Detail Information

Basic Information:


  VIRBase ID:  

VHID00516164

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           NOL4L:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p NOL4L
miRBase
Accession/Entrez ID		 MIMAT0001581 140688
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - C20orf112//C20orf113

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NOL4L
chr20:31057215(-) A-I      intronic
chr20:31057283(-) A-I      intronic
chr20:31056640(-) A-I      intronic
chr20:31050625(-) A-I      intronic
chr20:31057201(-) A-I      intronic
chr20:31125678(-) A-I      intronic
chr20:31131192(-) A-I      intronic
chr20:31050491(-) A-I      intronic
chr20:31125696(-) A-I      intronic
chr20:31130203(-) A-I      intronic
chr20:31057469(-) A-I      intronic
chr20:31057401(-) A-I      intronic
chr20:31057373(-) A-I      intronic
chr20:31057342(-) A-I      intronic
chr20:31057323(-) A-I      intronic
chr20:31057312(-) A-I      intronic
chr20:31057290(-) A-I      intronic
chr20:31057286(-) A-I      intronic
chr20:31057272(-) A-I      intronic
chr20:31057271(-) A-I      intronic
chr20:31056702(-) A-I      intronic
chr20:31056553(-) A-I      intronic
chr20:31056454(-) A-I      intronic
chr20:31053891(-) A-I      intronic
chr20:31053887(-) A-I      intronic
chr20:31050525(-) A-I      intronic
chr20:31050466(-) A-I      intronic
chr20:31050465(-) A-I      intronic
chr20:31049504(-) A-I      intronic
chr20:31130309(-) A-I      intronic
chr20:31130319(-) A-I      intronic
chr20:31130423(-) A-I      intronic
chr20:31131249(-) A-I      intronic
chr20:31133028(-) A-I      intronic
chr20:31056619(-) A-I      intronic
chr20:31056656(-) A-I      intronic
chr20:31056645(-) A-I      intronic
chr20:31056655(-) A-I      intronic
chr20:31131470(-) A-I      intronic
chr20:31057447(-) A-I      intronic
chr20:31057446(-) A-I      intronic
chr20:31134204(-) A-I      intronic
chr20:31130295(-) A-I      intronic
chr20:31132988(-) A-I      intronic
chr20:31057203(-) A-I      intronic
chr20:31057248(-) A-I      intronic
chr20:31054043(-) A-I      intronic
chr20:31050586(-) A-I      intronic
chr20:31132989(-) A-I      intronic
chr20:31133006(-) A-I      intronic
chr20:31050451(-) A-I      intronic
chr20:31134378(-) A-I      intronic
chr20:31056639(-) A-I      intronic
chr20:31134020(-) A-I      intronic
chr20:31133075(-) A-I      intronic
chr20:31134341(-) A-I      intronic
chr20:31134153(-) A-I      intronic
chr20:31125761(-) A-I      intronic
chr20:31133848(-) A-I      intronic
chr20:31049397(-) A-I      intronic
chr20:31134334(-) A-I      intronic
chr20:31125742(-) A-I      intronic
chr20:31053935(-) A-I      intronic
chr20:31132992(-) A-I      intronic
chr20:31053998(-) A-I      intronic
chr20:31133069(-) A-I      intronic
chr20:31050669(-) A-I      intronic
chr20:31057406(-) A-I      intronic
chr20:31131454(-) A-I      intronic
chr20:31132993(-) A-I      intronic
chr20:31134515(-) A-I      intronic
chr20:31133007(-) A-I      intronic
chr20:31134287(-) A-I      intronic
chr20:31130254(-) A-I      intronic
chr20:31049354(-) A-I      intronic
chr20:31130210(-) A-I      intronic
chr20:31134148(-) A-I      intronic
chr20:31130428(-) A-I      intronic
chr20:31050453(-) A-I      intronic
chr20:31134404(-) A-I      intronic
chr20:31057247(-) A-I      intronic
chr20:31056459(-) A-I      intronic
chr20:31056554(-) A-I      intronic
chr20:31130445(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NOL4L
chr20:31030866-31030867(-) m6A 3'UTR       27773535
chr20:31030873-31030874(-) m6A 3'UTR       27773535
chr20:31030880-31030881(-) m6A 3'UTR       27773535
chr20:31030898-31030899(-) m6A 3'UTR       27773535
chr20:31031009-31031010(-) m6A 3'UTR       27773535
chr20:31031618-31031619(-) m6A 3'UTR       24981863
chr20:31031640-31031641(-) m6A 3'UTR       24981863
chr20:31031827-31031828(-) m6A 3'UTR       27773535
chr20:31031833-31031834(-) m6A 3'UTR       27773535
chr20:31031892-31031893(-) m6A 3'UTR       27773535
