Basic Information:

  VIRBase ID:  

VHID00514682

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          RAB2B:  NR_028074     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	RAB2B
miRBase Accession/Entrez ID	MIMAT0001581	84932
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RAB2B	chr14:21939739(-) A-I      intronic chr14:21942337(-) A-I      intronic chr14:21939733(-) A-I      intronic chr14:21942268(-) A-I      intronic chr14:21942267(-) A-I      intronic chr14:21942263(-) A-I      intronic chr14:21939730(-) A-I      intronic chr14:21928878(-) A-I      3'UTR chr14:21939596(-) A-I      intronic chr14:21939572(-) A-I      intronic chr14:21938244(-) A-I      intronic chr14:21928966(-) A-I      3'UTR chr14:21928687(-) A-I      3'UTR chr14:21928976(-) A-I      3'UTR chr14:21942250(-) A-I      intronic chr14:21928856(-) A-I      3'UTR chr14:21942281(-) A-I      intronic chr14:21942311(-) A-I      intronic chr14:21928481(-) A-I      NonSyn:Stp->Trp chr14:21928501(-) A-I      NonSyn:Ser->Gly chr14:21929880(-) A-I      intronic chr14:21929868(-) A-I      intronic chr14:21938322(-) A-I      intronic chr14:21934624(-) A-I      intronic chr14:21933117(-) A-I      intronic chr14:21938272(-) A-I      intronic chr14:21935162(-) A-I      intronic chr14:21939102(-) A-I      intronic chr14:21933151(-) A-I      intronic chr14:21941129(-) A-I      intronic chr14:21938307(-) A-I      intronic chr14:21938226(-) A-I      intronic chr14:21932477(-) A-I      intronic chr14:21930720(-) A-I      intronic chr14:21939682(-) A-I      intronic chr14:21935171(-) A-I      intronic chr14:21942049(-) A-I      intronic chr14:21929892(-) A-I      intronic chr14:21939750(-) A-I      intronic chr14:21938118(-) A-I      intronic chr14:21935338(-) A-I      intronic chr14:21935210(-) A-I      intronic chr14:21941116(-) A-I      intronic chr14:21942059(-) A-I      intronic chr14:21932367(-) A-I      intronic chr14:21940029(-) A-I      intronic chr14:21940017(-) A-I      intronic chr14:21940013(-) A-I      intronic chr14:21939141(-) A-I      intronic chr14:21939967(-) A-I      intronic chr14:21939946(-) A-I      intronic chr14:21939573(-) A-I      intronic chr14:21939571(-) A-I      intronic chr14:21929878(-) A-I      intronic chr14:21939250(-) A-I      intronic chr14:21939104(-) A-I      intronic chr14:21935204(-) A-I      intronic chr14:21939087(-) A-I      intronic chr14:21939862(-) A-I      intronic chr14:21938384(-) A-I      intronic chr14:21934615(-) A-I      intronic chr14:21938308(-) A-I      intronic chr14:21939246(-) A-I      intronic chr14:21938200(-) A-I      intronic chr14:21938282(-) A-I      intronic chr14:21938276(-) A-I      intronic chr14:21941159(-) A-I      intronic chr14:21928869(-) A-I      3'UTR chr14:21928865(-) A-I      3'UTR chr14:21928894(-) A-I      3'UTR chr14:21928576(-) A-I      3'UTR chr14:21928841(-) A-I      3'UTR chr14:21928838(-) A-I      3'UTR chr14:21928516(-) A-I      3'UTR chr14:21928697(-) A-I      3'UTR chr14:21928729(-) A-I      3'UTR chr14:21928609(-) A-I      3'UTR chr14:21928911(-) A-I      3'UTR chr14:21928625(-) A-I      3'UTR chr14:21928681(-) A-I      3'UTR chr14:21928910(-) A-I      3'UTR chr14:21928881(-) A-I      3'UTR chr14:21928620(-) A-I      3'UTR chr14:21928606(-) A-I      3'UTR chr14:21928739(-) A-I      3'UTR chr14:21928711(-) A-I      3'UTR chr14:21928564(-) A-I      3'UTR chr14:21928604(-) A-I      3'UTR chr14:21928802(-) A-I      3'UTR chr14:21929028(-) A-I      3'UTR chr14:21928941(-) A-I      3'UTR chr14:21928572(-) A-I      3'UTR chr14:21928587(-) A-I      3'UTR chr14:21928662(-) A-I      3'UTR chr14:21928975(-) A-I      3'UTR chr14:21929022(-) A-I      3'UTR chr14:21928851(-) A-I      3'UTR chr14:21928661(-) A-I      3'UTR chr14:21928552(-) A-I      3'UTR