Basic Information:

  VIRBase ID:  

VHID00516186

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TRPM6:  NM_017662     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TRPM6
miRBase Accession/Entrez ID	MIMAT0001581	140803
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CHAK2//HMGX//HOMG//HOMG1//HSH

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRPM6	chr9:77384226(-) A-I      intronic chr9:77384194(-) A-I      intronic chr9:77384186(-) A-I      intronic chr9:77347940(-) A-I      intronic chr9:77433456(-) A-I      intronic chr9:77433315(-) A-I      intronic chr9:77361020(-) A-I      intronic chr9:77348707(-) A-I      intronic chr9:77467008(-) A-I      intronic chr9:77445633(-) A-I      intronic chr9:77384154(-) A-I      intronic chr9:77348613(-) A-I      intronic chr9:77384268(-) A-I      intronic chr9:77350014(-) A-I      intronic chr9:77408374(-) A-I      intronic chr9:77416245(-) A-I      intronic chr9:77445409(-) A-I      intronic chr9:77445479(-) A-I      intronic chr9:77443709(-) A-I      intronic chr9:77348706(-) A-I      intronic chr9:77401609(-) A-I      intronic chr9:77347947(-) A-I      intronic chr9:77348668(-) A-I      intronic chr9:77408383(-) A-I      intronic chr9:77480793(-) A-I      intronic chr9:77347944(-) A-I      intronic chr9:77443642(-) A-I      intronic chr9:77478664(-) A-I      intronic chr9:77443683(-) A-I      intronic chr9:77348730(-) A-I      intronic chr9:77408373(-) A-I      intronic chr9:77384200(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TRPM6	chr9:77377633(-) A-I exon CDS    19478186

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRPM6	chr9:77339230-77339231(-) m6A 3'UTR       24981863//27773535 chr9:77339351-77339352(-) m6A 3'UTR       24981863 chr9:77339423-77339424(-) m6A 3'UTR       24981863 chr9:77339481-77339482(-) m6A 3'UTR       24981863//27773535 chr9:77339612-77339613(-) m6A CDS       24981863//27773535 chr9:77343161-77343162(-) m6A CDS       24981863 chr9:77377021-77377022(-) m6A CDS       24981863 chr9:77377038-77377039(-) m6A CDS       24981863 chr9:77377099-77377100(-) m6A CDS       24981863//27773535//22608085 chr9:77377122-77377123(-) m6A CDS       24981863//27773535//22608085 chr9:77377166-77377167(-) m6A CDS       24981863//27773535 chr9:77377199-77377200(-) m6A CDS       24981863//27773535 chr9:77377225-77377226(-) m6A CDS       24981863//27773535//22608085 chr9:77377244-77377245(-) m6A CDS       24981863//27773535//22608085 chr9:77377290-77377291(-) m6A CDS       24981863//27773535//22608085 chr9:77377333-77377334(-) m6A CDS       25456834//24981863//27773535//22608085 chr9:77377338-77377339(-) m6A CDS       25456834//24981863//27773535//22608085 chr9:77377380-77377381(-) m6A CDS       25456834//24981863//27773535//22608085 chr9:77377415-77377416(-) m6A CDS       25456834//24981863//27773535 chr9:77377445-77377446(-) m6A CDS       25456834//24981863//27773535 chr9:77377453-77377454(-) m6A CDS       25456834//24981863//27773535 chr9:77377458-77377459(-) m6A CDS       25456834//24981863//27773535 chr9:77377488-77377489(-) m6A CDS       25456834//24981863 chr9:77377508-77377509(-) m6A CDS       24981863 chr9:77377622-77377623(-) m6A CDS       24981863 chr9:77377672-77377673(-) m6A CDS       24981863 chr9:77377842-77377843(-) m6A CDS       24981863 chr9:77377959-77377960(-) m6A CDS       24981863 chr9:77377972-77377973(-) m6A CDS       24981863 chr9:77377990-77377991(-) m6A CDS       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TRPM6	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Membrane K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TRPM6

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.