Basic Information:

  VIRBase ID:  

VHID00514696

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SERAC1:  NR_073096     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SERAC1
miRBase Accession/Entrez ID	MIMAT0001581	84947
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SERAC1	chr6:158568335(-) A-I      intronic chr6:158568344(-) A-I      intronic chr6:158568347(-) A-I      intronic chr6:158568349(-) A-I      intronic chr6:158560061(-) A-I      intronic chr6:158560042(-) A-I      intronic chr6:158560055(-) A-I      intronic chr6:158560064(-) A-I      intronic chr6:158554566(-) A-I      intronic chr6:158578232(-) A-I      intronic chr6:158572381(-) A-I      intronic chr6:158572526(-) A-I      intronic chr6:158572550(-) A-I      intronic chr6:158578248(-) A-I      intronic chr6:158578256(-) A-I      intronic chr6:158578260(-) A-I      intronic chr6:158560072(-) A-I      intronic chr6:158580344(-) A-I      intronic chr6:158554529(-) A-I      intronic chr6:158554582(-) A-I      intronic chr6:158580448(-) A-I      intronic chr6:158554558(-) A-I      intronic chr6:158554690(-) A-I      intronic chr6:158554521(-) A-I      intronic chr6:158554494(-) A-I      intronic chr6:158550814(-) A-I      intronic chr6:158556401(-) A-I      intronic chr6:158566057(-) A-I      intronic chr6:158566750(-) A-I      intronic chr6:158568295(-) A-I      intronic chr6:158569603(-) A-I      intronic chr6:158569612(-) A-I      intronic chr6:158569731(-) A-I      intronic chr6:158557665(-) A-I      intronic chr6:158568346(-) A-I      intronic chr6:158580468(-) A-I      intronic chr6:158554199(-) A-I      intronic chr6:158573154(-) A-I      intronic chr6:158568354(-) A-I      intronic chr6:158539550(-) A-I      intronic chr6:158566620(-) A-I      intronic chr6:158531302(-) A-I      3'UTR chr6:158557114(-) A-I      intronic chr6:158566642(-) A-I      intronic chr6:158563614(-) A-I      intronic chr6:158566707(-) A-I      intronic chr6:158554654(-) A-I      intronic chr6:158568262(-) A-I      intronic chr6:158573198(-) A-I      intronic chr6:158573233(-) A-I      intronic chr6:158572489(-) A-I      intronic chr6:158572987(-) A-I      intronic chr6:158554183(-) A-I      intronic chr6:158577134(-) A-I      intronic chr6:158554635(-) A-I      intronic chr6:158560060(-) A-I      intronic chr6:158580859(-) A-I      intronic chr6:158580824(-) A-I      intronic chr6:158580748(-) A-I      intronic chr6:158566689(-) A-I      intronic chr6:158560103(-) A-I      intronic chr6:158572447(-) A-I      intronic chr6:158580717(-) A-I      intronic chr6:158572452(-) A-I      intronic chr6:158573008(-) A-I      intronic chr6:158580874(-) A-I      intronic chr6:158580370(-) A-I      intronic chr6:158580836(-) A-I      intronic chr6:158566216(-) A-I      intronic chr6:158580821(-) A-I      intronic chr6:158560056(-) A-I      intronic chr6:158573245(-) A-I      intronic chr6:158580795(-) A-I      intronic chr6:158567646(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SERAC1	chr6:158543650(-) A-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SERAC1	chr6:158530564-158530565(-) m6A 3'UTR       27773535 chr6:158530604-158530605(-) m6A 3'UTR       27773535 chr6:158530635-158530636(-) m6A 3'UTR       27773535 chr6:158531854-158531855(-) m6A 3'UTR       22608085 chr6:158531961-158531962(-) m6A 3'UTR       24981863//27773535//22608085 chr6:158531970-158531971(-) m6A 3'UTR       24981863//27773535//22608085 chr6:158531976-158531977(-) m6A 3'UTR       24209618//25456834//24981863//27773535//22608085 chr6:158532256-158532257(-) m6A 3'UTR       24209618//24981863//27773535//27371828//22608085 chr6:158532264-158532265(-) m6A 3'UTR       24209618//24981863//27773535//27371828//22608085 chr6:158532307-158532308(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr6:158532352-158532353(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr6:158532401-158532402(-) m6A 3'UTR//CDS       24209618//24981863//27773535//22608085 chr6:158532410-158532411(-) m6A 3'UTR//CDS       24209618//24981863//27773535//22608085 chr6:158532488-158532489(-) m6A 3'UTR//CDS       24981863//27773535//22608085 chr6:158534540-158534541(-) m6A 3'UTR//CDS       22608085 chr6:158534566-158534567(-) m6A 3'UTR//CDS       22608085 chr6:158534572-158534573(-) m6A 3'UTR//CDS       22608085 chr6:158540085-158540086(-) m6A 3'UTR//CDS       27773535 chr6:158540102-158540103(-) m6A 3'UTR//CDS       27773535 chr6:158540127-158540128(-) m6A 3'UTR//CDS       27773535 chr6:158540143-158540144(-) m6A 3'UTR//CDS       27773535 chr6:158541460-158541461(-) m6A 3'UTR//CDS       27773535 chr6:158541514-158541515(-) m6A 3'UTR//CDS       27773535 chr6:158541522-158541523(-) m6A 3'UTR//CDS       27773535 chr6:158579349-158579350(-) m6A CDS       27371828//27773536 chr6:158579453-158579454(-) m6A 5'UTR//intron       27371828//27773536 chr6:158580196-158580197(-) m6A 5'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SERAC1	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SERAC1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.