Basic Information:

  VIRBase ID:  

VHID00516334

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          RTN4RL1:  NM_178568     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	RTN4RL1
miRBase Accession/Entrez ID	MIMAT0001581	146760
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	NgR3//NGRH2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RTN4RL1	chr17:1868584(-) A-I      intronic chr17:1868625(-) A-I      intronic chr17:1868624(-) A-I      intronic chr17:1868588(-) A-I      intronic chr17:1847888(-) A-I      intronic chr17:1873363(-) A-I      intronic chr17:1856921(-) A-I      intronic chr17:1903880(-) A-I      intronic chr17:1868150(-) A-I      intronic chr17:1885822(-) A-I      intronic chr17:1882623(-) A-I      intronic chr17:1867224(-) A-I      intronic chr17:1886621(-) A-I      intronic chr17:1856136(-) A-I      intronic chr17:1856664(-) A-I      intronic chr17:1916344(-) A-I      intronic chr17:1913967(-) A-I      intronic chr17:1855720(-) A-I      intronic chr17:1925696(-) A-I      intronic chr17:1873358(-) A-I      intronic chr17:1868193(-) A-I      intronic chr17:1886519(-) A-I      intronic chr17:1868207(-) A-I      intronic chr17:1925062(-) A-I      intronic chr17:1913949(-) A-I      intronic chr17:1882362(-) A-I      intronic chr17:1916226(-) A-I      intronic chr17:1925391(-) A-I      intronic chr17:1862913(-) A-I      intronic chr17:1913927(-) A-I      intronic chr17:1908957(-) A-I      intronic chr17:1855706(-) A-I      intronic chr17:1913944(-) A-I      intronic chr17:1904070(-) A-I      intronic chr17:1907473(-) A-I      intronic chr17:1895445(-) A-I      intronic chr17:1914506(-) A-I      intronic chr17:1872424(-) A-I      intronic chr17:1896280(-) A-I      intronic chr17:1866343(-) A-I      intronic chr17:1908931(-) A-I      intronic chr17:1916320(-) A-I      intronic chr17:1910100(-) A-I      intronic chr17:1886972(-) A-I      intronic chr17:1908547(-) A-I      intronic chr17:1904676(-) A-I      intronic chr17:1916228(-) A-I      intronic chr17:1872580(-) A-I      intronic chr17:1876564(-) A-I      intronic chr17:1876548(-) A-I      intronic chr17:1925713(-) A-I      intronic chr17:1909187(-) A-I      intronic chr17:1886586(-) A-I      intronic chr17:1913984(-) A-I      intronic chr17:1909980(-) A-I      intronic chr17:1908926(-) A-I      intronic chr17:1856249(-) A-I      intronic chr17:1873383(-) A-I      intronic chr17:1873528(-) A-I      intronic chr17:1913990(-) A-I      intronic chr17:1841736(-) A-I      intronic chr17:1908886(-) A-I      intronic chr17:1884634(-) A-I      intronic chr17:1873316(-) A-I      intronic chr17:1858669(-) A-I      intronic chr17:1882636(-) A-I      intronic chr17:1854779(-) A-I      intronic chr17:1885431(-) A-I      intronic chr17:1868337(-) A-I      intronic chr17:1883460(-) A-I      intronic chr17:1913671(-) A-I      intronic chr17:1924987(-) A-I      intronic chr17:1861431(-) A-I      intronic chr17:1883486(-) A-I      intronic chr17:1886833(-) A-I      intronic chr17:1854019(-) A-I      intronic chr17:1925719(-) A-I      intronic chr17:1903736(-) A-I      intronic chr17:1858632(-) A-I      intronic chr17:1914147(-) A-I      intronic chr17:1907120(-) A-I      intronic chr17:1925741(-) A-I      intronic chr17:1856996(-) A-I      intronic chr17:1886477(-) A-I      intronic chr17:1886412(-) A-I      intronic chr17:1868469(-) A-I      intronic chr17:1858652(-) A-I      intronic chr17:1868221(-) A-I      intronic chr17:1882688(-) A-I      intronic chr17:1860207(-) A-I      intronic chr17:1858647(-) A-I      intronic chr17:1916216(-) A-I      intronic chr17:1911500(-) A-I      intronic chr17:1858750(-) A-I      intronic chr17:1858844(-) A-I      intronic chr17:1876422(-) A-I      intronic chr17:1913506(-) A-I      intronic chr17:1883564(-) A-I      intronic chr17:1892922(-) A-I      intronic chr17:1893900(-) A-I      intronic chr17:1857041(-) A-I      intronic chr17:1910125(-) A-I      intronic chr17:1867215(-) A-I      intronic chr17:1866074(-) A-I      intronic chr17:1914080(-) A-I      intronic chr17:1868276(-) A-I      intronic chr17:1841843(-) A-I      intronic chr17:1908944(-) A-I      intronic chr17:1908964(-) A-I      intronic chr17:1908392(-) A-I      intronic chr17:1841733(-) A-I      intronic chr17:1883611(-) A-I      intronic chr17:1875596(-) A-I      intronic chr17:1913649(-) A-I      intronic chr17:1916261(-) A-I      intronic chr17:1882719(-) A-I      intronic chr17:1876534(-) A-I      intronic chr17:1842100(-) A-I      intronic chr17:1908368(-) A-I      intronic chr17:1902628(-) A-I      intronic chr17:1882749(-) A-I      intronic chr17:1868594(-) A-I      intronic chr17:1925042(-) A-I      intronic chr17:1908438(-) A-I      intronic chr17:1866324(-) A-I      intronic chr17:1866244(-) A-I      intronic chr17:1885548(-) A-I      intronic chr17:1841734(-) A-I      intronic chr17:1867616(-) A-I      intronic chr17:1865914(-) A-I      intronic chr17:1908914(-) A-I      intronic