Basic Information:

  VIRBase ID:  

VHID00515297

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          MBD6:  NM_052897     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	MBD6
miRBase Accession/Entrez ID	MIMAT0001581	114785
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MBD6	chr12:57916781-57916782(+) m6A 5'UTR//intron       24284625 chr12:57917842-57917843(+) m6A 5'UTR//exon//intron       - chr12:57917847-57917848(+) m6A 5'UTR//exon//intron       - chr12:57917899-57917900(+) m6A 5'UTR//intron       - chr12:57919251-57919252(+) m6A CDS//intron       24981863 chr12:57919520-57919521(+) m6A CDS//intron       24284625//24209618//24981863 chr12:57919854-57919855(+) m6A CDS//intron       24284625 chr12:57919897-57919898(+) m6A CDS//intron       24284625 chr12:57920001-57920002(+) m6A CDS//intron       24284625 chr12:57920140-57920141(+) m6A CDS       - chr12:57921991-57921992(+) m6A CDS       24284625 chr12:57922114-57922115(+) m6A CDS       24284625//24981863 chr12:57922205-57922206(+) m6A CDS       - chr12:57922225-57922226(+) m6A CDS       - chr12:57922250-57922251(+) m6A CDS       - chr12:57922335-57922336(+) m6A CDS       - chr12:57922739-57922740(+) m6A CDS       24284625 chr12:57922760-57922761(+) m6A CDS       24284625 chr12:57922773-57922774(+) m6A CDS       24284625 chr12:57922991-57922992(+) m6A CDS       24284625 chr12:57923004-57923005(+) m6A CDS       24284625 chr12:57923105-57923106(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr12:57923264-57923265(+) Y 3'UTR//intron       26075521 chr12:57923413-57923414(+) m6A 3'UTR//intron       27773535 chr12:57923569-57923570(+) m6A 3'UTR//intron       - chr12:57923820-57923821(+) m6A 3'UTR       27773535 chr12:57923825-57923826(+) m6A 3'UTR       27773535 chr12:57923891-57923892(+) m6A 3'UTR       27773535 chr12:57923925-57923926(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MBD6	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: MBD6

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.