Basic Information:

  VIRBase ID:  

VHID00516752

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SLFN5:  NM_001330183     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SLFN5
miRBase Accession/Entrez ID	MIMAT0001581	162394
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLFN5	chr17:33590682(+) A-I      intronic chr17:33590643(+) A-I      intronic chr17:33590333(+) A-I      intronic chr17:33590229(+) A-I      intronic chr17:33589808(+) A-I      intronic chr17:33590295(+) A-I      intronic chr17:33590699(+) A-I      intronic chr17:33590291(+) A-I      intronic chr17:33590727(+) A-I      intronic chr17:33590691(+) A-I      intronic chr17:33590711(+) A-I      intronic chr17:33590695(+) A-I      intronic chr17:33590683(+) A-I      intronic chr17:33590692(+) A-I      intronic chr17:33590666(+) A-I      intronic chr17:33589727(+) A-I      intronic chr17:33589320(+) A-I      intronic chr17:33589680(+) A-I      intronic chr17:33578813(+) A-I      intronic chr17:33589696(+) A-I      intronic chr17:33571791(+) A-I      intronic chr17:33589870(+) A-I      intronic chr17:33571786(+) A-I      intronic chr17:33589798(+) A-I      intronic chr17:33590754(+) A-I      intronic chr17:33590738(+) A-I      intronic chr17:33578684(+) A-I      intronic chr17:33590299(+) A-I      intronic chr17:33578826(+) A-I      intronic chr17:33590181(+) A-I      intronic chr17:33578703(+) A-I      intronic chr17:33578953(+) A-I      intronic chr17:33571689(+) A-I      intronic chr17:33590770(+) A-I      intronic chr17:33589252(+) A-I      intronic chr17:33579356(+) A-I      intronic chr17:33588918(+) A-I      intronic chr17:33590772(+) A-I      intronic chr17:33588751(+) A-I      intronic chr17:33588798(+) A-I      intronic chr17:33588427(+) A-I      intronic chr17:33589756(+) A-I      intronic chr17:33590430(+) A-I      intronic chr17:33578685(+) A-I      intronic chr17:33590819(+) A-I      intronic chr17:33590219(+) A-I      intronic chr17:33589815(+) A-I      intronic chr17:33578850(+) A-I      intronic chr17:33578756(+) A-I      intronic chr17:33590686(+) A-I      intronic chr17:33589691(+) A-I      intronic chr17:33590757(+) A-I      intronic chr17:33588872(+) A-I      intronic chr17:33588472(+) A-I      intronic chr17:33590843(+) A-I      intronic chr17:33590230(+) A-I      intronic chr17:33579376(+) A-I      intronic chr17:33588492(+) A-I      intronic chr17:33590777(+) A-I      intronic chr17:33588974(+) A-I      intronic chr17:33571881(+) A-I      intronic chr17:33588597(+) A-I      intronic chr17:33590359(+) A-I      intronic chr17:33588972(+) A-I      intronic chr17:33590818(+) A-I      intronic chr17:33590440(+) A-I      intronic chr17:33590684(+) A-I      intronic chr17:33590250(+) A-I      intronic chr17:33588898(+) A-I      intronic chr17:33588794(+) A-I      intronic chr17:33588609(+) A-I      intronic chr17:33589242(+) A-I      intronic chr17:33588795(+) A-I      intronic chr17:33588775(+) A-I      intronic chr17:33589681(+) A-I      intronic chr17:33590254(+) A-I      intronic chr17:33588834(+) A-I      intronic chr17:33590774(+) A-I      intronic chr17:33579351(+) A-I      intronic chr17:33590840(+) A-I      intronic chr17:33589858(+) A-I      intronic chr17:33588830(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLFN5	chr17:33588472(+) A-G intron -    22484847 chr17:33590254(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLFN5	chr17:33570101-33570102(+) m6A 5'UTR       - chr17:33570153-33570154(+) m6A 5'UTR       24284625//24209618//24981863//22575960//22608085 chr17:33585673-33585674(+) m6A 5'UTR       24284625//24209618//24981863//22575960//22608085 chr17:33585737-33585738(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33585781-33585782(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr17:33585803-33585804(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr17:33585822-33585823(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr17:33585899-33585900(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33585986-33585987(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33586016-33586017(+) m6A CDS       24284625//24209618//24981863//22608085 chr17:33586075-33586076(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr17:33586129-33586130(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr17:33586135-33586136(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr17:33586266-33586267(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33586337-33586338(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33586411-33586412(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33586448-33586449(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33586658-33586659(+) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr17:33586671-33586672(+) m6A CDS       24284625//24209618//24981863 chr17:33586693-33586694(+) m6A CDS       24284625//24209618//24981863 chr17:33591210-33591211(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr17:33591247-33591248(+) m6A CDS//intron       24284625//24981863//22608085 chr17:33591268-33591269(+) m6A CDS//intron       24284625//24981863//22608085 chr17:33591276-33591277(+) m6A CDS//intron       24284625//24981863//22608085 chr17:33591402-33591403(+) m6A CDS//intron       24284625//24981863 chr17:33591723-33591724(+) m6A CDS//intron       24284625//24981863//22575960 chr17:33591739-33591740(+) m6A CDS//intron       24284625//24981863//22575960 chr17:33591762-33591763(+) m6A CDS//intron       24284625//24981863//22575960 chr17:33591773-33591774(+) m6A CDS//intron       24284625//24981863//22575960 chr17:33591815-33591816(+) m6A CDS//intron       24284625//22575960 chr17:33591868-33591869(+) m6A CDS//intron       24284625//24981863//22575960 chr17:33591897-33591898(+) m6A CDS//intron       24284625//24981863//22575960 chr17:33592104-33592105(+) m6A CDS       24284625//24209618//24981863//22575960 chr17:33592130-33592131(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960 chr17:33592143-33592144(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960 chr17:33592153-33592154(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960 chr17:33592209-33592210(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960 chr17:33592241-33592242(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960 chr17:33592281-33592282(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863 chr17:33592292-33592293(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863 chr17:33592332-33592333(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr17:33592471-33592472(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr17:33592518-33592519(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr17:33592524-33592525(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr17:33592644-33592645(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr17:33592675-33592676(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr17:33592758-33592759(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960 chr17:33592876-33592877(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr17:33592913-33592914(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr17:33592928-33592929(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr17:33592964-33592965(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr17:33592978-33592979(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr17:33593073-33593074(+) m6A 3'UTR       24284625//24209618//24981863 chr17:33593100-33593101(+) m6A 3'UTR       24284625//24209618//24981863 chr17:33593144-33593145(+) m6A 3'UTR       24284625//24981863 chr17:33593152-33593153(+) m6A 3'UTR       24284625//24981863 chr17:33593280-33593281(+) m6A 3'UTR       24284625 chr17:33593314-33593315(+) m6A 3'UTR       24284625 chr17:33594757-33594758(+) m6A 3'UTR       24981863 chr17:33595353-33595354(+) m6A 3'UTR       24981863 chr17:33595402-33595403(+) m6A 3'UTR       24981863 chr17:33595433-33595434(+) m6A 3'UTR       24981863 chr17:33595440-33595441(+) m6A 3'UTR       24981863 chr17:33596511-33596512(+) m6A 3'UTR       24981863 chr17:33596547-33596548(+) m6A 3'UTR       24981863 chr17:33596618-33596619(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SLFN5	Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SLFN5

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.