Basic Information:

  VIRBase ID:  

VHID00515250

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          GLCCI1:  NM_138426     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	GLCCI1
miRBase Accession/Entrez ID	MIMAT0001581	113263
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	FAM117C//GCTR//GIG18//TSSN1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GLCCI1	chr7:8056044(+) A-I      intronic chr7:8055988(+) A-I      intronic chr7:8055984(+) A-I      intronic chr7:8055978(+) A-I      intronic chr7:8055952(+) A-I      intronic chr7:8053905(+) A-I      intronic chr7:8048019(+) A-I      intronic chr7:8038057(+) A-I      intronic chr7:8027282(+) A-I      intronic chr7:8027269(+) A-I      intronic chr7:8027264(+) A-I      intronic chr7:8019705(+) A-I      intronic chr7:8081433(+) A-I      intronic chr7:8016405(+) A-I      intronic chr7:8016393(+) A-I      intronic chr7:8020672(+) A-I      intronic chr7:8020643(+) A-I      intronic chr7:8079493(+) A-I      intronic chr7:8079507(+) A-I      intronic chr7:8081498(+) A-I      intronic chr7:8100937(+) A-I      intronic chr7:8082194(+) A-I      intronic chr7:8084269(+) A-I      intronic chr7:8082275(+) A-I      intronic chr7:8102894(+) A-I      intronic chr7:8081362(+) A-I      intronic chr7:8081333(+) A-I      intronic chr7:8084153(+) A-I      intronic chr7:8084156(+) A-I      intronic chr7:8084158(+) A-I      intronic chr7:8084270(+) A-I      intronic chr7:8107808(+) A-I      intronic chr7:8107859(+) A-I      intronic chr7:8107873(+) A-I      intronic chr7:8107940(+) A-I      intronic chr7:8081278(+) A-I      intronic chr7:8080012(+) A-I      intronic chr7:8081370(+) A-I      intronic chr7:8102965(+) A-I      intronic chr7:8066932(+) A-I      intronic chr7:8037926(+) A-I      intronic chr7:8107860(+) A-I      intronic chr7:8080085(+) A-I      intronic chr7:8048053(+) A-I      intronic chr7:8079934(+) A-I      intronic chr7:8037951(+) A-I      intronic chr7:8050709(+) A-I      intronic chr7:8079977(+) A-I      intronic chr7:8053694(+) A-I      intronic chr7:8082185(+) A-I      intronic chr7:8015963(+) A-I      intronic chr7:8015990(+) A-I      intronic chr7:8019617(+) A-I      intronic chr7:8079914(+) A-I      intronic chr7:8102868(+) A-I      intronic chr7:8082187(+) A-I      intronic chr7:8053719(+) A-I      intronic chr7:8019714(+) A-I      intronic chr7:8081422(+) A-I      intronic chr7:8015989(+) A-I      intronic chr7:8079572(+) A-I      intronic chr7:8082217(+) A-I      intronic chr7:8027244(+) A-I      intronic chr7:8035007(+) A-I      intronic chr7:8082247(+) A-I      intronic chr7:8107784(+) A-I      intronic chr7:8081346(+) A-I      intronic chr7:8080035(+) A-I      intronic chr7:8104621(+) A-I      intronic chr7:8066862(+) A-I      intronic chr7:8023771(+) A-I      intronic chr7:8103350(+) A-I      intronic chr7:8079577(+) A-I      intronic chr7:8016423(+) A-I      intronic chr7:8103487(+) A-I      intronic chr7:8107724(+) A-I      intronic chr7:8081411(+) A-I      intronic chr7:8107771(+) A-I      intronic chr7:8107769(+) A-I      intronic chr7:8039118(+) A-I      intronic chr7:8083837(+) A-I      intronic chr7:8081412(+) A-I      intronic chr7:8102985(+) A-I      intronic chr7:8081431(+) A-I      intronic chr7:8081499(+) A-I      intronic chr7:8053720(+) A-I      intronic chr7:8079873(+) A-I      intronic chr7:8081378(+) A-I      intronic chr7:8037912(+) A-I      intronic chr7:8053681(+) A-I      intronic chr7:8081249(+) A-I      intronic chr7:8016396(+) A-I      intronic chr7:8047939(+) A-I      intronic chr7:8026049(+) A-I      intronic chr7:8027280(+) A-I      intronic chr7:8103461(+) A-I      intronic chr7:8053759(+) A-I      intronic chr7:8095699(+) A-I      intronic chr7:8050615(+) A-I      intronic chr7:8016305(+) A-I      intronic chr7:8107793(+) A-I      intronic chr7:8101397(+) A-I      intronic chr7:8107727(+) A-I      intronic chr7:8053676(+) A-I      intronic chr7:8081350(+) A-I      intronic chr7:8055946(+) A-I      intronic chr7:8083849(+) A-I      intronic chr7:8027299(+) A-I      intronic chr7:8107823(+) A-I      intronic chr7:8107857(+) A-I      intronic chr7:8107869(+) A-I      intronic chr7:8081321(+) A-I      intronic chr7:8037473(+) A-I      intronic chr7:8027275(+) A-I      intronic chr7:8103050(+) A-I      intronic chr7:8100749(+) A-I      intronic chr7:8037377(+) A-I      intronic chr7:8027352(+) A-I      intronic chr7:8023766(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GLCCI1	chr7:8020298(+) A-I intron -    22327324 chr7:8020305(+) A-I intron -    22327324 chr7:8020324(+) A-I intron -    22327324 chr7:8020441(+) A-I intron -    22327324 chr7:8020673(+) A-I intron -    22327324 chr7:8020689(+) A-I intron -    22327324 chr7:8020697(+) A-I intron -    22327324 chr7:8034485(+) A-I intron -    22327324 chr7:8081412(+) A-I intron -    22327324 chr7:8081499(+) A-I intron -    22327324 chr7:8082185(+) A-I