Basic Information:

  VIRBase ID:  

VHID00516124

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          UPRT:  NR_030774     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	UPRT
miRBase Accession/Entrez ID	MIMAT0001581	139596
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	FUR1//UPP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UPRT	chrX:74522424(+) A-I      intronic chrX:74522485(+) A-I      intronic chrX:74522343(+) A-I      intronic chrX:74522474(+) A-I      intronic chrX:74522481(+) A-I      intronic chrX:74522490(+) A-I      intronic chrX:74522435(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UPRT	chrX:74493936-74493937(+) m6A 5'UTR//exon       24981863 chrX:74493962-74493963(+) m6A 5'UTR//exon       24981863 chrX:74494114-74494115(+) m6A CDS//exon       24284625//24209618//22608085 chrX:74494144-74494145(+) m6A CDS//exon       24284625//24209618//22608085 chrX:74494198-74494199(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chrX:74494213-74494214(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chrX:74494282-74494283(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chrX:74494384-74494385(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chrX:74494391-74494392(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chrX:74494401-74494402(+) Cm CDS//exon       - chrX:74519582-74519583(+) m6A 3'UTR//CDS//exon       24981863 chrX:74519596-74519597(+) m6A 3'UTR//CDS//exon       24981863 chrX:74519689-74519690(+) m6A 3'UTR//CDS//exon       24209618 chrX:74523321-74523322(+) m6A 3'UTR//CDS//exon       24981863 chrX:74523935-74523936(+) m6A 3'UTR       - chrX:74524009-74524010(+) m6A 3'UTR       - chrX:74524035-74524036(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	UPRT	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: UPRT

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.