Basic Information:

  VIRBase ID:  

VHID00516512

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          KLHL23:  NM_144711     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	KLHL23
miRBase Accession/Entrez ID	MIMAT0001581	151230
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	DITHP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KLHL23	chr2:170560901(+) A-I      intronic chr2:170560869(+) A-I      intronic chr2:170560861(+) A-I      intronic chr2:170559714(+) A-I      intronic chr2:170559710(+) A-I      intronic chr2:170559695(+) A-I      intronic chr2:170559693(+) A-I      intronic chr2:170559692(+) A-I      intronic chr2:170559690(+) A-I      intronic chr2:170560897(+) A-I      intronic chr2:170559688(+) A-I      intronic chr2:170559671(+) A-I      intronic chr2:170559654(+) A-I      intronic chr2:170603727(+) A-I      intronic chr2:170603696(+) A-I      intronic chr2:170603670(+) A-I      intronic chr2:170601210(+) A-I      intronic chr2:170581346(+) A-I      intronic chr2:170581338(+) A-I      intronic chr2:170581327(+) A-I      intronic chr2:170581324(+) A-I      intronic chr2:170581321(+) A-I      intronic chr2:170566060(+) A-I      intronic chr2:170566055(+) A-I      intronic chr2:170559880(+) A-I      intronic chr2:170559834(+) A-I      intronic chr2:170558962(+) A-I      intronic chr2:170558961(+) A-I      intronic chr2:170559724(+) A-I      intronic chr2:170559725(+) A-I      intronic chr2:170559726(+) A-I      intronic chr2:170559729(+) A-I      intronic chr2:170560865(+) A-I      intronic chr2:170560968(+) A-I      intronic chr2:170560961(+) A-I      intronic chr2:170560945(+) A-I      intronic chr2:170560935(+) A-I      intronic chr2:170560934(+) A-I      intronic chr2:170560913(+) A-I      intronic chr2:170560911(+) A-I      intronic chr2:170601186(+) A-I      intronic chr2:170581926(+) A-I      intronic chr2:170581914(+) A-I      intronic chr2:170581913(+) A-I      intronic chr2:170577468(+) A-I      intronic chr2:170601636(+) A-I      intronic chr2:170563068(+) A-I      intronic chr2:170562045(+) A-I      intronic chr2:170560065(+) A-I      intronic chr2:170560053(+) A-I      intronic chr2:170559021(+) A-I      intronic chr2:170558975(+) A-I      intronic chr2:170558935(+) A-I      intronic chr2:170558898(+) A-I      intronic chr2:170601540(+) A-I      intronic chr2:170601834(+) A-I      intronic chr2:170601835(+) A-I      intronic chr2:170601850(+) A-I      intronic chr2:170563619(+) A-I      intronic chr2:170601876(+) A-I      intronic chr2:170601896(+) A-I      intronic chr2:170582390(+) A-I      intronic chr2:170601610(+) A-I      intronic chr2:170585478(+) A-I      intronic chr2:170586638(+) A-I      intronic chr2:170603695(+) A-I      intronic chr2:170603703(+) A-I      intronic chr2:170603801(+) A-I      intronic chr2:170601837(+) A-I      intronic chr2:170559858(+) A-I      intronic chr2:170559843(+) A-I      intronic chr2:170601902(+) A-I      intronic chr2:170566193(+) A-I      intronic chr2:170601187(+) A-I      intronic chr2:170562009(+) A-I      intronic chr2:170581886(+) A-I      intronic chr2:170563626(+) A-I      intronic chr2:170558876(+) A-I      intronic chr2:170562105(+) A-I      intronic chr2:170559852(+) A-I      intronic chr2:170603688(+) A-I      intronic chr2:170559002(+) A-I      intronic chr2:170558969(+) A-I      intronic chr2:170566217(+) A-I      intronic chr2:170601468(+) A-I      intronic chr2:170604378(+) A-I      intronic chr2:170601968(+) A-I      intronic chr2:170558928(+) A-I      intronic chr2:170601143(+) A-I      intronic chr2:170563511(+) A-I      intronic chr2:170577587(+) A-I      intronic chr2:170581881(+) A-I      intronic chr2:170582608(+) A-I      intronic chr2:170594176(+) A-I      intronic chr2:170601194(+) A-I      intronic chr2:170604394(+) A-I      intronic chr2:170561900(+) A-I      intronic chr2:170603802(+) A-I      intronic chr2:170566082(+) A-I      intronic chr2:170562110(+) A-I      intronic chr2:170566025(+) A-I      intronic chr2:170566020(+) A-I      intronic chr2:170566059(+) A-I      