Basic Information:

  VIRBase ID:  

VHID00516284

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PRIMA1:  NM_178013     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PRIMA1
miRBase Accession/Entrez ID	MIMAT0001581	145270
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRIMA

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PRIMA1	chr14:94224869(-) A-I      intronic chr14:94243791(-) A-I      intronic chr14:94191495(-) A-I      intronic chr14:94193785(-) A-I      intronic chr14:94243820(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PRIMA1	chr14:94186976-94186977(-) m6A 3'UTR       25456834//24981863 chr14:94187004-94187005(-) m6A 3'UTR       25456834//24981863 chr14:94187058-94187059(-) m6A 3'UTR       25456834//24981863 chr14:94187122-94187123(-) m6A 3'UTR       25456834//24981863 chr14:94187595-94187596(-) m6A 3'UTR       25456834//24981863//27773536 chr14:94187649-94187650(-) m6A 3'UTR       25456834//24981863 chr14:94187689-94187690(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187717-94187718(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187735-94187736(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187756-94187757(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187773-94187774(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187805-94187806(-) m6A 3'UTR//CDS       25456834//24981863//22608085 chr14:94187888-94187889(-) m6A 3'UTR//CDS       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PRIMA1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PRIMA1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.