Basic Information:

  VIRBase ID:  

VHID00515092

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          FAM114A1:  NM_001350635     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	FAM114A1
miRBase Accession/Entrez ID	MIMAT0001581	92689
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	Noxp20

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM114A1	chr4:38886696(+) A-I      intronic chr4:38886689(+) A-I      intronic chr4:38937897(+) A-I      intronic chr4:38936670(+) A-I      intronic chr4:38936665(+) A-I      intronic chr4:38923702(+) A-I      intronic chr4:38923662(+) A-I      intronic chr4:38923637(+) A-I      intronic chr4:38923627(+) A-I      intronic chr4:38923143(+) A-I      intronic chr4:38923079(+) A-I      intronic chr4:38922991(+) A-I      intronic chr4:38921749(+) A-I      intronic chr4:38921734(+) A-I      intronic chr4:38921730(+) A-I      intronic chr4:38921719(+) A-I      intronic chr4:38920695(+) A-I      intronic chr4:38918860(+) A-I      intronic chr4:38916152(+) A-I      intronic chr4:38916147(+) A-I      intronic chr4:38916072(+) A-I      intronic chr4:38916028(+) A-I      intronic chr4:38916027(+) A-I      intronic chr4:38916025(+) A-I      intronic chr4:38916024(+) A-I      intronic chr4:38915966(+) A-I      intronic chr4:38915610(+) A-I      intronic chr4:38915606(+) A-I      intronic chr4:38915601(+) A-I      intronic chr4:38915600(+) A-I      intronic chr4:38915245(+) A-I      intronic chr4:38915233(+) A-I      intronic chr4:38915232(+) A-I      intronic chr4:38915164(+) A-I      intronic chr4:38915075(+) A-I      intronic chr4:38915041(+) A-I      intronic chr4:38915039(+) A-I      intronic chr4:38914207(+) A-I      intronic chr4:38913679(+) A-I      intronic chr4:38913665(+) A-I      intronic chr4:38913563(+) A-I      intronic chr4:38911847(+) A-I      intronic chr4:38911820(+) A-I      intronic chr4:38911801(+) A-I      intronic chr4:38911698(+) A-I      intronic chr4:38911678(+) A-I      intronic chr4:38911676(+) A-I      intronic chr4:38906816(+) A-I      intronic chr4:38906808(+) A-I      intronic chr4:38890064(+) A-I      intronic chr4:38890063(+) A-I      intronic chr4:38890059(+) A-I      intronic chr4:38889910(+) A-I      intronic chr4:38889867(+) A-I      intronic chr4:38888469(+) A-I      intronic chr4:38888455(+) A-I      intronic chr4:38888012(+) A-I      intronic chr4:38887975(+) A-I      intronic chr4:38887030(+) A-I      intronic chr4:38886955(+) A-I      intronic chr4:38886839(+) A-I      intronic chr4:38886725(+) A-I      intronic chr4:38886713(+) A-I      intronic chr4:38895338(+) A-I      intronic chr4:38896193(+) A-I      intronic chr4:38896208(+) A-I      intronic chr4:38896637(+) A-I      intronic chr4:38896642(+) A-I      intronic chr4:38896673(+) A-I      intronic chr4:38896677(+) A-I      intronic chr4:38896678(+) A-I      intronic chr4:38898289(+) A-I      intronic chr4:38923028(+) A-I      intronic chr4:38944617(+) A-I      intronic chr4:38944611(+) A-I      intronic chr4:38944603(+) A-I      intronic chr4:38923020(+) A-I      intronic chr4:38923018(+) A-I      intronic chr4:38923013(+) A-I      intronic chr4:38923009(+) A-I      intronic chr4:38922965(+) A-I      intronic chr4:38921748(+) A-I      intronic chr4:38921709(+) A-I      intronic chr4:38921707(+) A-I      intronic chr4:38913756(+) A-I      intronic chr4:38913744(+) A-I      intronic chr4:38911739(+) A-I      intronic chr4:38921723(+) A-I      intronic chr4:38913725(+) A-I      intronic chr4:38913704(+) A-I      intronic chr4:38913587(+) A-I      intronic chr4:38913586(+) A-I      intronic chr4:38913583(+) A-I      intronic chr4:38913582(+) A-I      intronic chr4:38911812(+) A-I      intronic chr4:38911693(+) A-I      intronic chr4:38911677(+) A-I      intronic chr4:38911658(+) A-I      intronic chr4:38944749(+) A-I      intronic chr4:38944708(+) A-I      