Basic Information:

  VIRBase ID:  

VHID00516009

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          GRPEL2:  NM_152407     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	GRPEL2
miRBase Accession/Entrez ID	MIMAT0001581	134266
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	Mt-GrpE#2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GRPEL2	chr5:148728733(+) A-I      intronic chr5:148726430(+) A-I      intronic chr5:148728719(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GRPEL2	chr5:148725100-148725101(+) m6A 5'UTR       24284625//24981863 chr5:148725214-148725215(+) m6A exon//intron       24284625//24981863 chr5:148725347-148725348(+) m6A exon//intron       - chr5:148727871-148727872(+) m6A CDS//exon       - chr5:148727884-148727885(+) m6A CDS//exon       - chr5:148727899-148727900(+) m6A CDS//exon       - chr5:148727960-148727961(+) m6A CDS//exon       27773535 chr5:148729250-148729251(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:148729264-148729265(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:148729412-148729413(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr5:148730501-148730502(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr5:148730533-148730534(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730570-148730571(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:148730661-148730662(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:148730703-148730704(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:148730763-148730764(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730778-148730779(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730838-148730839(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730859-148730860(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730909-148730910(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085 chr5:148733905-148733906(+) m6A 3'UTR//exon       27773535 chr5:148734025-148734026(+) m6A 3'UTR//exon       24981863//27773535 chr5:148734052-148734053(+) m6A 3'UTR//exon       24981863//27773535 chr5:148734081-148734082(+) m6A 3'UTR//exon       27773535 chr5:148734111-148734112(+) m6A 3'UTR//exon       27773535 chr5:148734125-148734126(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GRPEL2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: GRPEL2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.