Basic Information:

  VIRBase ID:  

VHID00514820

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          GAL3ST3:  NM_033036     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	GAL3ST3
miRBase Accession/Entrez ID	MIMAT0001581	89792
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	GAL3ST-3//GAL3ST2

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GAL3ST3	chr11:65809697-65809698(-) m6A 3'UTR       25456834 chr11:65809802-65809803(-) m6A 3'UTR       25456834 chr11:65809853-65809854(-) m6A 3'UTR       25456834 chr11:65810032-65810033(-) m6A CDS       25456834//24981863 chr11:65810095-65810096(-) m6A CDS       25456834//24981863 chr11:65810185-65810186(-) m6A CDS       25456834//24981863 chr11:65811031-65811032(-) m6A CDS       25456834//24981863 chr11:65811062-65811063(-) m6A CDS       25456834//24981863 chr11:65811106-65811107(-) m6A CDS       25456834//24981863 chr11:65812986-65812987(-) m6A 5'UTR//exon       - chr11:65813020-65813021(-) m6A 5'UTR//intron       - chr11:65816546-65816547(-) m6A 5'UTR//exon       25456834 chr11:65816565-65816566(-) m6A 5'UTR//exon       25456834

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: GAL3ST3

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.