Basic Information:

  VIRBase ID:  

VHID00514828

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ABCC10:  NR_146762     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ABCC10
miRBase Accession/Entrez ID	MIMAT0001581	89845
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	EST182763//MRP7//SIMRP7

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ABCC10	chr6:43414557(+) A-I      intronic chr6:43397701(+) A-I      intronic chr6:43397643(+) A-I      intronic chr6:43397628(+) A-I      intronic chr6:43397234(+) A-I      intronic chr6:43397707(+) A-I      intronic chr6:43397703(+) A-I      intronic chr6:43407718(+) A-I      intronic chr6:43407280(+) A-I      intronic chr6:43397544(+) A-I      intronic chr6:43407242(+) A-I      intronic chr6:43403226(+) A-I      intronic chr6:43398522(+) A-I      intronic chr6:43398482(+) A-I      intronic chr6:43398541(+) A-I      intronic chr6:43397915(+) A-I      intronic chr6:43407342(+) A-I      intronic chr6:43398561(+) A-I      intronic chr6:43397860(+) A-I      intronic chr6:43407759(+) A-I      intronic chr6:43398245(+) A-I      intronic chr6:43397994(+) A-I      intronic chr6:43398744(+) A-I      intronic chr6:43399368(+) A-I      intronic chr6:43397681(+) A-I      intronic chr6:43397661(+) A-I      intronic chr6:43397708(+) A-I      intronic chr6:43398659(+) A-I      intronic chr6:43397610(+) A-I      intronic chr6:43398103(+) A-I      intronic chr6:43397498(+) A-I      intronic chr6:43408352(+) A-I      intronic chr6:43397380(+) A-I      intronic chr6:43399264(+) A-I      intronic chr6:43398535(+) A-I      intronic chr6:43398486(+) A-I      intronic chr6:43409954(+) A-I      intronic chr6:43398560(+) A-I      intronic chr6:43397968(+) A-I      intronic chr6:43397439(+) A-I      intronic chr6:43397431(+) A-I      intronic chr6:43398736(+) A-I      intronic chr6:43399173(+) A-I      intronic chr6:43398514(+) A-I      intronic chr6:43397401(+) A-I      intronic chr6:43407795(+) A-I      intronic chr6:43397554(+) A-I      intronic chr6:43402993(+) A-I      intronic chr6:43408720(+) A-I      intronic chr6:43397909(+) A-I      intronic chr6:43399374(+) A-I      intronic chr6:43398578(+) A-I      intronic chr6:43397224(+) A-I      intronic chr6:43398540(+) A-I      intronic chr6:43407581(+) A-I      intronic chr6:43399361(+) A-I      intronic chr6:43397499(+) A-I      intronic chr6:43398601(+) A-I      intronic chr6:43407505(+) A-I      intronic chr6:43407354(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ABCC10	chr6:43397401(+) A-I intron -    22327324 chr6:43397439(+) A-I intron -    22327324 chr6:43397554(+) A-I intron -    22327324 chr6:43397610(+) A-I intron -    22327324 chr6:43397627(+) A-I intron -    22327324 chr6:43397635(+) A-I intron -    22327324 chr6:43397661(+) A-I intron -    22327324 chr6:43397890(+) A-I intron -    22327324 chr6:43397909(+) A-I intron -    22327324 chr6:43398034(+) A-I intron -    22327324 chr6:43398535(+) A-I intron -    22327324 chr6:43397401(+) A-G intron -    22484847 chr6:43397439(+) A-G intron -    22484847 chr6:43397482(+) A-G intron -    22484847 chr6:43397498(+) A-G intron -    22484847 chr6:43397499(+) A-G intron -    22484847 chr6:43397529(+) A-G intron -    22484847 chr6:43397554(+) A-G intron -    22484847 chr6:43397555(+) A-G intron -    22484847 chr6:43397610(+) A-G intron -    22484847 chr6:43397627(+) A-G intron -    22484847 chr6:43397635(+) A-G intron -    22484847 chr6:43397661(+) A-G intron -    22484847 chr6:43397708(+) A-G intron -    22484847 chr6:43397780(+) A-G intron -    22484847 chr6:43397860(+) A-G intron -    22484847 chr6:43397890(+) A-G intron -    22484847 chr6:43397903(+) A-G intron -    22484847 chr6:43397909(+) A-G intron -    22484847 chr6:43397915(+) A-G intron -    22484847 chr6:43397994(+) A-G intron -    22484847 chr6:43398026(+) A-G intron -    22484847 chr6:43398034(+) A-G intron -    22484847 chr6:43398090(+) A-G intron -    22484847 chr6:43398103(+) A-G intron -    22484847 chr6:43398486(+) A-G intron -    22484847 chr6:43398530(+) A-G intron -    22484847 chr6:43398540(+) A-G intron -    22484847 chr6:43398541(+) A-G intron -    22484847 chr6:43398560(+) A-G intron -    22484847 chr6:43398561(+) A-G intron -    22484847 chr6:43398578(+) A-G intron -    22484847 chr6:43398587(+) A-G intron -    22484847 chr6:43398659(+) A-G intron -    22484847 chr6:43398682(+) A-G intron -    22484847 chr6:43409954(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ABCC10	chr6:43395483-43395484(+) m6A 5'UTR//intron       24981863 chr6:43395627-43395628(+) m6A exon//intron       24981863 chr6:43395635-43395636(+) m6A exon//intron       24981863 chr6:43399965-43399966(+) m6A CDS//intron       24981863 chr6:43400005-43400006(+) m6A CDS//intron       24981863 chr6:43400299-43400300(+) m6A CDS//intron       24284625//25456834//24981863//22575960//22608085 chr6:43400308-43400309(+) m6A CDS//intron       24284625//25456834//24981863//22575960//22608085 chr6:43400347-43400348(+) m6A CDS//intron       24284625//25456834//24981863//22575960//22608085 chr6:43400361-43400362(+) Am CDS//intron       - chr6:43400454-43400455(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:43400476-43400477(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:43400584-43400585(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:43400603-43400604(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:43400799-43400800(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr6:43400862-43400863(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr6:43402608-43402609(+) m6A exon//intron       22608085 chr6:43402623-43402624(+) m6A exon//intron       22608085 chr6:43402640-43402641(+) m6A exon//intron       25456834//24981863//22608085 chr6:43402717-43402718(+) m6A exon//intron       25456834//24981863//22608085 chr6:43402726-43402727(+) m6A exon//intron       25456834//24981863//22608085 chr6:43411671-43411672(+) m6A CDS//exon       - chr6:43411731-43411732(+) m6A CDS//exon       - chr6:43411917-43411918(+) m6A CDS//exon       - chr6:43411928-43411929(+) m6A CDS//exon       - chr6:43413382-43413383(+) m6A CDS//exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ABCC10	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ABCC10

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.