Basic Information:

  VIRBase ID:  

VHID00514980

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ANKRD40:  NM_052855     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ANKRD40
miRBase Accession/Entrez ID	MIMAT0001581	91369
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ANKRD40	chr17:48771274(-) A-I      3'UTR chr17:48784125(-) A-I      intronic chr17:48783098(-) A-I      intronic chr17:48771266(-) A-I      3'UTR chr17:48783512(-) A-I      intronic chr17:48771247(-) A-I      3'UTR chr17:48771248(-) A-I      3'UTR chr17:48783130(-) A-I      intronic chr17:48783189(-) A-I      intronic chr17:48783190(-) A-I      intronic chr17:48783192(-) A-I      intronic chr17:48771249(-) A-I      3'UTR chr17:48784153(-) A-I      intronic chr17:48781764(-) A-I      intronic chr17:48782308(-) A-I      intronic chr17:48782311(-) A-I      intronic chr17:48782326(-) A-I      intronic chr17:48782340(-) A-I      intronic chr17:48782353(-) A-I      intronic chr17:48782363(-) A-I      intronic chr17:48782388(-) A-I      intronic chr17:48783665(-) A-I      intronic chr17:48783681(-) A-I      intronic chr17:48783702(-) A-I      intronic chr17:48783731(-) A-I      intronic chr17:48784018(-) A-I      intronic chr17:48784045(-) A-I      intronic chr17:48783133(-) A-I      intronic chr17:48783128(-) A-I      intronic chr17:48784167(-) A-I      intronic chr17:48783594(-) A-I      intronic chr17:48783611(-) A-I      intronic chr17:48781619(-) A-I      intronic chr17:48783621(-) A-I      intronic chr17:48783647(-) A-I      intronic chr17:48783656(-) A-I      intronic chr17:48783660(-) A-I      intronic chr17:48783662(-) A-I      intronic chr17:48783271(-) A-I      intronic chr17:48783516(-) A-I      intronic chr17:48783556(-) A-I      intronic chr17:48784143(-) A-I      intronic chr17:48783090(-) A-I      intronic chr17:48783089(-) A-I      intronic chr17:48783154(-) A-I      intronic chr17:48783195(-) A-I      intronic chr17:48783186(-) A-I      intronic chr17:48781863(-) A-I      intronic chr17:48781761(-) A-I      intronic chr17:48783238(-) A-I      intronic chr17:48783159(-) A-I      intronic chr17:48779581(-) A-I      intronic chr17:48783127(-) A-I      intronic chr17:48783580(-) A-I      intronic chr17:48783191(-) A-I      intronic chr17:48781631(-) A-I      intronic chr17:48784060(-) A-I      intronic chr17:48783136(-) A-I      intronic chr17:48783050(-) A-I      intronic chr17:48783257(-) A-I      intronic chr17:48783115(-) A-I      intronic chr17:48783150(-) A-I      intronic chr17:48783199(-) A-I      intronic chr17:48783715(-) A-I      intronic chr17:48781837(-) A-I      intronic chr17:48784028(-) A-I      intronic chr17:48783118(-) A-I      intronic chr17:48784183(-) A-I      intronic chr17:48777722(-) A-I      intronic chr17:48783301(-) A-I      intronic chr17:48783262(-) A-I      intronic chr17:48782232(-) A-I      intronic chr17:48783182(-) A-I      intronic chr17:48783293(-) A-I      intronic chr17:48783200(-) A-I      intronic chr17:48782219(-) A-I      intronic chr17:48783056(-) A-I      intronic chr17:48784202(-) A-I      intronic chr17:48781688(-) A-I      intronic chr17:48783240(-) A-I      intronic chr17:48783505(-) A-I      intronic chr17:48783292(-) A-I      intronic chr17:48783225(-) A-I      intronic chr17:48782909(-) A-I      intronic chr17:48783119(-) A-I      intronic chr17:48783124(-) A-I      intronic chr17:48783176(-) A-I      intronic chr17:48784208(-) A-I      intronic chr17:48783097(-) A-I      intronic chr17:48783204(-) A-I      intronic chr17:48783226(-) A-I      intronic chr17:48783579(-) A-I      intronic chr17:48777721(-) A-I      intronic chr17:48783215(-) A-I      intronic chr17:48782983(-) A-I      intronic chr17:48782206(-) A-I      intronic chr17:48783249(-) A-I      intronic chr17:48783629(-) A-I      intronic chr17:48781794(-) A-I      intronic chr17:48783201(-) A-I      intronic chr17:48782231(-) A-I      