Basic Information:

  VIRBase ID:  

VHID00515095

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ARRDC1:  NM_001317968     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ARRDC1
miRBase Accession/Entrez ID	MIMAT0001581	92714
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARRDC1	chr9:140505900(+) A-I      intronic chr9:140505952(+) A-I      ncRNA chr9:140505945(+) A-I      ncRNA chr9:140504480(+) A-I      intronic chr9:140504473(+) A-I      intronic chr9:140504402(+) A-I      intronic chr9:140505868(+) A-I      intronic chr9:140505823(+) A-I      intronic chr9:140505822(+) A-I      intronic chr9:140505786(+) A-I      intronic chr9:140505772(+) A-I      intronic chr9:140505752(+) A-I      intronic chr9:140505746(+) A-I      intronic chr9:140505745(+) A-I      intronic chr9:140503767(+) A-I      intronic chr9:140505727(+) A-I      intronic chr9:140504989(+) A-I      intronic chr9:140504987(+) A-I      intronic chr9:140504977(+) A-I      intronic chr9:140505845(+) A-I      intronic chr9:140504239(+) A-I      intronic chr9:140505824(+) A-I      intronic chr9:140505805(+) A-I      intronic chr9:140504974(+) A-I      intronic chr9:140504965(+) A-I      intronic chr9:140504948(+) A-I      intronic chr9:140504896(+) A-I      intronic chr9:140505825(+) A-I      intronic chr9:140504927(+) A-I      intronic chr9:140504873(+) A-I      intronic chr9:140504872(+) A-I      intronic chr9:140503816(+) A-I      intronic chr9:140504465(+) A-I      intronic chr9:140504252(+) A-I      intronic chr9:140504175(+) A-I      intronic chr9:140504094(+) A-I      intronic chr9:140504383(+) A-I      intronic chr9:140504928(+) A-I      intronic chr9:140504405(+) A-I      intronic chr9:140504217(+) A-I      intronic chr9:140504116(+) A-I      intronic chr9:140504540(+) A-I      intronic chr9:140504213(+) A-I      intronic chr9:140504407(+) A-I      intronic chr9:140504240(+) A-I      intronic chr9:140504212(+) A-I      intronic chr9:140504441(+) A-I      intronic chr9:140502454(+) A-I      intronic chr9:140504867(+) A-I      intronic chr9:140504917(+) A-I      intronic chr9:140505880(+) A-I      intronic chr9:140506052(+) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ARRDC1	chr9:140504240(+) A-I intron -    15258596 chr9:140504395(+) A-I intron -    15258596 chr9:140504441(+) A-I intron -    15258596 chr9:140504465(+) A-I intron -    15258596 chr9:140504917(+) A-I intron -    15258596 chr9:140505880(+) A-I intron -    22327324 chr9:140505890(+) A-I intron -    22327324 chr9:140505944(+) A-I intron -    22327324 chr9:140504867(+) A-G intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARRDC1	chr9:140506044-140506045(+) m6A exon//intron       25456834 chr9:140506055-140506056(+) m6A exon//intron       24284625//25456834 chr9:140506099-140506100(+) m6A exon//intron       24284625//25456834 chr9:140506169-140506170(+) m6A exon//intron       24284625 chr9:140506315-140506316(+) m6A exon//intron       24284625//27371828 chr9:140506439-140506440(+) m6A exon//intron       25456834//27371828 chr9:140506607-140506608(+) m6A exon//intron       24284625//24209618//25456834//24981863//27371828//22608085 chr9:140506651-140506652(+) m6A exon//intron       24284625//24209618//25456834//24981863//27371828//22608085 chr9:140506666-140506667(+) m6A exon//intron       24284625//24209618//25456834//24981863//27371828//22608085 chr9:140506695-140506696(+) m6A exon//intron       24284625//24209618//25456834//24981863//22608085 chr9:140506758-140506759(+) m6A exon//intron       24284625//25456834//24981863//27371828//22608085 chr9:140506849-140506850(+) m6A exon//intron       24284625//25456834//27371828//22608085 chr9:140507176-140507177(+) m6A exon//intron       24284625//27371828//27773536 chr9:140507238-140507239(+) m6A exon//intron       24284625//27371828//27773536 chr9:140507452-140507453(+) m6A CDS//exon       25456834//27371828 chr9:140507710-140507711(+) m6A 3'UTR//intron       24284625//27773535 chr9:140507795-140507796(+) m6A 3'UTR//exon//intron       24284625//25456834//27371828//22608085 chr9:140507803-140507804(+) m6A 3'UTR//exon//intron       24284625//25456834//27371828//22608085 chr9:140507880-140507881(+) m6A 3'UTR//exon//intron       24284625//25456834//27371828//27773536//22608085 chr9:140508195-140508196(+) m6A CDS//exon       24284625//27371828//27773536 chr9:140508201-140508202(+) m6A CDS//exon       24284625//27371828//27773536 chr9:140508213-140508214(+) m6A CDS//exon       24284625//27773536 chr9:140508619-140508620(+) m6A CDS//exon       27371828//27773536 chr9:140508634-140508635(+) m6A CDS//exon       27371828//27773536 chr9:140508792-140508793(+) m6A CDS//exon       27371828//27773536 chr9:140509074-140509075(+) m6A CDS//exon       27371828 chr9:140509203-140509204(+) m6A CDS//exon       24284625//27371828//27773536 chr9:140509211-140509212(+) Y CDS//exon       26075521 chr9:140509505-140509506(+) m6A exon//intron       24284625//27371828 chr9:140509565-140509566(+) m6A CDS//exon       24284625//27371828//27773536 chr9:140509633-140509634(+) m6A 3'UTR//exon       24284625//25456834//27371828//27773536 chr9:140509689-140509690(+) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//27773536 chr9:140509768-140509769(+) m6A 3'UTR//exon       24981863//27773536 chr9:140509778-140509779(+) m6A 3'UTR//exon       24981863//27773536 chr9:140509796-140509797(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ARRDC1	Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ARRDC1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.