intron -    22327324 chr7:8082247(+) A-I intron -    22327324 chr7:8103461(+) A-I intron -    21960545 chr7:8046880(+) T-C intron -    22484847 chr7:8015897(+) A-G intron -    22484847 chr7:8016058(+) T-C intron -    22484847 chr7:8016107(+) T-A intron -    22484847 chr7:8016108(+) C-A intron -    22484847 chr7:8016109(+) T-A intron -    22484847 chr7:8016110(+) C-A intron -    22484847 chr7:8016396(+) A-G intron -    22484847 chr7:8019620(+) A-G intron -    22484847 chr7:8025881(+) T-C intron -    22484847 chr7:8026049(+) A-G intron -    22484847 chr7:8027275(+) A-G intron -    22484847 chr7:8027280(+) A-G intron -    22484847 chr7:8027299(+) A-G intron -    22484847 chr7:8027319(+) A-G intron -    22484847 chr7:8033722(+) A-T intron -    22484847 chr7:8033807(+) T-C intron -    22484847 chr7:8037377(+) A-G intron -    22484847 chr7:8037473(+) A-G intron -    22484847 chr7:8037951(+) A-G intron -    22484847 chr7:8047939(+) A-G intron -    22484847 chr7:8048009(+) A-G intron -    22484847 chr7:8048015(+) A-G intron -    22484847 chr7:8048016(+) A-G intron -    22484847 chr7:8053676(+) A-G intron -    22484847 chr7:8053681(+) A-G intron -    22484847 chr7:8053694(+) A-G intron -    22484847 chr7:8053719(+) A-G intron -    22484847 chr7:8053720(+) A-G intron -    22484847 chr7:8053749(+) A-G intron -    22484847 chr7:8053759(+) A-G intron -    22484847 chr7:8055946(+) A-G intron -    22484847 chr7:8061167(+) T-C intron -    22484847 chr7:8062869(+) T-C intron -    22484847 chr7:8064920(+) A-G intron -    22484847 chr7:8079873(+) A-G intron -    22484847 chr7:8079934(+) A-G intron -    22484847 chr7:8079969(+) A-G intron -    22484847 chr7:8080005(+) A-G intron -    22484847 chr7:8080009(+) A-G intron -    22484847 chr7:8080035(+) A-G intron -    22484847 chr7:8080085(+) A-G intron -    22484847 chr7:8081249(+) A-G intron -    22484847 chr7:8081321(+) A-G intron -    22484847 chr7:8081346(+) A-G intron -    22484847 chr7:8081347(+) A-G intron -    22484847 chr7:8081350(+) A-G intron -    22484847 chr7:8081378(+) A-G intron -    22484847 chr7:8081411(+) A-G intron -    22484847 chr7:8081412(+) A-G intron -    22484847 chr7:8081422(+) A-G intron -    22484847 chr7:8081499(+) A-G intron -    22484847 chr7:8082171(+) A-G intron -    22484847 chr7:8082185(+) A-G intron -    22484847 chr7:8082187(+) A-G intron -    22484847 chr7:8082217(+) A-G intron -    22484847 chr7:8082247(+) A-G intron -    22484847 chr7:8083837(+) A-G intron -    22484847 chr7:8083849(+) A-G intron -    22484847 chr7:8084111(+) A-G intron -    22484847 chr7:8092974(+) G-T intron -    22484847 chr7:8101396(+) A-G intron -    22484847 chr7:8101397(+) A-G intron -    22484847 chr7:8102814(+) T-C intron -    22484847 chr7:8102865(+) C-T intron -    22484847 chr7:8103360(+) C-T intron -    22484847 chr7:8103361(+) A-C intron -    22484847 chr7:8103427(+) A-T intron -    22484847 chr7:8103487(+) A-G intron -    22484847 chr7:8104453(+) A-T intron -    22484847 chr7:8107704(+) A-G intron -    22484847 chr7:8107724(+) A-G intron -    22484847 chr7:8107769(+) A-G intron -    22484847 chr7:8107771(+) A-G intron -    22484847 chr7:8107777(+) A-G intron -    22484847 chr7:8107793(+) A-G intron -    22484847 chr7:8107857(+) A-G intron -    22484847 chr7:8107860(+) A-G intron -    22484847 chr7:8107912(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GLCCI1	chr7:8008493-8008494(+) m6A 5'UTR       - chr7:8008842-8008843(+) m6A 5'UTR       - chr7:8010106-8010107(+) m6A exon//intron       - chr7:8021692-8021693(+) m6A intron       22608085 chr7:8021697-8021698(+) m6A intron       22608085 chr7:8021704-8021705(+) m6A intron       22608085 chr7:8021772-8021773(+) m6A intron       22608085 chr7:8021805-8021806(+) m6A intron       22608085 chr7:8095097-8095098(+) Y CDS//exon       26075521 chr7:8125869-8125870(+) m6A CDS//exon//intron       24284625//24209618//22608085 chr7:8125915-8125916(+) m6A CDS//exon//intron       24284625//24209618//24981863//22608085 chr7:8125959-8125960(+) m6A CDS//exon//intron       24284625//24209618//24981863//22608085 chr7:8126119-8126120(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126133-8126134(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126151-8126152(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126211-8126212(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126223-8126224(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126242-8126243(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126251-8126252(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126300-8126301(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr7:8126323-8126324(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr7:8126398-8126399(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GLCCI1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: GLCCI1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.