Basic Information:

  VIRBase ID:  

VHID00515505

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PIK3AP1:  NM_152309     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PIK3AP1
miRBase Accession/Entrez ID	MIMAT0001581	118788
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	BCAP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIK3AP1	chr10:98467323(-) A-I      intronic chr10:98450224(-) A-I      intronic chr10:98467758(-) A-I      intronic chr10:98469286(-) A-I      intronic chr10:98469195(-) A-I      intronic chr10:98462801(-) A-I      intronic chr10:98364781(-) A-I      intronic chr10:98412912(-) A-I      intronic chr10:98439202(-) A-I      intronic chr10:98439203(-) A-I      intronic chr10:98452222(-) A-I      intronic chr10:98431694(-) A-I      intronic chr10:98413383(-) A-I      intronic chr10:98361737(-) A-I      intronic chr10:98452223(-) A-I      intronic chr10:98452231(-) A-I      intronic chr10:98452268(-) A-I      intronic chr10:98431687(-) A-I      intronic chr10:98454512(-) A-I      intronic chr10:98364790(-) A-I      intronic chr10:98465789(-) A-I      intronic chr10:98412218(-) A-I      intronic chr10:98364799(-) A-I      intronic chr10:98388826(-) A-I      intronic chr10:98420914(-) A-I      intronic chr10:98400491(-) A-I      intronic chr10:98365598(-) A-I      intronic chr10:98420773(-) A-I      intronic chr10:98437946(-) A-I      intronic chr10:98413040(-) A-I      intronic chr10:98462807(-) A-I      intronic chr10:98464429(-) A-I      intronic chr10:98465680(-) A-I      intronic chr10:98412907(-) A-I      intronic chr10:98413304(-) A-I      intronic chr10:98365599(-) A-I      intronic chr10:98415181(-) A-I      intronic chr10:98457403(-) A-I      intronic chr10:98464440(-) A-I      intronic chr10:98415088(-) A-I      intronic chr10:98462924(-) A-I      intronic chr10:98412208(-) A-I      intronic chr10:98395496(-) A-I      intronic chr10:98462722(-) A-I      intronic chr10:98438178(-) A-I      intronic chr10:98365637(-) A-I      intronic chr10:98400647(-) A-I      intronic chr10:98364682(-) A-I      intronic chr10:98415044(-) A-I      intronic chr10:98450291(-) A-I      intronic chr10:98450295(-) A-I      intronic chr10:98437852(-) A-I      intronic chr10:98467322(-) A-I      intronic chr10:98400539(-) A-I      intronic chr10:98388804(-) A-I      intronic chr10:98400475(-) A-I      intronic chr10:98365661(-) A-I      intronic chr10:98468850(-) A-I      intronic chr10:98454307(-) A-I      intronic chr10:98400483(-) A-I      intronic chr10:98464292(-) A-I      intronic chr10:98415004(-) A-I      intronic chr10:98462108(-) A-I      intronic chr10:98468653(-) A-I      intronic chr10:98413370(-) A-I      intronic chr10:98468719(-) A-I      intronic chr10:98462798(-) A-I      intronic chr10:98438109(-) A-I      intronic chr10:98467210(-) A-I      intronic chr10:98412982(-) A-I      intronic chr10:98413159(-) A-I      intronic chr10:98412920(-) A-I      intronic chr10:98412905(-) A-I      intronic chr10:98464363(-) A-I      intronic chr10:98468806(-) A-I      intronic chr10:98467218(-) A-I      intronic chr10:98390514(-) A-I      intronic chr10:98413517(-) A-I      intronic chr10:98400498(-) A-I      intronic chr10:98462173(-) A-I      intronic chr10:98413518(-) A-I      intronic chr10:98467116(-) A-I      intronic chr10:98431713(-) A-I      intronic chr10:98431700(-) A-I      intronic chr10:98473686(-) A-I      intronic chr10:98468842(-) A-I      intronic chr10:98412190(-) A-I      intronic chr10:98468766(-) A-I      intronic chr10:98468220(-) A-I      intronic chr10:98468197(-) A-I      intronic chr10:98467152(-) A-I      intronic chr10:98413105(-) A-I      intronic chr10:98361752(-) A-I      intronic chr10:98365675(-) A-I      intronic chr10:98413080(-) A-I      intronic chr10:98465855(-) A-I      intronic chr10:98461995(-) A-I      intronic chr10:98413038(-) A-I      intronic chr10:98439209(-) A-I      intronic chr10:98464309(-) A-I      intronic chr10:98465831(-) A-I      intronic chr10:98365741(-) A-I      intronic chr10:98384363(-) A-I      intronic chr10:98361891(-) A-I      intronic