intronic chr2:170601208(+) A-I      intronic chr2:170577459(+) A-I      intronic chr2:170566085(+) A-I      intronic chr2:170587199(+) A-I      intronic chr2:170604511(+) A-I      intronic chr2:170601319(+) A-I      intronic chr2:170558884(+) A-I      intronic chr2:170565983(+) A-I      intronic chr2:170604076(+) A-I      intronic chr2:170566226(+) A-I      intronic chr2:170603671(+) A-I      intronic chr2:170601289(+) A-I      intronic chr2:170601249(+) A-I      intronic chr2:170558903(+) A-I      intronic chr2:170566179(+) A-I      intronic chr2:170578282(+) A-I      intronic chr2:170566097(+) A-I      intronic chr2:170560098(+) A-I      intronic chr2:170559835(+) A-I      intronic chr2:170560072(+) A-I      intronic chr2:170566067(+) A-I      intronic chr2:170583459(+) A-I      intronic chr2:170559828(+) A-I      intronic chr2:170603763(+) A-I      intronic chr2:170563319(+) A-I      intronic chr2:170603754(+) A-I      intronic chr2:170558976(+) A-I      intronic chr2:170601198(+) A-I      intronic chr2:170578288(+) A-I      intronic chr2:170604549(+) A-I      intronic chr2:170563107(+) A-I      intronic chr2:170601162(+) A-I      intronic chr2:170559813(+) A-I      intronic chr2:170601274(+) A-I      intronic chr2:170566103(+) A-I      intronic chr2:170559015(+) A-I      intronic chr2:170560093(+) A-I      intronic chr2:170604026(+) A-I      intronic chr2:170601266(+) A-I      intronic chr2:170560111(+) A-I      intronic chr2:170596719(+) A-I      intronic chr2:170604377(+) A-I      intronic chr2:170604064(+) A-I      intronic chr2:170581778(+) A-I      intronic chr2:170566081(+) A-I      intronic chr2:170577581(+) A-I      intronic chr2:170562058(+) A-I      intronic chr2:170603759(+) A-I      intronic chr2:170601203(+) A-I      intronic chr2:170589310(+) A-I      intronic chr2:170562041(+) A-I      intronic chr2:170585318(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KLHL23	chr2:170551077-170551078(+) m6A 5'UTR       25456834//24981863//22608085 chr2:170551082-170551083(+) m6A 5'UTR       25456834//24981863//22608085 chr2:170551127-170551128(+) m6A 5'UTR       25456834//24981863 chr2:170553949-170553950(+) m6A 5'UTR       24209618 chr2:170553969-170553970(+) m6A 5'UTR       24209618 chr2:170554463-170554464(+) m6A 5'UTR//intron       25456834 chr2:170557478-170557479(+) m6A intron       22608085 chr2:170557582-170557583(+) m6A intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:170557613-170557614(+) m6A intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:170557666-170557667(+) m6A intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:170557720-170557721(+) m6A intron       24284625//24209618//24981863//22608085 chr2:170590400-170590401(+) m6A 5'UTR//intron       25456834//24981863 chr2:170590444-170590445(+) m6A 5'UTR//intron       25456834//24981863 chr2:170591538-170591539(+) m6A CDS//intron       24981863//22608085 chr2:170591605-170591606(+) m6A CDS//intron       24284625//24981863//26404942//22608085 chr2:170591760-170591761(+) m6A CDS//intron       24284625//24981863//22608085 chr2:170591982-170591983(+) m6A CDS//intron       24981863//22608085 chr2:170592145-170592146(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22608085 chr2:170592232-170592233(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22608085 chr2:170592480-170592481(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr2:170592571-170592572(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr2:170592725-170592726(+) m6A CDS//intron       24209618//22608085 chr2:170605983-170605984(+) m6A 5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22608085 chr2:170606016-170606017(+) m6A 5'UTR//CDS//intron       24284625//24209618//25456834//24981863//22608085 chr2:170608096-170608097(+) m6A 3'UTR//intron       27773535 chr2:170608168-170608169(+) m6A 3'UTR//intron       27773535 chr2:170608183-170608184(+) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	KLHL23	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: KLHL23

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.