608085
chr1:2123597-2123598(-) m6A 3'UTR//exon//intron       24209618//25456834//24981863//27371828//22608085
chr1:2123614-2123615(-) m6A 3'UTR//exon//intron       24209618//25456834//24981863//27371828//22608085
chr1:2123650-2123651(-) m6A 3'UTR//exon//intron       24209618//25456834//24981863//27371828//22608085
chr1:2123671-2123672(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr1:2123716-2123717(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr1:2123722-2123723(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr1:2123756-2123757(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr1:2123838-2123839(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//22608085
chr1:2123883-2123884(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr1:2123905-2123906(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr1:2123915-2123916(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr1:2124065-2124066(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr1:2124079-2124080(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr1:2124405-2124406(-) m6A CDS//exon//intron       -
chr1:2124454-2124455(-) m6A exon//intron       -
chr1:2125269-2125270(-) m6A CDS//exon       24284625//27371828//27773536
chr1:2125285-2125286(-) m6A CDS//exon       24284625//27371828//27773536
chr1:2125297-2125298(-) m6A CDS//exon       24284625//27371828//27773536
chr1:2125304-2125305(-) m6A CDS//exon       24284625//27371828//27773536
chr1:2125439-2125440(-) m6A CDS//exon//intron       24284625//27371828//27773536
chr1:2129449-2129450(-) m6A exon       24209618//24981863
chr1:2129458-2129459(-) m6A exon       24981863
chr1:2143512-2143513(-) m6A intron       24981863
chr1:2143540-2143541(-) m6A intron       24981863
chr1:2143563-2143564(-) m6A intron       24981863
chr1:2143698-2143699(-) m6A exon//intron       25456834//24981863
chr1:2143751-2143752(-) m6A exon//intron       25456834//24981863
chr1:2143785-2143786(-) m6A exon//intron       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate FAAP20
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: FAAP20

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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