Detail Information

Basic Information:


  VIRBase ID:  

VHID00516803

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           SDE2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p SDE2
miRBase
Accession/Entrez ID		 MIMAT0001581 163859
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - C1orf55//dJ671D7.1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SDE2
chr1:226185301(-) A-I      intronic
chr1:226173964(-) A-I      intronic
chr1:226174882(-) A-I      intronic
chr1:226174883(-) A-I      intronic
chr1:226174901(-) A-I      intronic
chr1:226181563(-) A-I      intronic
chr1:226174850(-) A-I      intronic
chr1:226181568(-) A-I      intronic
chr1:226181986(-) A-I      intronic
chr1:226171349(-) A-I      3'UTR
chr1:226171334(-) A-I      3'UTR
chr1:226172277(-) A-I      3'UTR
chr1:226185665(-) A-I      intronic
chr1:226185405(-) A-I      intronic
chr1:226185398(-) A-I      intronic
chr1:226185321(-) A-I      intronic
chr1:226185310(-) A-I      intronic
chr1:226185304(-) A-I      intronic
chr1:226185299(-) A-I      intronic
chr1:226185268(-) A-I      intronic
chr1:226185263(-) A-I      intronic
chr1:226185693(-) A-I      intronic
chr1:226177230(-) A-I      intronic
chr1:226182601(-) A-I      intronic
chr1:226173847(-) A-I      intronic
chr1:226171262(-) A-I      3'UTR
chr1:226173908(-) A-I      intronic
chr1:226172503(-) A-I      3'UTR
chr1:226185766(-) A-I      intronic
chr1:226185746(-) A-I      intronic
chr1:226173935(-) A-I      intronic
chr1:226182659(-) A-I      intronic
chr1:226173947(-) A-I      intronic
chr1:226182633(-) A-I      intronic
chr1:226182709(-) A-I      intronic
chr1:226182650(-) A-I      intronic
chr1:226185279(-) A-I      intronic
chr1:226185392(-) A-I      intronic
chr1:226181582(-) A-I      intronic
chr1:226185295(-) A-I      intronic
chr1:226171340(-) A-I      3'UTR
chr1:226182597(-) A-I      intronic
chr1:226185427(-) A-I      intronic
chr1:226177297(-) A-I      intronic
chr1:226185259(-) A-I      intronic
chr1:226173819(-) A-I      intronic
chr1:226173812(-) A-I      intronic
chr1:226172464(-) A-I      3'UTR
chr1:226172255(-) A-I      3'UTR
chr1:226172322(-) A-I      3'UTR
chr1:226180134(-) A-I      NonSyn:Glu->Gly
chr1:226185291(-) A-I      intronic
chr1:226185745(-) A-I      intronic
chr1:226185334(-) A-I      intronic
chr1:226185627(-) A-I      intronic
chr1:226181673(-) A-I      intronic
chr1:226181665(-) A-I      intronic
chr1:226181581(-) A-I      intronic
chr1:226185374(-) A-I      intronic
chr1:226181916(-) A-I      intronic
chr1:226185671(-) A-I      intronic
chr1:226181608(-) A-I      intronic
chr1:226181957(-) A-I      intronic
chr1:226181845(-) A-I      intronic
chr1:226173867(-) A-I      intronic
chr1:226185311(-) A-I      intronic
chr1:226171362(-) A-I      3'UTR
chr1:226185300(-) A-I      intronic
chr1:226171400(-) A-I      3'UTR
chr1:226173938(-) A-I      intronic
chr1:226173925(-) A-I      intronic
chr1:226171826(-) A-I      3'UTR
chr1:226185227(-) A-I      intronic
chr1:226171280(-) A-I      3'UTR
chr1:226185791(-) A-I      intronic
chr1:226171865(-) A-I      3'UTR
chr1:226185228(-) A-I      intronic
chr1:226171341(-) A-I      3'UTR
chr1:226185336(-) A-I      intronic
chr1:226173960(-) A-I      intronic
chr1:226185790(-) A-I      intronic
chr1:226173837(-) A-I      intronic
chr1:226171378(-) A-I      3'UTR
chr1:226173873(-) A-I      intronic
chr1:226185161(-) A-I      intronic
chr1:226173895(-) A-I      intronic
chr1:226173939(-) A-I      intronic
chr1:226173850(-) A-I      intronic
chr1:226171377(-) A-I      3'UTR
chr1:226185597(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SDE2
chr1:226172339-226172340(-) m6A 3'UTR       24284625
chr1:226172938-226172939(-) m6A 3'UTR       27773535//22608085
chr1:226173065-226173066(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226173083-226173084(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226173122-226173123(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226173137-226173138(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226173173-226173174(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226173208-226173209(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226175623-226175624(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226175685-226175686(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226175697-226175698(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226175716-226175717(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226175746-226175747(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226175763-226175764(-) m1A CDS       26863196
chr1:226175775-226175776(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226175784-226175785(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226175843-226175844(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226175890-226175891(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226175906-226175907(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr1:226176066-226176067(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960//22608085
chr1:226176073-226176074(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960//22608085
chr1:226178983-226178984(-) m6A CDS       24981863//27773535//27371828//27773536//22575960//22608085
chr1:226180180-226180181(-) m6A CDS       27773535
chr1:226180249-226180250(-) m6A CDS       27773535
chr1:226180617-226180618(-) m6A CDS       27773535
chr1:226180658-226180659(-) m6A CDS       27773535
chr1:226182985-226182986(-) m6A CDS       27773535
chr1:226182991-226182992(-) m6A CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SDE2
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: SDE2

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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