Basic Information:

  VIRBase ID:  

VHID00515433

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TOP1MT:  NM_001258447     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TOP1MT
miRBase Accession/Entrez ID	MIMAT0001581	116447
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TOP1MT	chr8:144393406(-) A-I      intronic chr8:144393394(-) A-I      intronic chr8:144415474(-) A-I      intronic chr8:144393214(-) A-I      intronic chr8:144393342(-) A-I      intronic chr8:144393131(-) A-I      intronic chr8:144393271(-) A-I      intronic chr8:144393728(-) A-I      intronic chr8:144402637(-) A-I      intronic chr8:144393334(-) A-I      intronic chr8:144393864(-) A-I      intronic chr8:144402258(-) A-I      intronic chr8:144393405(-) A-I      intronic chr8:144396652(-) A-I      intronic chr8:144393411(-) A-I      intronic chr8:144393269(-) A-I      intronic chr8:144393804(-) A-I      intronic chr8:144395161(-) A-I      intronic chr8:144395582(-) A-I      intronic chr8:144393661(-) A-I      intronic chr8:144396597(-) A-I      intronic chr8:144402061(-) A-I      intronic chr8:144395186(-) A-I      intronic chr8:144393753(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TOP1MT	chr8:144393313(-) T-A intron -    22484847 chr8:144393753(-) A-G intron -    22484847 chr8:144393796(-) T-C intron -    22484847 chr8:144393816(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TOP1MT	chr8:144391592-144391593(-) m6A 3'UTR//exon       27773535//27773536 chr8:144391623-144391624(-) m6A CDS//exon       27773535//27773536 chr8:144391669-144391670(-) m6A CDS//exon       27773535//27773536 chr8:144392258-144392259(-) m6A CDS//exon       24209618//27773535//27371828//27773536 chr8:144392300-144392301(-) m6A CDS//exon       24284625//24209618//25456834//27773535//27371828//27773536 chr8:144392312-144392313(-) m6A CDS//exon       24284625//24209618//25456834//27773535//27371828//27773536 chr8:144392373-144392374(-) m1A CDS//exon       26863196 chr8:144392491-144392492(-) m6A exon//intron       24284625//25456834//27773536 chr8:144398289-144398290(-) m6A 3'UTR//CDS       24209618//27773535//27773536 chr8:144399943-144399944(-) m6A 3'UTR//CDS       27773535//27773536 chr8:144399993-144399994(-) m6A 3'UTR//CDS       27773535//27773536 chr8:144400023-144400024(-) m6A 3'UTR//CDS//intron       27773536 chr8:144400218-144400219(-) m6A 3'UTR//CDS       27773535 chr8:144400224-144400225(-) m6A 3'UTR//CDS       27773535 chr8:144400245-144400246(-) m6A 3'UTR//CDS       27773535 chr8:144403410-144403411(-) m6A 3'UTR//CDS       27773535 chr8:144406201-144406202(-) m6A 3'UTR//CDS       - chr8:144406284-144406285(-) m6A 3'UTR//CDS       27371828 chr8:144406305-144406306(-) m6A 3'UTR//CDS       27371828 chr8:144406673-144406674(-) m6A 3'UTR//CDS       27371828 chr8:144406697-144406698(-) m6A 3'UTR//CDS       24209618 chr8:144406713-144406714(-) m6A 3'UTR//CDS       24209618 chr8:144406796-144406797(-) m6A 3'UTR//CDS       24284625//24209618 chr8:144407679-144407680(-) m6A 3'UTR//CDS//intron       24209618//24981863//27773535//27371828//27773536 chr8:144408434-144408435(-) m6A 3'UTR//CDS       24209618//24981863//27773535//27371828//27773536 chr8:144408473-144408474(-) m6A 3'UTR//CDS       24209618//24981863//27773535//27371828//27773536 chr8:144409503-144409504(-) m6A 3'UTR//intron       24209618//24981863//27773535//27371828 chr8:144409584-144409585(-) m6A 3'UTR//intron       27773535 chr8:144409590-144409591(-) m6A 3'UTR//intron       27773535 chr8:144410443-144410444(-) m6A 3'UTR//intron       24209618 chr8:144411541-144411542(-) m6A CDS       24209618//27773535 chr8:144413469-144413470(-) m6A 5'UTR//CDS       24209618//27773535//27371828//27773536 chr8:144413962-144413963(-) m6A 5'UTR//intron       24981863//27773535//27371828//27773536 chr8:144416390-144416391(-) m6A 5'UTR//intron       - chr8:144442075-144442076(-) m6A 5'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TOP1MT	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TOP1MT

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.