Basic Information:

  VIRBase ID:  

VHID00515940

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TRIM71:  NM_001039111     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TRIM71
miRBase Accession/Entrez ID	MIMAT0001581	131405
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HYDCC1//LIN-41//LIN41

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRIM71	chr3:32866115(+) A-I      intronic chr3:32866366(+) A-I      intronic chr3:32866367(+) A-I      intronic chr3:32866387(+) A-I      intronic chr3:32906778(+) A-I      intronic chr3:32918017(+) A-I      intronic chr3:32880317(+) A-I      intronic chr3:32873264(+) A-I      intronic chr3:32866426(+) A-I      intronic chr3:32870777(+) A-I      intronic chr3:32895389(+) A-I      intronic chr3:32867696(+) A-I      intronic chr3:32867735(+) A-I      intronic chr3:32870794(+) A-I      intronic chr3:32872403(+) A-I      intronic chr3:32895235(+) A-I      intronic chr3:32880362(+) A-I      intronic chr3:32879157(+) A-I      intronic chr3:32873815(+) A-I      intronic chr3:32869005(+) A-I      intronic chr3:32868324(+) A-I      intronic chr3:32925932(+) A-I      intronic chr3:32895297(+) A-I      intronic chr3:32871563(+) A-I      intronic chr3:32924209(+) A-I      intronic chr3:32895298(+) A-I      intronic chr3:32906766(+) A-I      intronic chr3:32915988(+) A-I      intronic chr3:32915972(+) A-I      intronic chr3:32879074(+) A-I      intronic chr3:32883343(+) A-I      intronic chr3:32866133(+) A-I      intronic chr3:32873168(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TRIM71	chr3:32879074(+) A-G intron -    22484847 chr3:32933339(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRIM71	chr3:32859590-32859591(+) m6A CDS       25456834 chr3:32931981-32931982(+) m6A CDS       25456834 chr3:32931999-32932000(+) m6A CDS       25456834//24981863 chr3:32932031-32932032(+) m6A CDS       25456834//24981863 chr3:32932334-32932335(+) m6A CDS       25456834//24981863//22608085 chr3:32932413-32932414(+) m6A CDS       25456834//24981863//22608085 chr3:32932539-32932540(+) m6A CDS       25456834//22608085 chr3:32932713-32932714(+) m6A CDS       25456834//24981863//22608085 chr3:32932778-32932779(+) m6A CDS       25456834//24981863//22608085 chr3:32932848-32932849(+) m6A CDS       25456834//24981863//22608085 chr3:32932857-32932858(+) m6A CDS       25456834//24981863//22608085 chr3:32932899-32932900(+) m6A CDS       25456834//24981863//22608085 chr3:32933103-32933104(+) m6A CDS       25456834//24981863//22608085 chr3:32933139-32933140(+) m6A CDS       25456834//24981863//22608085 chr3:32933220-32933221(+) m6A CDS       25456834//24981863//22608085 chr3:32933271-32933272(+) m6A CDS       25456834//24981863//22608085 chr3:32939122-32939123(+) m6A 3'UTR       27773535 chr3:32939225-32939226(+) m6A 3'UTR       27773535 chr3:32939246-32939247(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TRIM71	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TRIM71

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.