chr20:31032321-31032322(-) m6A 3'UTR       24981863
chr20:31032342-31032343(-) m6A 3'UTR       24981863
chr20:31032359-31032360(-) m6A 3'UTR       24981863
chr20:31033472-31033473(-) m6A 3'UTR       24284625//27773535
chr20:31033481-31033482(-) m6A 3'UTR       24284625//27773535
chr20:31033634-31033635(-) m6A 3'UTR       27773535
chr20:31033969-31033970(-) m6A 3'UTR       27773535
chr20:31033979-31033980(-) m6A 3'UTR       27773535
chr20:31033986-31033987(-) m6A 3'UTR       27773535
chr20:31034326-31034327(-) m6A 3'UTR       24981863
chr20:31034397-31034398(-) m6A 3'UTR       24981863
chr20:31034471-31034472(-) m6A 3'UTR       27773535
chr20:31034492-31034493(-) m6A 3'UTR       27773535
chr20:31034551-31034552(-) m6A 3'UTR       27773535
chr20:31034664-31034665(-) m6A 3'UTR       27773535
chr20:31034692-31034693(-) m6A 3'UTR       27773535
chr20:31034732-31034733(-) m6A 3'UTR       -
chr20:31034994-31034995(-) m6A 3'UTR       24981863//27773535
chr20:31035082-31035083(-) m6A 3'UTR       24284625//24981863//27773535
chr20:31035235-31035236(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr20:31035250-31035251(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr20:31035343-31035344(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr20:31035402-31035403(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr20:31035420-31035421(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960
chr20:31035428-31035429(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960
chr20:31035609-31035610(-) m6A CDS       24284625//24209618//24981863//27773535//27371828
chr20:31040049-31040050(-) m6A CDS       24284625//24209618//24981863//27773535//27371828
chr20:31040056-31040057(-) m6A CDS       24284625//24209618//24981863//27773535//27371828
chr20:31040145-31040146(-) m6A CDS       24284625//24209618//24981863//27773535//27371828
chr20:31040202-31040203(-) m6A CDS       24284625//24209618//27773535//27371828
chr20:31040220-31040221(-) m6A CDS       24284625//24209618//27773535//27371828
chr20:31040736-31040737(-) m6A CDS//exon       24284625//27773535
chr20:31040765-31040766(-) m6A CDS//exon       24284625//27773535
chr20:31040803-31040804(-) m6A CDS//exon       24284625//27773535
chr20:31041403-31041404(-) m6A CDS//exon       27773535
chr20:31041436-31041437(-) m6A CDS//exon       27773535
chr20:31041499-31041500(-) m6A CDS//exon       -
chr20:31041524-31041525(-) m6A CDS//exon       -
chr20:31044071-31044072(-) m6A CDS//exon       24284625
chr20:31044149-31044150(-) m6A CDS//exon       24284625
chr20:31052730-31052731(-) m6A 3'UTR//intron       -
chr20:31052844-31052845(-) m6A 3'UTR//CDS//intron       25456834
chr20:31052865-31052866(-) m6A 3'UTR//CDS//intron       25456834
chr20:31052883-31052884(-) m6A 3'UTR//CDS//intron       25456834
chr20:31062538-31062539(-) m6A 5'UTR//CDS//exon       -
chr20:31097708-31097709(-) m6A CDS//intron       -
chr20:31108715-31108716(-) m6A CDS       27371828
chr20:31115571-31115572(-) m6A CDS//exon       27371828
chr20:31120128-31120129(-) m6A 5'UTR//intron       -
chr20:31136460-31136461(-) m6A exon//intron       27773535
chr20:31136467-31136468(-) m6A exon//intron       27773535
chr20:31136481-31136482(-) m6A exon//intron       -
chr20:31136580-31136581(-) m6A exon//intron       -
chr20:31136590-31136591(-) m6A exon//intron       -
chr20:31172416-31172417(-) m6A 5'UTR//CDS//exon       27371828
chr20:31172508-31172509(-) m6A 5'UTR//CDS//exon       27371828
chr20:31172571-31172572(-) m6A 5'UTR//CDS//exon       24209618//27371828
chr20:31172606-31172607(-) m6A 5'UTR//CDS//exon       24209618//27371828
chr20:31172633-31172634(-) m6A CDS//exon       24209618//27371828
chr20:31172803-31172804(-) m6A 5'UTR//exon       27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate NOL4L
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: NOL4L

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

Starting a new search, please wait ...