chr10:98465830(-) A-I      intronic chr10:98361912(-) A-I      intronic chr10:98462128(-) A-I      intronic chr10:98462144(-) A-I      intronic chr10:98438080(-) A-I      intronic chr10:98462757(-) A-I      intronic chr10:98361913(-) A-I      intronic chr10:98395479(-) A-I      intronic chr10:98364647(-) A-I      intronic chr10:98395493(-) A-I      intronic chr10:98364777(-) A-I      intronic chr10:98465825(-) A-I      intronic chr10:98412996(-) A-I      intronic chr10:98397181(-) A-I      intronic chr10:98468716(-) A-I      intronic chr10:98389424(-) A-I      intronic chr10:98465845(-) A-I      intronic chr10:98467220(-) A-I      intronic chr10:98413342(-) A-I      intronic chr10:98415178(-) A-I      intronic chr10:98467178(-) A-I      intronic chr10:98468662(-) A-I      intronic chr10:98412959(-) A-I      intronic chr10:98385784(-) A-I      intronic chr10:98465508(-) A-I      intronic chr10:98462001(-) A-I      intronic chr10:98413412(-) A-I      intronic chr10:98465513(-) A-I      intronic chr10:98413049(-) A-I      intronic chr10:98468867(-) A-I      intronic chr10:98361765(-) A-I      intronic chr10:98384339(-) A-I      intronic chr10:98389543(-) A-I      intronic chr10:98462811(-) A-I      intronic chr10:98468705(-) A-I      intronic chr10:98454300(-) A-I      intronic chr10:98464353(-) A-I      intronic chr10:98413413(-) A-I      intronic chr10:98462230(-) A-I      intronic chr10:98457283(-) A-I      intronic chr10:98360996(-) A-I      intronic chr10:98412979(-) A-I      intronic chr10:98467245(-) A-I      intronic chr10:98464312(-) A-I      intronic chr10:98462174(-) A-I      intronic chr10:98465628(-) A-I      intronic chr10:98373029(-) A-I      intronic chr10:98364755(-) A-I      intronic chr10:98462134(-) A-I      intronic chr10:98465536(-) A-I      intronic chr10:98438170(-) A-I      intronic chr10:98361726(-) A-I      intronic chr10:98467329(-) A-I      intronic chr10:98413418(-) A-I      intronic chr10:98457300(-) A-I      intronic chr10:98415026(-) A-I      intronic chr10:98462731(-) A-I      intronic chr10:98437885(-) A-I      intronic chr10:98450304(-) A-I      intronic chr10:98462090(-) A-I      intronic chr10:98468722(-) A-I      intronic chr10:98454406(-) A-I      intronic chr10:98450220(-) A-I      intronic chr10:98464367(-) A-I      intronic chr10:98464230(-) A-I      intronic chr10:98467187(-) A-I      intronic chr10:98464240(-) A-I      intronic chr10:98364013(-) A-I      intronic chr10:98464442(-) A-I      intronic chr10:98464388(-) A-I      intronic chr10:98413373(-) A-I      intronic chr10:98365719(-) A-I      intronic chr10:98365629(-) A-I      intronic chr10:98467203(-) A-I      intronic chr10:98365791(-) A-I      intronic chr10:98464470(-) A-I      intronic chr10:98454451(-) A-I      intronic chr10:98467188(-) A-I      intronic chr10:98468807(-) A-I      intronic chr10:98365717(-) A-I      intronic chr10:98465442(-) A-I      intronic chr10:98467223(-) A-I      intronic chr10:98384413(-) A-I      intronic chr10:98467115(-) A-I      intronic chr10:98361868(-) A-I      intronic chr10:98464218(-) A-I      intronic chr10:98462088(-) A-I      intronic chr10:98415142(-) A-I      intronic chr10:98415043(-) A-I      intronic chr10:98438110(-) A-I      intronic chr10:98361835(-) A-I      intronic chr10:98468837(-) A-I      intronic chr10:98431673(-) A-I      intronic chr10:98423117(-) A-I      intronic chr10:98462248(-) A-I      intronic chr10:98413050(-) A-I      intronic chr10:98365693(-) A-I      intronic chr10:98468768(-) A-I      intronic chr10:98457410(-) A-I      intronic chr10:98365729(-) A-I      intronic chr10:98462247(-) A-I      intronic chr10:98431790(-) A-I      intronic chr10:98437859(-) A-I      intronic chr10:98457455(-) A-I      intronic chr10:98454492(-) A-I      intronic chr10:98365732(-) A-I      intronic chr10:98413079(-) A-I      intronic chr10:98365826(-) A-I      intronic chr10:98450240(-) A-I      intronic chr10:98439160(-) A-I      intronic chr10:98364894(-) A-I      intronic chr10:98413382(-) A-I      intronic chr10:98462854(-) A-I      intronic chr10:98415182(-) A-I      intronic