intronic chr17:48782982(-) A-I      intronic chr17:48782158(-) A-I      intronic chr17:48783094(-) A-I      intronic chr17:48782286(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ANKRD40	chr17:48783089(-) A-I intron -    22028664 chr17:48783090(-) A-I intron -    22028664 chr17:48783097(-) A-I intron -    22028664 chr17:48783115(-) A-I intron -    22028664 chr17:48783136(-) A-I intron -    22028664 chr17:48783154(-) A-I intron -    22028664 chr17:48783159(-) A-I intron -    22028664 chr17:48783176(-) A-I intron -    22028664 chr17:48783182(-) A-I intron -    22028664 chr17:48783186(-) A-I intron -    22028664 chr17:48783191(-) A-I intron -    22028664 chr17:48783195(-) A-I intron -    22028664 chr17:48783199(-) A-I intron -    22028664 chr17:48783201(-) A-I intron -    22028664 chr17:48783204(-) A-I intron -    22028664 chr17:48783215(-) A-I intron -    22028664 chr17:48783225(-) A-I intron -    22028664 chr17:48783226(-) A-I intron -    22028664 chr17:48783238(-) A-I intron -    22028664 chr17:48783249(-) A-I intron -    22028664 chr17:48783257(-) A-I intron -    22028664 chr17:48783262(-) A-I intron -    22028664 chr17:48783292(-) A-I intron -    22028664 chr17:48781863(-) A-G intron -    22484847 chr17:48782231(-) A-G intron -    22484847 chr17:48782232(-) A-G intron -    22484847 chr17:48782286(-) A-G intron -    22484847 chr17:48783118(-) A-G intron -    22484847 chr17:48783176(-) A-G intron -    22484847 chr17:48783199(-) A-G intron -    22484847 chr17:48783200(-) A-G intron -    22484847 chr17:48783579(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ANKRD40	chr17:48770786-48770787(-) Y 3'UTR       26075521 chr17:48771286-48771287(-) m6A 3'UTR       24209618 chr17:48771321-48771322(-) m6A 3'UTR       24209618 chr17:48772560-48772561(-) m6A 3'UTR       27773535 chr17:48772607-48772608(-) m6A 3'UTR       27773535 chr17:48772696-48772697(-) m6A 3'UTR       24284625//27773535//22608085 chr17:48772850-48772851(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:48772888-48772889(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:48772911-48772912(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:48772928-48772929(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:48773130-48773131(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:48773151-48773152(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:48773297-48773298(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:48773346-48773347(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:48773369-48773370(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:48773462-48773463(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:48776925-48776926(-) m6A CDS       24284625//27773535 chr17:48776942-48776943(-) m6A CDS       24284625//27773535 chr17:48777004-48777005(-) m6A CDS       24284625//27773535 chr17:48777017-48777018(-) m6A CDS       24284625//27773535 chr17:48777033-48777034(-) m6A CDS       24284625//27773535 chr17:48777189-48777190(-) m6A CDS       24981863//26404942//27773535 chr17:48777200-48777201(-) m1A CDS       26863196 chr17:48777247-48777248(-) m1A CDS       26863196 chr17:48777907-48777908(-) m6A exon//intron       24981863 chr17:48778021-48778022(-) Y 5'UTR//CDS//exon       26075521 chr17:48778047-48778048(-) m6A 5'UTR//CDS//exon       24209618//24981863//27773535 chr17:48778075-48778076(-) m6A 5'UTR//CDS//exon       24209618//24981863//27773535 chr17:48778174-48778175(-) m6A 5'UTR//intron       24209618 chr17:48784905-48784906(-) m6A CDS//exon       24209618//24981863 chr17:48784931-48784932(-) m6A CDS//exon       24209618//24981863 chr17:48784950-48784951(-) m6A CDS//exon       24209618//24981863 chr17:48785272-48785273(-) m6A 5'UTR       24981863//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ANKRD40	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ANKRD40

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.