Detail Information

Basic Information:


  VIRBase ID:  

VHID00516820

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           LONRF2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p LONRF2
miRBase
Accession/Entrez ID		 MIMAT0001581 164832
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - RNF192

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LONRF2
chr2:100922655(-) A-I      intronic
chr2:100922648(-) A-I      intronic
chr2:100923450(-) A-I      intronic
chr2:100923561(-) A-I      intronic
chr2:100924613(-) A-I      intronic
chr2:100924642(-) A-I      intronic
chr2:100906538(-) A-I      intronic
chr2:100923562(-) A-I      intronic
chr2:100923521(-) A-I      intronic
chr2:100920749(-) A-I      intronic
chr2:100924710(-) A-I      intronic
chr2:100922579(-) A-I      intronic
chr2:100924750(-) A-I      intronic
chr2:100923654(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED LONRF2
chr2:100920613(-) A-I intron -    21960545
chr2:100924750(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LONRF2
chr2:100890443-100890444(-) m6A 3'UTR       22608085
chr2:100891259-100891260(-) m6A 3'UTR       24981863
chr2:100891525-100891526(-) m6A 3'UTR       24981863//22608085
chr2:100891556-100891557(-) m6A 3'UTR       24981863//22608085
chr2:100891566-100891567(-) m6A 3'UTR       24981863//22608085
chr2:100891576-100891577(-) m6A 3'UTR       24981863//22608085
chr2:100891612-100891613(-) m6A 3'UTR       24981863//22608085
chr2:100891649-100891650(-) m6A 3'UTR       24981863//22608085
chr2:100891699-100891700(-) m6A 3'UTR       24981863//22608085
chr2:100891746-100891747(-) m6A 3'UTR       24981863//22608085
chr2:100891822-100891823(-) m6A 3'UTR       24981863//27371828//22608085
chr2:100897729-100897730(-) m6A 3'UTR       24981863
chr2:100897739-100897740(-) m6A 3'UTR       24981863
chr2:100897750-100897751(-) m6A 3'UTR       24981863
chr2:100897758-100897759(-) m6A 3'UTR       24981863
chr2:100897764-100897765(-) m6A 3'UTR       24981863
chr2:100897784-100897785(-) m6A 3'UTR       24981863
chr2:100900349-100900350(-) m6A 3'UTR       22608085
chr2:100900362-100900363(-) m6A 3'UTR       22608085
chr2:100900469-100900470(-) m6A 3'UTR       22608085
chr2:100900531-100900532(-) m6A 3'UTR       24981863//22608085
chr2:100900628-100900629(-) m6A 3'UTR       24981863//22608085
chr2:100938580-100938581(-) m6A 5'UTR       27773536
chr2:100938645-100938646(-) m6A 5'UTR       27773536
chr2:100938855-100938856(-) m6A 5'UTR       27371828//27773536
chr2:100938911-100938912(-) m6A 5'UTR       27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate LONRF2
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: LONRF2

Evidence Support:


Strong-Evidence RISC-IP
Prediction-Evidence miRanda//PITA
Support Database ViRBase//VmiReg

References:


PMID 20585629 Target region 5'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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