Basic Information:

  VIRBase ID:  

VHID00516545

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          RNF38:  NM_194332     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	RNF38
miRBase Accession/Entrez ID	MIMAT0001581	152006
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RNF38	chr9:36365503(-) A-I      intronic chr9:36369297(-) A-I      intronic chr9:36362255(-) A-I      intronic chr9:36378446(-) A-I      intronic chr9:36372940(-) A-I      intronic chr9:36369322(-) A-I      intronic chr9:36369327(-) A-I      intronic chr9:36369382(-) A-I      intronic chr9:36369422(-) A-I      intronic chr9:36369478(-) A-I      intronic chr9:36372928(-) A-I      intronic chr9:36378394(-) A-I      intronic chr9:36378383(-) A-I      intronic chr9:36371576(-) A-I      intronic chr9:36370810(-) A-I      intronic chr9:36346300(-) A-I      intronic chr9:36362308(-) A-I      intronic chr9:36346279(-) A-I      intronic chr9:36346275(-) A-I      intronic chr9:36369486(-) A-I      intronic chr9:36350018(-) A-I      intronic chr9:36347961(-) A-I      intronic chr9:36394031(-) A-I      intronic chr9:36394029(-) A-I      intronic chr9:36383318(-) A-I      intronic chr9:36350042(-) A-I      intronic chr9:36378445(-) A-I      intronic chr9:36346947(-) A-I      intronic chr9:36346392(-) A-I      intronic chr9:36346384(-) A-I      intronic chr9:36369456(-) A-I      intronic chr9:36361051(-) A-I      intronic chr9:36361040(-) A-I      intronic chr9:36361029(-) A-I      intronic chr9:36346343(-) A-I      intronic chr9:36341686(-) A-I      intronic chr9:36362759(-) A-I      intronic chr9:36361020(-) A-I      intronic chr9:36349954(-) A-I      intronic chr9:36365437(-) A-I      intronic chr9:36346406(-) A-I      intronic chr9:36346363(-) A-I      intronic chr9:36362231(-) A-I      intronic chr9:36362188(-) A-I      intronic chr9:36362097(-) A-I      intronic chr9:36361363(-) A-I      intronic chr9:36362763(-) A-I      intronic chr9:36361241(-) A-I      intronic chr9:36358925(-) A-I      intronic chr9:36365320(-) A-I      intronic chr9:36365361(-) A-I      intronic chr9:36362268(-) A-I      intronic chr9:36365441(-) A-I      intronic chr9:36349910(-) A-I      intronic chr9:36339244(-) A-I      3'UTR chr9:36367863(-) A-I      intronic chr9:36346391(-) A-I      intronic chr9:36397248(-) A-I      intronic chr9:36347079(-) A-I      intronic chr9:36350057(-) A-I      intronic chr9:36362272(-) A-I      intronic chr9:36370747(-) A-I      intronic chr9:36371581(-) A-I      intronic chr9:36346911(-) A-I      intronic chr9:36370757(-) A-I      intronic chr9:36365526(-) A-I      intronic chr9:36349860(-) A-I      intronic chr9:36348464(-) A-I      intronic chr9:36359900(-) A-I      intronic chr9:36365693(-) A-I      intronic chr9:36365381(-) A-I      intronic chr9:36362094(-) A-I      intronic chr9:36358969(-) A-I      intronic chr9:36365841(-) A-I      intronic chr9:36350065(-) A-I      intronic chr9:36362191(-) A-I      intronic chr9:36363939(-) A-I      intronic chr9:36341639(-) A-I      intronic chr9:36397249(-) A-I      intronic chr9:36346477(-) A-I      intronic chr9:36363209(-) A-I      intronic chr9:36370737(-) A-I      intronic chr9:36350019(-) A-I      intronic chr9:36346327(-) A-I      intronic chr9:36370854(-) A-I      intronic chr9:36340501(-) A-I      intronic chr9:36361281(-) A-I      intronic chr9:36371607(-) A-I      intronic chr9:36346311(-) A-I      intronic chr9:36346952(-) A-I      intronic chr9:36346313(-) A-I      