chr17:1886892(-) A-I      intronic chr17:1925718(-) A-I      intronic chr17:1876704(-) A-I      intronic chr17:1914141(-) A-I      intronic chr17:1864977(-) A-I      intronic chr17:1908902(-) A-I      intronic chr17:1866062(-) A-I      intronic chr17:1887774(-) A-I      intronic chr17:1871032(-) A-I      intronic chr17:1885543(-) A-I      intronic chr17:1842196(-) A-I      intronic chr17:1865760(-) A-I      intronic chr17:1871030(-) A-I      intronic chr17:1912606(-) A-I      intronic chr17:1886504(-) A-I      intronic chr17:1925673(-) A-I      intronic chr17:1842179(-) A-I      intronic chr17:1876400(-) A-I      intronic chr17:1884669(-) A-I      intronic chr17:1882765(-) A-I      intronic chr17:1876726(-) A-I      intronic chr17:1892964(-) A-I      intronic chr17:1908556(-) A-I      intronic chr17:1907154(-) A-I      intronic chr17:1908574(-) A-I      intronic chr17:1919412(-) A-I      intronic chr17:1842088(-) A-I      intronic chr17:1867203(-) A-I      intronic chr17:1893976(-) A-I      intronic chr17:1916315(-) A-I      intronic chr17:1856654(-) A-I      intronic chr17:1912537(-) A-I      intronic chr17:1865203(-) A-I      intronic chr17:1883327(-) A-I      intronic chr17:1864965(-) A-I      intronic chr17:1908974(-) A-I      intronic chr17:1862997(-) A-I      intronic chr17:1924372(-) A-I      intronic chr17:1903501(-) A-I      intronic chr17:1883496(-) A-I      intronic chr17:1875544(-) A-I      intronic chr17:1871207(-) A-I      intronic chr17:1883582(-) A-I      intronic chr17:1892410(-) A-I      intronic chr17:1886417(-) A-I      intronic chr17:1913708(-) A-I      intronic chr17:1881885(-) A-I      intronic chr17:1885637(-) A-I      intronic chr17:1866356(-) A-I      intronic chr17:1916170(-) A-I      intronic chr17:1909728(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RTN4RL1	chr17:1838156-1838157(-) m6A 3'UTR       25456834//27371828 chr17:1838176-1838177(-) m6A 3'UTR       25456834//27371828 chr17:1838197-1838198(-) m6A 3'UTR       25456834//27371828 chr17:1838258-1838259(-) m6A 3'UTR       25456834//27371828 chr17:1838288-1838289(-) m6A 3'UTR       27371828 chr17:1838541-1838542(-) m6A 3'UTR       27773535 chr17:1838828-1838829(-) m6A 3'UTR       25456834//27773535//22608085 chr17:1838852-1838853(-) m6A 3'UTR       25456834//27773535//22608085 chr17:1838885-1838886(-) m6A 3'UTR       25456834//27773535//22608085 chr17:1838917-1838918(-) m6A 3'UTR       27773535 chr17:1838931-1838932(-) m6A 3'UTR       27773535 chr17:1838943-1838944(-) m6A 3'UTR       27773535 chr17:1839129-1839130(-) m6A 3'UTR       24284625//27773535 chr17:1839171-1839172(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085 chr17:1839199-1839200(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085 chr17:1839377-1839378(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085 chr17:1839480-1839481(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1839545-1839546(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1839626-1839627(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085 chr17:1839647-1839648(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085 chr17:1839742-1839743(-) m6A 3'UTR       24284625//25456834//24981863//27371828//22608085 chr17:1839786-1839787(-) m6A 3'UTR       24284625//25456834//24981863//27371828//22608085 chr17:1839818-1839819(-) m6A CDS       24284625//25456834//24981863//27371828//22608085 chr17:1839893-1839894(-) m6A CDS       24284625//25456834//24981863//27371828//22608085 chr17:1839967-1839968(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085 chr17:1839979-1839980(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085 chr17:1839999-1840000(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085 chr17:1840033-1840034(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr17:1840051-1840052(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr17:1840131-1840132(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1840197-1840198(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1840207-1840208(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1840216-1840217(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1840240-1840241(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1840342-1840343(-) m6A CDS       24284625//25456834//27371828//22608085 chr17:1840495-1840496(-) m6A CDS       24284625//27371828 chr17:1840516-1840517(-) m6A CDS       27371828 chr17:1840522-1840523(-) m6A CDS       27371828 chr17:1840757-1840758(-) m6A CDS       27371828 chr17:1840798-1840799(-) m6A CDS       27371828 chr17:1840858-1840859(-) m6A CDS       27371828 chr17:1840927-1840928(-) m6A CDS       27371828 chr17:1840951-1840952(-) m6A CDS       27371828 chr17:1841032-1841033(-) m6A CDS       24284625//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RTN4RL1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: RTN4RL1

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//RNAHybrid
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.