Basic Information:

  VIRBase ID:  

VHID00515033

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          RFT1:  NM_052859     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	RFT1
miRBase Accession/Entrez ID	MIMAT0001581	91869
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDG1N

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RFT1	chr3:53147298(-) A-I      intronic chr3:53147214(-) A-I      intronic chr3:53147211(-) A-I      intronic chr3:53147209(-) A-I      intronic chr3:53147203(-) A-I      intronic chr3:53147196(-) A-I      intronic chr3:53147170(-) A-I      intronic chr3:53146565(-) A-I      intronic chr3:53146553(-) A-I      intronic chr3:53146532(-) A-I      intronic chr3:53146523(-) A-I      intronic chr3:53145386(-) A-I      intronic chr3:53145346(-) A-I      intronic chr3:53145340(-) A-I      intronic chr3:53145336(-) A-I      intronic chr3:53145303(-) A-I      intronic chr3:53143737(-) A-I      intronic chr3:53143654(-) A-I      intronic chr3:53142889(-) A-I      intronic chr3:53142856(-) A-I      intronic chr3:53142613(-) A-I      intronic chr3:53138496(-) A-I      intronic chr3:53138412(-) A-I      intronic chr3:53132742(-) A-I      intronic chr3:53130964(-) A-I      intronic chr3:53130962(-) A-I      intronic chr3:53130642(-) A-I      intronic chr3:53129243(-) A-I      intronic chr3:53129232(-) A-I      intronic chr3:53128234(-) A-I      intronic chr3:53127852(-) A-I      intronic chr3:53162651(-) A-I      intronic chr3:53162288(-) A-I      intronic chr3:53162232(-) A-I      intronic chr3:53162221(-) A-I      intronic chr3:53162214(-) A-I      intronic chr3:53162206(-) A-I      intronic chr3:53162192(-) A-I      intronic chr3:53150694(-) A-I      intronic chr3:53162134(-) A-I      intronic chr3:53162079(-) A-I      intronic chr3:53152034(-) A-I      intronic chr3:53150837(-) A-I      intronic chr3:53150707(-) A-I      intronic chr3:53162142(-) A-I      intronic chr3:53142849(-) A-I      intronic chr3:53142922(-) A-I      intronic chr3:53143678(-) A-I      intronic chr3:53143724(-) A-I      intronic chr3:53153108(-) A-I      intronic chr3:53162773(-) A-I      intronic chr3:53162694(-) A-I      intronic chr3:53122728(-) A-I      3'UTR chr3:53122726(-) A-I      3'UTR chr3:53122625(-) A-I      3'UTR chr3:53130869(-) A-I      intronic chr3:53127753(-) A-I      intronic chr3:53130652(-) A-I      intronic chr3:53152030(-) A-I      intronic chr3:53142516(-) A-I      intronic chr3:53150755(-) A-I      intronic chr3:53130803(-) A-I      intronic chr3:53130663(-) A-I      intronic chr3:53142873(-) A-I      intronic chr3:53142861(-) A-I      intronic chr3:53141425(-) A-I      intronic chr3:53152050(-) A-I      intronic chr3:53153170(-) A-I      intronic chr3:53150756(-) A-I      intronic chr3:53122741(-) A-I      3'UTR chr3:53122848(-) A-I      3'UTR chr3:53122682(-) A-I      3'UTR chr3:53122694(-) A-I      3'UTR chr3:53122695(-) A-I      3'UTR chr3:53122701(-) A-I      3'UTR chr3:53143660(-) A-I      intronic chr3:53143798(-) A-I      intronic chr3:53162205(-) A-I      intronic chr3:53153178(-) A-I      intronic chr3:53142949(-) A-I      intronic chr3:53162777(-) A-I      intronic chr3:53153030(-) A-I      intronic chr3:53146696(-) A-I      intronic chr3:53128182(-) A-I      intronic chr3:53143679(-) A-I      intronic chr3:53129672(-) A-I      intronic chr3:53142642(-) A-I      intronic chr3:53146683(-) A-I      intronic chr3:53142095(-) A-I      intronic chr3:53127819(-) A-I      intronic chr3:53153122(-) A-I      intronic chr3:53141426(-) A-I      intronic chr3:53127826(-) A-I      intronic chr3:53130436(-) A-I      intronic chr3:53128196(-) A-I      intronic chr3:53142501(-) A-I      intronic chr3:53162704(-) A-I      intronic chr3:53142561(-) A-I      intronic chr3:53130849(-) A-I      intronic chr3:53161473(-) A-I      intronic chr3:53130637(-) A-I      intronic chr3:53150506(-) A-I      intronic chr3:53151947(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RFT1	chr3:53130803(-) A-I intron -    22327324 chr3:53122793(-) A-G exon 3'UTR    22484847 chr3:53129277(-) A-G intron -    22484847 chr3:53130577(-) A-G intron -    22484847 chr3:53130637(-) A-G intron -    22484847 chr3:53130652(-) A-G intron -    22484847 chr3:53130663(-) A-G intron -    22484847 chr3:53130849(-) A-G intron -    22484847 chr3:53143581(-) A-G intron -    22484847 chr3:53143660(-) A-G intron -    22484847 chr3:53143676(-) A-G intron -    22484847 chr3:53143679(-) A-G intron -    22484847 chr3:53143798(-) A-G intron -    22484847 chr3:53143818(-) A-G intron -    22484847 chr3:53150506(-) A-G intron -    22484847 chr3:53150755(-) A-G intron -    22484847 chr3:53150756(-) A-G intron -    22484847 chr3:53151947(-) A-G intron -    22484847 chr3:53152030(-) A-G intron -    22484847 chr3:53152050(-) A-G intron -    22484847 chr3:53153030(-) A-G intron -    22484847 chr3:53153061(-) A-G intron -    22484847 chr3:53153122(-) A-G intron -    22484847 chr3:53153178(-) A-G intron -    22484847 chr3:53162186(-) A-G intron -    22484847 chr3:53162205(-) A-G intron -    22484847 chr3:53162231(-) A-G intron -    22484847 chr3:53162777(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RFT1	chr3:53123906-53123907(-) m6A 3'UTR       24284625//25456834 chr3:53123960-53123961(-) m6A 3'UTR       24284625 chr3:53124003-53124004(-) m6A 3'UTR       24284625 chr3:53124241-53124242(-) m6A 3'UTR       24284625 chr3:53124293-53124294(-) m6A 3'UTR       24284625 chr3:53125190-53125191(-) m6A 3'UTR       24981863 chr3:53125348-53125349(-) m6A 3'UTR       27773535 chr3:53125409-53125410(-) m6A 3'UTR       27773535 chr3:53125450-53125451(-) m6A 3'UTR       27773535 chr3:53125478-53125479(-) m6A 3'UTR       27773535 chr3:53125504-53125505(-) m6A 3'UTR       27773535 chr3:53125708-53125709(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr3:53125766-53125767(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:53125856-53125857(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:53125884-53125885(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr3:53125901-53125902(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr3:53125959-53125960(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr3:53125983-53125984(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr3:53126001-53126002(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr3:53126050-53126051(-) m6A CDS       24284625//25456834//24981863//27773535//27773536//22608085 chr3:53126422-53126423(-) m6A CDS       24284625//25456834//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RFT1	Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: RFT1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.