Basic Information:

  VIRBase ID:  

VHID00515765

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          FBXO27:  NM_178820     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	FBXO27
miRBase Accession/Entrez ID	MIMAT0001581	126433
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	FBG5//Fbx27

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FBXO27	chr19:39518404(-) A-I      intronic chr19:39518420(-) A-I      intronic chr19:39515018(-) A-I      3'UTR chr19:39515268(-) A-I      3'UTR chr19:39515437(-) A-I      3'UTR chr19:39519587(-) A-I      intronic chr19:39517384(-) A-I      intronic chr19:39519801(-) A-I      intronic chr19:39518381(-) A-I      intronic chr19:39518429(-) A-I      intronic chr19:39516437(-) A-I      intronic chr19:39519807(-) A-I      intronic chr19:39514996(-) A-I      3'UTR chr19:39516483(-) A-I      intronic chr19:39515365(-) A-I      3'UTR chr19:39515060(-) A-I      3'UTR chr19:39518743(-) A-I      intronic chr19:39518373(-) A-I      intronic chr19:39515301(-) A-I      3'UTR chr19:39516617(-) A-I      intronic chr19:39515144(-) A-I      3'UTR chr19:39517229(-) A-I      intronic chr19:39517251(-) A-I      intronic chr19:39515176(-) A-I      3'UTR chr19:39515291(-) A-I      3'UTR chr19:39515015(-) A-I      3'UTR chr19:39515002(-) A-I      3'UTR chr19:39518400(-) A-I      intronic chr19:39515064(-) A-I      3'UTR chr19:39517234(-) A-I      intronic chr19:39518427(-) A-I      intronic chr19:39521381(-) A-I      intronic chr19:39515274(-) A-I      3'UTR chr19:39521286(-) A-I      intronic chr19:39514927(-) A-I      3'UTR chr19:39520570(-) A-I      intronic chr19:39518832(-) A-I      intronic chr19:39517252(-) A-I      intronic chr19:39521340(-) A-I      intronic chr19:39516546(-) A-I      intronic chr19:39521345(-) A-I      intronic chr19:39517200(-) A-I      intronic chr19:39521410(-) A-I      intronic chr19:39521407(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FBXO27	chr19:39515595-39515596(-) m6A 3'UTR//intron       27773535 chr19:39515637-39515638(-) m6A 3'UTR//intron       27773535 chr19:39515725-39515726(-) m6A 3'UTR//intron       27773535 chr19:39515802-39515803(-) m6A 3'UTR//intron       27773535 chr19:39515883-39515884(-) m6A 3'UTR//intron       27773535 chr19:39515983-39515984(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//22608085 chr19:39515996-39515997(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//22608085 chr19:39516026-39516027(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//22608085 chr19:39516126-39516127(-) m6A CDS//exon//intron       27773535 chr19:39516140-39516141(-) m6A CDS//exon//intron       27773535 chr19:39521709-39521710(-) m6A CDS//exon       27773535 chr19:39521737-39521738(-) m6A CDS//exon       27773535 chr19:39521897-39521898(-) m6A CDS//exon       24981863 chr19:39521902-39521903(-) m6A CDS//exon       24981863 chr19:39521989-39521990(-) m6A exon//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FBXO27	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: FBXO27

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.