Basic Information:

  VIRBase ID:  

VHID00516552

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CCDC50:  NM_178335     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CCDC50
miRBase Accession/Entrez ID	MIMAT0001581	152137
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	C3orf6//DFNA44//YMER

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCDC50	chr3:191110237(+) A-I      3'UTR chr3:191110668(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCDC50	chr3:191055259(+) G-A intron -    22484847 chr3:191081863(+) A-T intron -    22484847 chr3:191088286(+) T-G intron -    22484847 chr3:191088287(+) G-T intron -    22484847 chr3:191110789(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCDC50	chr3:191047039-191047040(+) m6A 5'UTR       24981863 chr3:191047103-191047104(+) m6A 5'UTR       24981863 chr3:191047279-191047280(+) m6A 5'UTR       24981863 chr3:191075909-191075910(+) m6A CDS       24981863//27773535 chr3:191078860-191078861(+) m6A CDS       24981863//27773535 chr3:191078868-191078869(+) m6A CDS       24981863//27773535 chr3:191087763-191087764(+) m6A CDS//exon       24981863//27773535//22608085 chr3:191087862-191087863(+) m6A exon//intron       24981863//27773535 chr3:191087875-191087876(+) m6A exon//intron       24981863//27773535 chr3:191087912-191087913(+) m6A exon//intron       27773535 chr3:191092899-191092900(+) m6A CDS//intron       25456834//22608085 chr3:191092908-191092909(+) m6A CDS//intron       25456834//22608085 chr3:191092927-191092928(+) m6A CDS//intron       25456834//24981863//22608085 chr3:191092950-191092951(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191092956-191092957(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191092970-191092971(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191092986-191092987(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191093042-191093043(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191093106-191093107(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191093167-191093168(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191093185-191093186(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191093202-191093203(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191093285-191093286(+) m6A CDS//intron       25456834//24981863//22608085 chr3:191093316-191093317(+) m6A CDS//intron       25456834//24981863//22608085 chr3:191093329-191093330(+) m6A CDS//intron       25456834//24981863//22608085 chr3:191098041-191098042(+) m6A CDS       24981863//27773535 chr3:191098056-191098057(+) m6A CDS       24981863//27773535 chr3:191098488-191098489(+) m6A CDS       24981863//27773535 chr3:191098692-191098693(+) m6A CDS       24981863//27773535 chr3:191098707-191098708(+) m6A CDS       24981863//27773535 chr3:191100540-191100541(+) m6A CDS       24981863//27773535 chr3:191100581-191100582(+) m6A CDS       24981863//27773535 chr3:191107340-191107341(+) m6A CDS       24981863//27773535//22608085 chr3:191109542-191109543(+) m6A CDS       24981863//27773535//22608085 chr3:191109551-191109552(+) m6A 3'UTR       24981863//27773535//22608085 chr3:191109576-191109577(+) m6A 3'UTR       24981863//27773535//22608085 chr3:191109809-191109810(+) m6A 3'UTR       27773535 chr3:191109819-191109820(+) m6A 3'UTR       27773535 chr3:191109910-191109911(+) m6A 3'UTR       27773535 chr3:191113376-191113377(+) m6A 3'UTR       24981863//22608085 chr3:191113391-191113392(+) m6A 3'UTR       24981863//22608085 chr3:191113408-191113409(+) m6A 3'UTR       24981863//22608085 chr3:191113472-191113473(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CCDC50	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CCDC50

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.