Basic Information:

  VIRBase ID:  

VHID00514745

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          COL27A1:  NM_032888     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	COL27A1
miRBase Accession/Entrez ID	MIMAT0001581	85301
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	STLS

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	COL27A1	chr9:117042743(+) A-I      intronic chr9:117042744(+) A-I      intronic chr9:117064886(+) A-I      intronic chr9:117064895(+) A-I      intronic chr9:117064909(+) A-I      intronic chr9:117016225(+) A-I      intronic chr9:117042576(+) A-I      intronic chr9:117042583(+) A-I      intronic chr9:117064812(+) A-I      intronic chr9:117064938(+) A-I      intronic chr9:117041863(+) A-I      intronic chr9:117016190(+) A-I      intronic chr9:117016212(+) A-I      intronic chr9:117016243(+) A-I      intronic chr9:117016252(+) A-I      intronic chr9:117016265(+) A-I      intronic chr9:117016283(+) A-I      intronic chr9:117041910(+) A-I      intronic chr9:117041911(+) A-I      intronic chr9:117041912(+) A-I      intronic chr9:117042735(+) A-I      intronic chr9:117064879(+) A-I      intronic chr9:117064751(+) A-I      intronic chr9:116942394(+) A-I      intronic chr9:117015358(+) A-I      intronic chr9:117015363(+) A-I      intronic chr9:117015425(+) A-I      intronic chr9:117064752(+) A-I      intronic chr9:117015419(+) A-I      intronic chr9:116933883(+) A-I      intronic chr9:117065728(+) A-I      intronic chr9:116942380(+) A-I      intronic chr9:116933929(+) A-I      intronic chr9:116922642(+) A-I      intronic chr9:117041877(+) A-I      intronic chr9:116933861(+) A-I      intronic chr9:117015433(+) A-I      intronic chr9:117016226(+) A-I      intronic chr9:117015472(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	COL27A1	chr9:117010191(+) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	COL27A1	chr9:116930397-116930398(+) m6A CDS       24981863//22575960 chr9:116930442-116930443(+) m6A CDS       25456834//24981863//22575960 chr9:116930545-116930546(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:116930575-116930576(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:116930592-116930593(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:116930602-116930603(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:116930646-116930647(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:116930695-116930696(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:116930705-116930706(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:116930741-116930742(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:116930754-116930755(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:116930792-116930793(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:116931005-116931006(+) m6A CDS       24209618//24981863 chr9:116931120-116931121(+) m6A CDS       24284625//24209618//25456834//24981863 chr9:116931190-116931191(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr9:116931212-116931213(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr9:116931274-116931275(+) m6A CDS       24284625//24209618//24981863 chr9:116931389-116931390(+) m6A CDS       24209618//24981863 chr9:116931472-116931473(+) m6A CDS       24209618//25456834//24981863 chr9:116931508-116931509(+) m6A CDS       24209618//25456834//24981863 chr9:116931568-116931569(+) m6A CDS       24209618//25456834//24981863 chr9:116931590-116931591(+) m6A CDS       24209618//24981863 chr9:116958276-116958277(+) m6A CDS       - chr9:116967383-116967384(+) m6A CDS//intron       - chr9:116967401-116967402(+) m6A CDS//intron       - chr9:116967422-116967423(+) m6A CDS//intron       - chr9:116968049-116968050(+) m6A CDS//intron       - chr9:116968542-116968543(+) m6A CDS       - chr9:116984507-116984508(+) m6A CDS       - chr9:116993396-116993397(+) m6A CDS       - chr9:116994103-116994104(+) m6A CDS       - chr9:116994130-116994131(+) m6A CDS       - chr9:116997883-116997884(+) m6A 3'UTR//CDS       - chr9:116997927-116997928(+) m6A 