Basic Information:

  VIRBase ID:  

VHID00514857

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          MIDN:  NM_177401     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	MIDN
miRBase Accession/Entrez ID	MIMAT0001581	90007
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	Stx

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MIDN	chr19:1256335(+) A-I      intronic chr19:1256649(+) A-I      intronic chr19:1256686(+) A-I      intronic chr19:1256695(+) A-I      intronic chr19:1256642(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MIDN	chr19:1248583-1248584(+) m6A 5'UTR       24209618//25456834//24981863 chr19:1248645-1248646(+) m6A 5'UTR       24209618//25456834//24981863 chr19:1250001-1250002(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828 chr19:1250152-1250153(+) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:1250202-1250203(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:1250524-1250525(+) m6A CDS       - chr19:1254322-1254323(+) m6A CDS       24284625 chr19:1254907-1254908(+) m6A CDS       24284625//24981863 chr19:1254995-1254996(+) m6A CDS       24284625 chr19:1255050-1255051(+) m6A CDS       24284625 chr19:1255444-1255445(+) m6A CDS       24284625 chr19:1255608-1255609(+) m6A CDS       24284625 chr19:1256996-1256997(+) m6A CDS       24284625//22575960 chr19:1257010-1257011(+) m6A CDS       24284625//22575960 chr19:1257017-1257018(+) m6A CDS       24284625 chr19:1257212-1257213(+) m6A CDS       24284625//24209618//24981863//22575960 chr19:1257324-1257325(+) m6A 3'UTR       24284625//24209618//24981863//22575960 chr19:1257461-1257462(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr19:1257763-1257764(+) m6A 3'UTR       26404942 chr19:1257786-1257787(+) m6A 3'UTR       26404942 chr19:1258032-1258033(+) m6A 3'UTR       24284625 chr19:1258074-1258075(+) m6A 3'UTR       24284625//24981863 chr19:1258143-1258144(+) m6A 3'UTR       24284625//24981863//26404942 chr19:1258181-1258182(+) m6A 3'UTR       25456834//24981863//26404942//27773535 chr19:1258274-1258275(+) m6A 3'UTR       24284625//25456834 chr19:1258854-1258855(+) m6A 3'UTR       27773535 chr19:1259068-1259069(+) m6A 3'UTR       27773535 chr19:1259093-1259094(+) m6A 3'UTR       27773535 chr19:1259125-1259126(+) m6A 3'UTR       27773535 chr19:1259137-1259138(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MIDN	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: MIDN

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.