Basic Information:

  VIRBase ID:  

VHID00516140

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ASB11:  NM_001012428     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ASB11
miRBase Accession/Entrez ID	MIMAT0001581	140456
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ASB11	chrX:15299311(-) A-I      intronic chrX:15299242(-) A-I      intronic chrX:15299235(-) A-I      intronic chrX:15299151(-) A-I      intronic chrX:15299125(-) A-I      intronic chrX:15299948(-) A-I      3'UTR chrX:15299968(-) A-I      3'UTR chrX:15300035(-) A-I      3'UTR chrX:15299888(-) A-I      3'UTR chrX:15299997(-) A-I      3'UTR chrX:15299916(-) A-I      3'UTR chrX:15299922(-) A-I      3'UTR chrX:15299893(-) A-I      3'UTR chrX:15299206(-) A-I      intronic chrX:15314295(-) A-I      intronic chrX:15299548(-) A-I      intronic chrX:15314373(-) A-I      intronic chrX:15303400(-) A-I      intronic chrX:15299980(-) A-I      3'UTR chrX:15299998(-) A-I      3'UTR chrX:15299984(-) A-I      3'UTR chrX:15299993(-) A-I      3'UTR chrX:15314319(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ASB11	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ASB11

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.