chr10:98364901(-) A-I      intronic chr10:98467147(-) A-I      intronic chr10:98464389(-) A-I      intronic chr10:98413449(-) A-I      intronic chr10:98360986(-) A-I      intronic chr10:98454414(-) A-I      intronic chr10:98361805(-) A-I      intronic chr10:98469301(-) A-I      intronic chr10:98467723(-) A-I      intronic chr10:98469253(-) A-I      intronic chr10:98467631(-) A-I      intronic chr10:98467595(-) A-I      intronic chr10:98465412(-) A-I      intronic chr10:98415058(-) A-I      intronic chr10:98468778(-) A-I      intronic chr10:98462947(-) A-I      intronic chr10:98457713(-) A-I      intronic chr10:98469230(-) A-I      intronic chr10:98365608(-) A-I      intronic chr10:98449325(-) A-I      intronic chr10:98467763(-) A-I      intronic chr10:98361821(-) A-I      intronic chr10:98412970(-) A-I      intronic chr10:98469297(-) A-I      intronic chr10:98469298(-) A-I      intronic chr10:98469207(-) A-I      intronic chr10:98469222(-) A-I      intronic chr10:98469203(-) A-I      intronic chr10:98469227(-) A-I      intronic chr10:98467727(-) A-I      intronic chr10:98462741(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PIK3AP1	chr10:98467727(-) A-I intron -    22327324 chr10:98360996(-) A-G intron -    22484847 chr10:98365791(-) A-G intron -    22484847 chr10:98365826(-) A-G intron -    22484847 chr10:98402062(-) T-C intron -    22484847 chr10:98402089(-) T-C intron -    22484847 chr10:98412907(-) A-G intron -    22484847 chr10:98412912(-) A-G intron -    22484847 chr10:98462798(-) A-G intron -    22484847 chr10:98462924(-) A-G intron -    22484847 chr10:98464292(-) A-G intron -    22484847 chr10:98464309(-) A-G intron -    22484847 chr10:98464353(-) A-G intron -    22484847 chr10:98464363(-) A-G intron -    22484847 chr10:98467115(-) A-G intron -    22484847 chr10:98467116(-) A-G intron -    22484847 chr10:98467147(-) A-G intron -    22484847 chr10:98467178(-) A-G intron -    22484847 chr10:98467210(-) A-G intron -    22484847 chr10:98467723(-) A-G intron -    22484847 chr10:98467763(-) A-G intron -    22484847 chr10:98469207(-) A-G intron -    22484847 chr10:98469222(-) A-G intron -    22484847 chr10:98469297(-) A-G intron -    22484847 chr10:98469298(-) A-G intron -    22484847 chr10:98469301(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIK3AP1	chr10:98355076-98355077(-) m6A 3'UTR       24981863//27773535 chr10:98355106-98355107(-) m6A 3'UTR       24981863//28052920//27773535 chr10:98355142-98355143(-) m6A 3'UTR       24981863//28052920//27773535 chr10:98355294-98355295(-) m6A 3'UTR       24209618//24981863//28052920//27773535//27371828//22608085 chr10:98355302-98355303(-) m6A 3'UTR       24209618//24981863//28052920//27773535//27371828//22608085 chr10:98355318-98355319(-) m6A 3'UTR       24209618//24981863//28052920//27773535//27371828//22608085 chr10:98355374-98355375(-) m6A CDS//exon       24209618//24981863//27773535//27371828 chr10:98362071-98362072(-) m6A CDS//exon       24209618//27773535//27371828 chr10:98362094-98362095(-) m6A CDS//exon       24209618//27773535 chr10:98363516-98363517(-) m6A exon//intron       27773535 chr10:98363530-98363531(-) m6A exon//intron       27773535 chr10:98363584-98363585(-) m6A exon//intron       27773535 chr10:98369492-98369493(-) m6A CDS//exon       24981863//27773535//27371828 chr10:98369500-98369501(-) m6A CDS//exon       24981863//27773535//27371828 chr10:98376398-98376399(-) m6A CDS//exon       27773535//27371828 chr10:98376429-98376430(-) m6A CDS//exon       27773535//27371828 chr10:98376445-98376446(-) m6A CDS//exon       27773535//27371828 chr10:98378442-98378443(-) m6A exon//intron       27773535 chr10:98405380-98405381(-) m6A CDS//exon       27773535 chr10:98405408-98405409(-) m6A CDS//exon       27773535 chr10:98408443-98408444(-) m6A CDS//exon       27773535 chr10:98408457-98408458(-) m6A CDS//exon       27773535 chr10:98469583-98469584(-) m6A CDS       27371828 chr10:98469668-98469669(-) m6A CDS       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PIK3AP1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PIK3AP1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.