chr14:21928905(-) A-I      3'UTR chr14:21928532(-) A-I      3'UTR chr14:21928845(-) A-I      3'UTR chr14:21928578(-) A-I      3'UTR chr14:21928502(-) A-I      Syn:Gln->Gln chr14:21928490(-) A-I      Syn:Leu->Leu chr14:21932960(-) A-I      intronic chr14:21939210(-) A-I      intronic chr14:21938249(-) A-I      intronic chr14:21939655(-) A-I      intronic chr14:21942228(-) A-I      intronic chr14:21939557(-) A-I      intronic chr14:21931478(-) A-I      intronic chr14:21932520(-) A-I      intronic chr14:21940008(-) A-I      intronic chr14:21939873(-) A-I      intronic chr14:21939558(-) A-I      intronic chr14:21939708(-) A-I      intronic chr14:21933062(-) A-I      intronic chr14:21930836(-) A-I      intronic chr14:21940107(-) A-I      intronic chr14:21941107(-) A-I      intronic chr14:21932316(-) A-I      intronic chr14:21939755(-) A-I      intronic chr14:21930886(-) A-I      intronic chr14:21942007(-) A-I      intronic chr14:21933122(-) A-I      intronic chr14:21935177(-) A-I      intronic chr14:21939629(-) A-I      intronic chr14:21939963(-) A-I      intronic chr14:21939065(-) A-I      intronic chr14:21939064(-) A-I      intronic chr14:21929971(-) A-I      intronic chr14:21942316(-) A-I      intronic chr14:21934476(-) A-I      intronic chr14:21939691(-) A-I      intronic chr14:21933077(-) A-I      intronic chr14:21939619(-) A-I      intronic chr14:21930915(-) A-I      intronic chr14:21939584(-) A-I      intronic chr14:21941874(-) A-I      intronic chr14:21939318(-) A-I      intronic chr14:21939293(-) A-I      intronic chr14:21940081(-) A-I      intronic chr14:21931622(-) A-I      intronic chr14:21933040(-) A-I      intronic chr14:21939249(-) A-I      intronic chr14:21939608(-) A-I      intronic chr14:21940007(-) A-I      intronic chr14:21942222(-) A-I      intronic chr14:21938346(-) A-I      intronic chr14:21931544(-) A-I      intronic chr14:21943753(-) A-I      intronic chr14:21939546(-) A-I      intronic chr14:21939291(-) A-I      intronic chr14:21932959(-) A-I      intronic chr14:21941982(-) A-I      intronic chr14:21935261(-) A-I      intronic chr14:21942004(-) A-I      intronic chr14:21931580(-) A-I      intronic chr14:21939665(-) A-I      intronic chr14:21939931(-) A-I      intronic chr14:21939593(-) A-I      intronic chr14:21938183(-) A-I      intronic chr14:21941871(-) A-I      intronic chr14:21938178(-) A-I      intronic chr14:21941133(-) A-I      intronic chr14:21939144(-) A-I      intronic chr14:21943687(-) A-I      intronic chr14:21939052(-) A-I      intronic chr14:21930877(-) A-I      intronic chr14:21939973(-) A-I      intronic chr14:21939972(-) A-I      intronic chr14:21940028(-) A-I      intronic chr14:21938313(-) A-I      intronic chr14:21941915(-) A-I      intronic chr14:21938207(-) A-I      intronic chr14:21939724(-) A-I      intronic chr14:21939220(-) A-I      intronic chr14:21938250(-) A-I      intronic chr14:21939695(-) A-I      intronic chr14:21928706(-) A-I      3'UTR chr14:21928840(-) A-I      3'UTR chr14:21929045(-) A-I      3'UTR chr14:21929004(-) A-I      3'UTR chr14:21928658(-) A-I      3'UTR chr14:21928700(-) A-I      3'UTR chr14:21928888(-) A-I      3'UTR chr14:21928960(-) A-I      3'UTR chr14:21929036(-) A-I      3'UTR chr14:21928999(-) A-I      3'UTR chr14:21928622(-) A-I      3'UTR chr14:21928940(-) A-I      3'UTR chr14:21928998(-) A-I      3'UTR chr14:21928901(-) A-I      3'UTR chr14:21929060(-) A-I      3'UTR chr14:21928955(-) A-I      3'UTR chr14:21928948(-) A-I      3'UTR chr14:21929044(-) A-I      3'UTR chr14:21928996(-) A-I      3'UTR chr14:21928644(-) A-I      3'UTR chr14:21928675(-) A-I      3'UTR chr14:21929014(-) A-I      3'UTR chr14:21928889(-) A-I      3'UTR chr14:21928945(-) A-I      3'UTR chr14:21928884(-) A-I      3'UTR chr14:21928846(-) A-I      3'UTR