Basic Information:

  VIRBase ID:  

VHID00514647

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ADO:  NM_032804     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ADO
miRBase Accession/Entrez ID	MIMAT0001581	84890
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	C10orf22

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ADO	chr10:64564760-64564761(+) m6A 5'UTR       24209618//25456834//27371828//27773536 chr10:64564829-64564830(+) m6A CDS       24284625//24209618//25456834//27371828//27773536 chr10:64564967-64564968(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr10:64565012-64565013(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr10:64565018-64565019(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr10:64565219-64565220(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr10:64565387-64565388(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:64565435-64565436(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:64565474-64565475(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:64565566-64565567(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:64565601-64565602(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:64565778-64565779(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr10:64565887-64565888(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr10:64566425-64566426(+) m6A 3'UTR       24981863 chr10:64566852-64566853(+) m6A 3'UTR       26404942 chr10:64566864-64566865(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ADO	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ADO

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.