Basic Information:

  VIRBase ID:  

VHID00516305

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          NRG4:  NM_138573     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	NRG4
miRBase Accession/Entrez ID	MIMAT0001581	145957
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HRG4

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NRG4	chr15:76259970(-) A-I      intronic chr15:76259985(-) A-I      intronic chr15:76293441(-) A-I      intronic chr15:76259982(-) A-I      intronic chr15:76259980(-) A-I      intronic chr15:76260070(-) A-I      intronic chr15:76287434(-) A-I      intronic chr15:76241612(-) A-I      intronic chr15:76241284(-) A-I      intronic chr15:76283102(-) A-I      intronic chr15:76241604(-) A-I      intronic chr15:76241714(-) A-I      intronic chr15:76281480(-) A-I      intronic chr15:76283092(-) A-I      intronic chr15:76293624(-) A-I      intronic chr15:76292484(-) A-I      intronic chr15:76241676(-) A-I      intronic chr15:76241700(-) A-I      intronic chr15:76240765(-) A-I      intronic chr15:76246101(-) A-I      intronic chr15:76241689(-) A-I      intronic chr15:76283138(-) A-I      intronic chr15:76241309(-) A-I      intronic chr15:76241536(-) A-I      intronic chr15:76240874(-) A-I      intronic chr15:76245044(-) A-I      intronic chr15:76241640(-) A-I      intronic chr15:76280698(-) A-I      intronic chr15:76283193(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NRG4	chr15:76233371-76233372(-) m6A 3'UTR//intron       24981863//22608085 chr15:76234116-76234117(-) m6A 3'UTR//intron       27773535//22608085 chr15:76234155-76234156(-) m6A 3'UTR//intron       27773535//22608085 chr15:76234408-76234409(-) m6A 3'UTR//intron       27773535 chr15:76234489-76234490(-) m6A 3'UTR//intron       24981863//27773535 chr15:76235206-76235207(-) m6A 3'UTR//intron       27773535 chr15:76235221-76235222(-) m6A 3'UTR//intron       27773535 chr15:76235296-76235297(-) m6A 3'UTR//intron       27773535 chr15:76235392-76235393(-) m6A 3'UTR//intron       24981863//27773535//22575960 chr15:76235398-76235399(-) m6A 3'UTR//intron       24981863//27773535//22575960 chr15:76235525-76235526(-) m6A 3'UTR//intron       24284625//24981863//27773535//22575960 chr15:76235534-76235535(-) m6A 3'UTR//intron       24284625//24981863//27773535//22575960 chr15:76235584-76235585(-) m6A 3'UTR//intron       24284625//24981863//27773535 chr15:76235625-76235626(-) m6A 3'UTR//intron       24284625//24981863//27773535 chr15:76235666-76235667(-) m6A 3'UTR//intron       24284625//27773535//22575960 chr15:76235846-76235847(-) m6A 3'UTR//intron       27773535 chr15:76235921-76235922(-) m6A 3'UTR//exon       27773535 chr15:76235961-76235962(-) m6A 3'UTR//exon       27773535 chr15:76235987-76235988(-) m6A 3'UTR//CDS//exon       27773535 chr15:76238117-76238118(-) m6A exon//intron       27773535 chr15:76238140-76238141(-) m6A exon//intron       27773535 chr15:76243117-76243118(-) m6A intron       27773535 chr15:76243136-76243137(-) m6A intron       27773535 chr15:76243188-76243189(-) m6A intron       27773535 chr15:76243212-76243213(-) m6A intron       27773535 chr15:76243327-76243328(-) m6A intron       27773535 chr15:76243361-76243362(-) m6A intron       27773535 chr15:76303587-76303588(-) m6A 5'UTR       27773535 chr15:76304380-76304381(-) m6A 5'UTR//intron       27773535 chr15:76304385-76304386(-) m6A 5'UTR//intron       27773535 chr15:76304696-76304697(-) m6A 5'UTR//intron       24981863 chr15:76304705-76304706(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NRG4	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: NRG4

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.