chr14:21928857(-) A-I      3'UTR chr14:21928942(-) A-I      3'UTR chr14:21928943(-) A-I      3'UTR chr14:21928524(-) A-I      3'UTR chr14:21928668(-) A-I      3'UTR chr14:21928985(-) A-I      3'UTR chr14:21928835(-) A-I      3'UTR chr14:21928561(-) A-I      3'UTR chr14:21928632(-) A-I      3'UTR chr14:21928682(-) A-I      3'UTR chr14:21928937(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RAB2B	chr14:21928490(-) A-I exon 3'UTR    22327324 chr14:21928501(-) A-I exon 3'UTR    22327324 chr14:21928622(-) A-I exon 3'UTR    21960545   //22327324 chr14:21928632(-) A-I exon 3'UTR    22327324 chr14:21928682(-) A-I exon 3'UTR    22327324 chr14:21928700(-) A-I exon 3'UTR    22327324 chr14:21928706(-) A-I exon 3'UTR    22327324 chr14:21928840(-) A-I exon 3'UTR    21960545   //22327324 chr14:21928846(-) A-I exon 3'UTR    22327324 chr14:21928851(-) A-I exon 3'UTR    21960545   //22327324 chr14:21928910(-) A-I exon 3'UTR    21960545   //22327324 chr14:21928911(-) A-I exon 3'UTR    22327324 chr14:21928996(-) A-I exon 3'UTR    22327324 chr14:21928998(-) A-I exon 3'UTR    21960545   //22327324 chr14:21929014(-) A-I exon 3'UTR    22327324 chr14:21929044(-) A-I exon 3'UTR    21960545   //22327324 chr14:21928501(-) A-G exon 3'UTR    21725310 chr14:21928490(-) A-G exon 3'UTR    22484847 chr14:21928502(-) A-G exon 3'UTR    22484847 chr14:21928578(-) A-G exon 3'UTR    22484847 chr14:21928622(-) A-G exon 3'UTR    22484847 chr14:21928632(-) A-G exon 3'UTR    22484847 chr14:21928658(-) A-G exon 3'UTR    22484847 chr14:21928668(-) A-G exon 3'UTR    22484847 chr14:21928681(-) A-G exon 3'UTR    22484847 chr14:21928682(-) A-G exon 3'UTR    22484847 chr14:21928700(-) A-G exon 3'UTR    22484847 chr14:21928840(-) A-G exon 3'UTR    22484847 chr14:21928846(-) A-G exon 3'UTR    22484847 chr14:21928851(-) A-G exon 3'UTR    22484847 chr14:21928865(-) A-G exon 3'UTR    22484847 chr14:21928889(-) A-G exon 3'UTR    22484847 chr14:21928910(-) A-G exon 3'UTR    22484847 chr14:21928911(-) A-G exon 3'UTR    22484847 chr14:21928940(-) A-G exon 3'UTR    22484847 chr14:21928941(-) A-G exon 3'UTR    22484847 chr14:21928955(-) A-G exon 3'UTR    22484847 chr14:21928996(-) A-G exon 3'UTR    22484847 chr14:21928998(-) A-G exon 3'UTR    22484847 chr14:21928999(-) A-G exon 3'UTR    22484847 chr14:21929014(-) A-G exon 3'UTR    22484847 chr14:21929044(-) A-G exon 3'UTR    22484847 chr14:21929045(-) A-G exon 3'UTR    22484847 chr14:21939220(-) A-G intron -    22484847 chr14:21939318(-) A-G intron -    22484847 chr14:21939584(-) A-G intron -    22484847 chr14:21939655(-) A-G intron -    22484847 chr14:21939682(-) A-G intron -    22484847 chr14:21939755(-) A-G intron -    22484847 chr14:21939972(-) A-G intron -    22484847 chr14:21939973(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RAB2B	chr14:21927559-21927560(-) m6A 3'UTR       27773535 chr14:21927566-21927567(-) m6A 3'UTR       27773535 chr14:21927578-21927579(-) m6A 3'UTR       27773535 chr14:21927596-21927597(-) m6A 3'UTR       27773535 chr14:21929340-21929341(-) m6A 3'UTR//intron       24981863 chr14:21929353-21929354(-) m6A 3'UTR//intron       24981863 chr14:21929391-21929392(-) m6A 3'UTR//CDS//intron       24981863 chr14:21929411-21929412(-) m6A 3'UTR//CDS//exon       24981863 chr14:21942745-21942746(-) m6A exon//intron       - chr14:21942937-21942938(-) m6A exon//intron       27773535 chr14:21944990-21944991(-) m6A CDS//exon       24981863//27773535 chr14:21945049-21945050(-) m6A 5'UTR//exon       24981863 chr14:21945056-21945057(-) m6A 5'UTR//exon       24981863 chr14:21945119-21945120(-) m1A 5'UTR       26863196

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RAB2B	Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: RAB2B

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.