3'UTR//CDS       - chr9:117004477-117004478(+) m6A 3'UTR//CDS//exon       - chr9:117027751-117027752(+) m6A 3'UTR//CDS       - chr9:117031498-117031499(+) m6A exon//intron       - chr9:117031531-117031532(+) m6A 3'UTR//CDS//exon       25456834 chr9:117033045-117033046(+) m6A 3'UTR//CDS//exon       25456834 chr9:117033091-117033092(+) m6A exon//intron       - chr9:117036433-117036434(+) m6A exon//intron       - chr9:117037944-117037945(+) m6A 3'UTR//CDS       25456834 chr9:117037953-117037954(+) m6A 3'UTR//CDS       25456834 chr9:117037972-117037973(+) m6A 3'UTR//CDS       25456834 chr9:117044756-117044757(+) m6A 3'UTR//CDS       24209618//25456834//24981863 chr9:117044785-117044786(+) m6A 3'UTR//CDS       24209618//24981863 chr9:117044792-117044793(+) m6A 3'UTR//CDS       24209618//24981863 chr9:117044837-117044838(+) m6A 3'UTR//CDS       24209618//24981863 chr9:117046020-117046021(+) m6A 3'UTR//CDS       24981863 chr9:117046026-117046027(+) m6A 3'UTR//CDS       24981863 chr9:117047005-117047006(+) m6A 3'UTR//CDS       24981863 chr9:117047023-117047024(+) m6A 3'UTR//CDS       24981863 chr9:117047032-117047033(+) m6A 3'UTR//CDS       24209618//24981863 chr9:117047041-117047042(+) m6A 3'UTR//CDS       24209618//24981863 chr9:117051003-117051004(+) m6A 3'UTR//CDS       24209618//25456834//24981863 chr9:117051013-117051014(+) m6A 3'UTR//CDS       24209618//25456834//24981863 chr9:117051021-117051022(+) m6A 3'UTR//CDS       24209618//25456834//24981863 chr9:117051195-117051196(+) m6A 3'UTR//CDS       24209618//25456834//24981863 chr9:117051532-117051533(+) m6A 3'UTR//CDS       25456834//27773536 chr9:117051550-117051551(+) m6A 3'UTR//CDS       25456834//24981863//27773536 chr9:117052339-117052340(+) m6A 3'UTR//CDS       25456834//24981863//27773536 chr9:117052544-117052545(+) m6A 3'UTR//CDS       24209618//25456834//24981863 chr9:117052568-117052569(+) m6A 3'UTR//CDS       24209618//25456834 chr9:117052604-117052605(+) m6A 3'UTR//CDS       24209618//25456834 chr9:117053111-117053112(+) m6A 3'UTR//CDS       24209618//25456834 chr9:117053181-117053182(+) m6A 3'UTR//CDS       24209618//25456834 chr9:117054402-117054403(+) m6A 3'UTR//CDS       24209618//25456834 chr9:117054430-117054431(+) m6A 3'UTR//CDS       24209618//25456834 chr9:117054458-117054459(+) m6A 3'UTR//CDS       24209618//25456834 chr9:117062396-117062397(+) m6A 3'UTR//CDS       24209618 chr9:117068743-117068744(+) m6A exon//intron       - chr9:117068755-117068756(+) m6A exon//intron       - chr9:117068761-117068762(+) m6A exon//intron       - chr9:117068815-117068816(+) m6A 3'UTR//CDS//exon       - chr9:117068830-117068831(+) m6A 3'UTR//CDS//exon       - chr9:117068853-117068854(+) m6A 3'UTR//CDS//exon       - chr9:117071659-117071660(+) m6A 3'UTR//CDS//exon       - chr9:117071700-117071701(+) m6A 3'UTR//CDS//exon       - chr9:117072956-117072957(+) m6A 3'UTR//CDS//exon       25456834 chr9:117073097-117073098(+) m6A 3'UTR//exon       - chr9:117073161-117073162(+) m6A 3'UTR//exon       - chr9:117073188-117073189(+) m6A 3'UTR//exon       - chr9:117073219-117073220(+) m6A 3'UTR//exon       - chr9:117073385-117073386(+) m6A 3'UTR//exon       24981863//27773535 chr9:117073410-117073411(+) m6A 3'UTR//exon       24981863//27773535 chr9:117073437-117073438(+) m6A 3'UTR//exon       24981863//27773535 chr9:117073679-117073680(+) m6A 3'UTR//exon       24981863//27773535 chr9:117073690-117073691(+) m6A 3'UTR//exon       24981863//27773535 chr9:117073850-117073851(+) m6A 3'UTR       24981863//27773535//22608085 chr9:117073856-117073857(+) m6A 3'UTR       24981863//27773535//22608085 chr9:117073862-117073863(+) m6A 3'UTR       24981863//27773535//22608085 chr9:117073868-117073869(+) m6A 3'UTR       24981863//27773535//22608085 chr9:117073880-117073881(+) m6A 3'UTR       24981863//27773535//22608085 chr9:117073915-117073916(+) m6A 3'UTR       24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	COL27A1	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: COL27A1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.