Basic Information:

  VIRBase ID:  

VHID00516616

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          AMOT:  NM_001113490     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	AMOT
miRBase Accession/Entrez ID	MIMAT0001581	154796
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AMOT	chrX:112066244(-) A-I      NonSyn:Ile->Met chrX:112066194(-) A-I      NonSyn:Asn->Ser chrX:112066236(-) A-I      NonSyn:Gln->Arg chrX:112025169(-) A-I      intronic chrX:112025179(-) A-I      intronic chrX:112025182(-) A-I      intronic chrX:112025192(-) A-I      intronic chrX:112066229(-) A-I      Syn:Thr->Thr chrX:112066246(-) A-I      NonSyn:Ile->Val chrX:112025389(-) A-I      intronic chrX:112024621(-) A-I      intronic chrX:112025390(-) A-I      intronic chrX:112025214(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AMOT	chrX:112020322-112020323(-) m6A 3'UTR       24981863 chrX:112021531-112021532(-) m6A 3'UTR       24981863//22608085 chrX:112021588-112021589(-) m6A 3'UTR       24981863//22608085 chrX:112021629-112021630(-) m6A 3'UTR       24981863//22608085 chrX:112021659-112021660(-) m6A 3'UTR       24981863//22608085 chrX:112021672-112021673(-) m6A 3'UTR       24981863//22608085 chrX:112021707-112021708(-) m6A 3'UTR       24981863//22608085 chrX:112021817-112021818(-) Gm CDS       - chrX:112021833-112021834(-) m6A CDS       22608085 chrX:112021853-112021854(-) m6A CDS       22608085 chrX:112022380-112022381(-) m6A CDS       27773536 chrX:112022758-112022759(-) m6A CDS       25456834//24981863//27773536//22608085 chrX:112022763-112022764(-) m6A CDS       25456834//24981863//27773536//22608085 chrX:112022785-112022786(-) m6A CDS       25456834//24981863//27773536//22608085 chrX:112022799-112022800(-) m6A CDS       25456834//24981863//27773536//22608085 chrX:112022812-112022813(-) m6A CDS       25456834//24981863//27773536//22608085 chrX:112022889-112022890(-) m6A CDS       22608085 chrX:112024338-112024339(-) m6A CDS       24981863 chrX:112035100-112035101(-) m6A CDS       24981863 chrX:112048250-112048251(-) m6A CDS       24981863//27773535 chrX:112053145-112053146(-) m6A CDS       24981863//27773535 chrX:112053156-112053157(-) m6A CDS       24981863 chrX:112053202-112053203(-) m6A CDS       24981863//27773536 chrX:112054529-112054530(-) m6A CDS       24981863//27773536 chrX:112054580-112054581(-) m6A CDS       24981863//27773536 chrX:112054614-112054615(-) m6A CDS       24981863 chrX:112058946-112058947(-) m6A 5'UTR//CDS       27773535 chrX:112065548-112065549(-) m6A CDS//intron       - chrX:112065652-112065653(-) m6A CDS//intron       24981863//27773535//22608085 chrX:112065860-112065861(-) m6A CDS//intron       24209618//25456834//24981863//27773535//27773536//22608085 chrX:112065868-112065869(-) m6A CDS//intron       24209618//25456834//24981863//27773535//27773536//22608085 chrX:112065927-112065928(-) m6A CDS//intron       24209618//25456834//24981863//27773536//22608085 chrX:112066039-112066040(-) m6A CDS//intron       24209618//24981863//22608085 chrX:112066088-112066089(-) m6A CDS//intron       24209618//24981863//22608085 chrX:112066117-112066118(-) m6A CDS//intron       24209618//24981863//22608085 chrX:112066157-112066158(-) m6A CDS//intron       24209618 chrX:112075583-112075584(-) m6A 5'UTR//exon       27773536 chrX:112083734-112083735(-) m6A 5'UTR//exon       27773536 chrX:112083976-112083977(-) m6A 5'UTR       24981863//27773535//22608085 chrX:112083984-112083985(-) m6A 5'UTR       24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	AMOT	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: AMOT

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.