Detail Information

Basic Information:


  VIRBase ID:  

VHID00516445

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           EXOC8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p EXOC8
miRBase
Accession/Entrez ID		 MIMAT0001581 149371
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - EXO84//Exo84p//NEDMISB//SEC84

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR EXOC8
chr1:231470972(-) A-I      3'UTR
chr1:231470953(-) A-I      3'UTR
chr1:231470940(-) A-I      3'UTR
chr1:231470904(-) A-I      3'UTR
chr1:231470789(-) A-I      3'UTR
chr1:231470820(-) A-I      3'UTR
chr1:231470858(-) A-I      3'UTR
chr1:231470886(-) A-I      3'UTR
chr1:231470891(-) A-I      3'UTR
chr1:231470846(-) A-I      3'UTR
chr1:231470864(-) A-I      3'UTR
chr1:231470929(-) A-I      3'UTR
chr1:231470874(-) A-I      3'UTR
chr1:231470871(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED EXOC8
chr1:231470998(-) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase EXOC8
chr1:231468613-231468614(-) m6A 3'UTR       27773535
chr1:231470533-231470534(-) m6A 3'UTR       22608085
chr1:231470608-231470609(-) m6A 3'UTR       24981863//22608085
chr1:231470644-231470645(-) m6A 3'UTR       24981863//22608085
chr1:231470866-231470867(-) m6A 3'UTR       27773535
chr1:231470981-231470982(-) m6A 3'UTR       24284625//27773535
chr1:231471216-231471217(-) m6A 3'UTR       27773535
chr1:231471355-231471356(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231471394-231471395(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231471441-231471442(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231471466-231471467(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:231471625-231471626(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr1:231471656-231471657(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr1:231471755-231471756(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr1:231471790-231471791(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr1:231471842-231471843(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231471883-231471884(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231472083-231472084(-) m6A CDS       24284625//24981863//27773535//27371828//22575960//22608085
chr1:231472190-231472191(-) m6A CDS       24284625//24981863//27773535//27371828//22575960//22608085
chr1:231472300-231472301(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr1:231472357-231472358(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr1:231472381-231472382(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231472400-231472401(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231472436-231472437(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231472463-231472464(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231472499-231472500(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:231472534-231472535(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231472541-231472542(-) m1A CDS       26863410
chr1:231472655-231472656(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231472745-231472746(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr1:231472763-231472764(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr1:231472907-231472908(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231472928-231472929(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231472951-231472952(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231473099-231473100(-) m6A CDS       24284625//27371828//27773536//22608085
chr1:231473294-231473295(-) m6A CDS       24284625//24981863//27371828//27773536//22608085
chr1:231473318-231473319(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085
chr1:231473372-231473373(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr1:231473378-231473379(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr1:231473471-231473472(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr1:231473502-231473503(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr1:231473548-231473549(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate EXOC8
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: EXOC8

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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