intronic chr4:38944699(+) A-I      intronic chr4:38941732(+) A-I      intronic chr4:38941692(+) A-I      intronic chr4:38941614(+) A-I      intronic chr4:38939621(+) A-I      intronic chr4:38939619(+) A-I      intronic chr4:38945890(+) A-I      3'UTR chr4:38945882(+) A-I      3'UTR chr4:38945855(+) A-I      3'UTR chr4:38945876(+) A-I      3'UTR chr4:38885793(+) A-I      intronic chr4:38923063(+) A-I      intronic chr4:38944667(+) A-I      intronic chr4:38937853(+) A-I      intronic chr4:38915132(+) A-I      intronic chr4:38923760(+) A-I      intronic chr4:38916066(+) A-I      intronic chr4:38911668(+) A-I      intronic chr4:38921597(+) A-I      intronic chr4:38886801(+) A-I      intronic chr4:38923117(+) A-I      intronic chr4:38915246(+) A-I      intronic chr4:38915494(+) A-I      intronic chr4:38923118(+) A-I      intronic chr4:38916089(+) A-I      intronic chr4:38915051(+) A-I      intronic chr4:38920544(+) A-I      intronic chr4:38945845(+) A-I      3'UTR chr4:38920318(+) A-I      intronic chr4:38915076(+) A-I      intronic chr4:38915044(+) A-I      intronic chr4:38915070(+) A-I      intronic chr4:38920653(+) A-I      intronic chr4:38944693(+) A-I      intronic chr4:38915263(+) A-I      intronic chr4:38913717(+) A-I      intronic chr4:38944626(+) A-I      intronic chr4:38923157(+) A-I      intronic chr4:38915195(+) A-I      intronic chr4:38891867(+) A-I      intronic chr4:38923135(+) A-I      intronic chr4:38913538(+) A-I      intronic chr4:38915144(+) A-I      intronic chr4:38911843(+) A-I      intronic chr4:38922940(+) A-I      intronic chr4:38915154(+) A-I      intronic chr4:38913647(+) A-I      intronic chr4:38913656(+) A-I      intronic chr4:38885830(+) A-I      intronic chr4:38911740(+) A-I      intronic chr4:38918654(+) A-I      intronic chr4:38889905(+) A-I      intronic chr4:38915485(+) A-I      intronic chr4:38881524(+) A-I      intronic chr4:38915181(+) A-I      intronic chr4:38921778(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FAM114A1	chr4:38886801(+) A-G intron -    22484847 chr4:38914062(+) A-G intron -    22484847 chr4:38922948(+) A-G intron -    22484847 chr4:38922982(+) A-G intron -    22484847 chr4:38923063(+) A-G intron -    22484847 chr4:38923135(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FAM114A1	chr4:38869415-38869416(+) m6A 5'UTR       24284625//24981863 chr4:38879736-38879737(+) m6A CDS//intron       24981863 chr4:38924509-38924510(+) m6A CDS//exon       27773535 chr4:38930944-38930945(+) m6A CDS//exon       24981863//27773535 chr4:38933110-38933111(+) m6A CDS//exon       24981863//27773535 chr4:38933152-38933153(+) m6A CDS//exon       24981863//27773535 chr4:38933186-38933187(+) m6A CDS//exon       24981863//27773535//22575960 chr4:38933198-38933199(+) m6A CDS//exon       24981863//27773535//22575960 chr4:38933218-38933219(+) m6A CDS//exon       24981863//27773535//22575960 chr4:38933224-38933225(+) m6A CDS//exon       24981863//27773535//22575960 chr4:38945151-38945152(+) m6A CDS//exon       24284625 chr4:38945187-38945188(+) m6A 3'UTR//exon       24284625 chr4:38945207-38945208(+) m6A 3'UTR//exon       24284625 chr4:38945272-38945273(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr4:38945286-38945287(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr4:38945309-38945310(+) m6A 3'UTR//exon       24284625//24209618//24981863 chr4:38945376-38945377(+) m6A 3'UTR//exon       24981863 chr4:38946808-38946809(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr4:38946875-38946876(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr4:38946939-38946940(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr4:38947044-38947045(+) m6A 3'UTR       24284625//24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FAM114A1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: FAM114A1

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.