intronic chr9:36374656(-) A-I      intronic chr9:36346461(-) A-I      intronic chr9:36346271(-) A-I      intronic chr9:36350066(-) A-I      intronic chr9:36349980(-) A-I      intronic chr9:36361234(-) A-I      intronic chr9:36362769(-) A-I      intronic chr9:36373191(-) A-I      intronic chr9:36346880(-) A-I      intronic chr9:36350087(-) A-I      intronic chr9:36365367(-) A-I      intronic chr9:36348456(-) A-I      intronic chr9:36361287(-) A-I      intronic chr9:36345152(-) A-I      intronic chr9:36370905(-) A-I      intronic chr9:36362197(-) A-I      intronic chr9:36346935(-) A-I      intronic chr9:36365483(-) A-I      intronic chr9:36365842(-) A-I      intronic chr9:36346438(-) A-I      intronic chr9:36346274(-) A-I      intronic chr9:36370646(-) A-I      intronic chr9:36346407(-) A-I      intronic chr9:36349948(-) A-I      intronic chr9:36350056(-) A-I      intronic chr9:36358956(-) A-I      intronic chr9:36365482(-) A-I      intronic chr9:36347054(-) A-I      intronic chr9:36347017(-) A-I      intronic chr9:36365384(-) A-I      intronic chr9:36374647(-) A-I      intronic chr9:36346299(-) A-I      intronic chr9:36347964(-) A-I      intronic chr9:36349953(-) A-I      intronic chr9:36378338(-) A-I      intronic chr9:36371608(-) A-I      intronic chr9:36374669(-) A-I      intronic chr9:36362771(-) A-I      intronic chr9:36365565(-) A-I      intronic chr9:36349944(-) A-I      intronic chr9:36373121(-) A-I      intronic chr9:36370652(-) A-I      intronic chr9:36347009(-) A-I      intronic chr9:36361432(-) A-I      intronic chr9:36365307(-) A-I      intronic chr9:36365496(-) A-I      intronic chr9:36371590(-) A-I      intronic chr9:36370846(-) A-I      intronic chr9:36346439(-) A-I      intronic chr9:36380500(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RNF38	chr9:36346949(-) A-I intron -    22327324 chr9:36346274(-) A-G intron -    22484847 chr9:36346299(-) A-G intron -    22484847 chr9:36346313(-) A-G intron -    22484847 chr9:36346407(-) A-G intron -    22484847 chr9:36346438(-) A-G intron -    22484847 chr9:36346439(-) A-G intron -    22484847 chr9:36346477(-) A-G intron -    22484847 chr9:36346880(-) A-G intron -    22484847 chr9:36346912(-) A-G intron -    22484847 chr9:36346949(-) A-G intron -    22484847 chr9:36347884(-) A-G intron -    22484847 chr9:36349860(-) A-G intron -    22484847 chr9:36350019(-) A-G intron -    22484847 chr9:36350057(-) A-G intron -    22484847 chr9:36350087(-) A-G intron -    22484847 chr9:36365565(-) A-G intron -    22484847 chr9:36365681(-) C-A intron -    22484847 chr9:36371581(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RNF38	chr9:36339631-36339632(-) m6A 3'UTR       24981863 chr9:36339680-36339681(-) m6A 3'UTR       24981863 chr9:36339692-36339693(-) m6A 3'UTR       24981863 chr9:36353286-36353287(-) m6A CDS       27773535 chr9:36353298-36353299(-) m6A CDS       27773535 chr9:36356316-36356317(-) m6A CDS       27773535 chr9:36357804-36357805(-) m6A CDS//exon       27773535 chr9:36357926-36357927(-) m6A CDS//exon       27773535 chr9:36369857-36369858(-) m6A CDS//exon       27773535//27371828 chr9:36372552-36372553(-) m6A CDS//intron       27371828 chr9:36376097-36376098(-) m6A 5'UTR//CDS//exon       24981863//27773535 chr9:36390506-36390507(-) m6A 5'UTR//CDS//exon//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RNF38	Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: RNF38

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.