Basic Information:

  VIRBase ID:  

VHID00515290

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CYGB:  NM_134268     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CYGB
miRBase Accession/Entrez ID	MIMAT0001581	114757
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HGB//STAP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CYGB	chr17:74528654(-) A-I      intronic chr17:74528697(-) A-I      intronic chr17:74528716(-) A-I      intronic chr17:74528674(-) A-I      intronic chr17:74528668(-) A-I      intronic chr17:74529657(-) A-I      intronic chr17:74529634(-) A-I      intronic chr17:74529622(-) A-I      intronic chr17:74529589(-) A-I      intronic chr17:74529585(-) A-I      intronic chr17:74529556(-) A-I      intronic chr17:74529550(-) A-I      intronic chr17:74528706(-) A-I      intronic chr17:74530319(-) A-I      intronic chr17:74530098(-) A-I      intronic chr17:74530093(-) A-I      intronic chr17:74528681(-) A-I      intronic chr17:74528682(-) A-I      intronic chr17:74528699(-) A-I      intronic chr17:74529991(-) A-I      intronic chr17:74529997(-) A-I      intronic chr17:74530084(-) A-I      intronic chr17:74530542(-) A-I      intronic chr17:74528738(-) A-I      intronic chr17:74530540(-) A-I      intronic chr17:74530425(-) A-I      intronic chr17:74530393(-) A-I      intronic chr17:74529989(-) A-I      intronic chr17:74529932(-) A-I      intronic chr17:74529761(-) A-I      intronic chr17:74529683(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CYGB	chr17:74523474-74523475(-) m6A 3'UTR       27773535 chr17:74523924-74523925(-) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CYGB	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CYGB

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//RNAHybrid
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.