Basic Information:

  VIRBase ID:  

VHID00514516

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PARD6B:  NM_032521     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PARD6B
miRBase Accession/Entrez ID	MIMAT0001581	84612
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	PAR6B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PARD6B	chr20:49357637(+) A-I      intronic chr20:49353437(+) A-I      intronic chr20:49353395(+) A-I      intronic chr20:49351511(+) A-I      intronic chr20:49351320(+) A-I      intronic chr20:49355823(+) A-I      intronic chr20:49351024(+) A-I      intronic chr20:49355822(+) A-I      intronic chr20:49351022(+) A-I      intronic chr20:49351425(+) A-I      intronic chr20:49372363(+) A-I      intronic chr20:49365181(+) A-I      intronic chr20:49364638(+) A-I      intronic chr20:49364614(+) A-I      intronic chr20:49362305(+) A-I      intronic chr20:49360305(+) A-I      intronic chr20:49360170(+) A-I      intronic chr20:49358717(+) A-I      intronic chr20:49358660(+) A-I      intronic chr20:49358641(+) A-I      intronic chr20:49358629(+) A-I      intronic chr20:49355864(+) A-I      intronic chr20:49351454(+) A-I      intronic chr20:49355837(+) A-I      intronic chr20:49372439(+) A-I      intronic chr20:49372444(+) A-I      intronic chr20:49360315(+) A-I      intronic chr20:49355831(+) A-I      intronic chr20:49355819(+) A-I      intronic chr20:49355807(+) A-I      intronic chr20:49353418(+) A-I      intronic chr20:49353364(+) A-I      intronic chr20:49353312(+) A-I      intronic chr20:49353299(+) A-I      intronic chr20:49353291(+) A-I      intronic chr20:49351632(+) A-I      intronic chr20:49351608(+) A-I      intronic chr20:49351607(+) A-I      intronic chr20:49372434(+) A-I      intronic chr20:49360214(+) A-I      intronic chr20:49351293(+) A-I      intronic chr20:49353496(+) A-I      intronic chr20:49360217(+) A-I      intronic chr20:49351556(+) A-I      intronic chr20:49370830(+) A-I      intronic chr20:49350945(+) A-I      intronic chr20:49351567(+) A-I      intronic chr20:49353487(+) A-I      intronic chr20:49360237(+) A-I      intronic chr20:49357772(+) A-I      intronic chr20:49350937(+) A-I      intronic chr20:49365176(+) A-I      intronic chr20:49365786(+) A-I      intronic chr20:49349951(+) A-I      intronic chr20:49368157(+) A-I      3'UTR chr20:49364766(+) A-I      intronic chr20:49365603(+) A-I      intronic chr20:49360781(+) A-I      intronic chr20:49362318(+) A-I      intronic chr20:49365356(+) A-I      intronic chr20:49353308(+) A-I      intronic chr20:49365702(+) A-I      intronic chr20:49365291(+) A-I      intronic chr20:49365349(+) A-I      intronic chr20:49351501(+) A-I      intronic chr20:49362176(+) A-I      intronic chr20:49349776(+) A-I      intronic chr20:49361809(+) A-I      intronic chr20:49360171(+) A-I      intronic chr20:49360791(+) A-I      intronic chr20:49365721(+) A-I      intronic chr20:49355374(+) A-I      intronic chr20:49358764(+) A-I      intronic chr20:49351566(+) A-I      intronic chr20:49372457(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PARD6B	chr20:49349747(+) A-I intron -    21960545 chr20:49351017(+) A-I intron -    21960545 chr20:49351022(+) A-I intron -    21960545 chr20:49351241(+) A-I intron -    21960545 chr20:49351293(+) A-I intron -    21960545 chr20:49351567(+) A-I intron -    21960545 chr20:49355420(+) A-I intron -    21960545 chr20:49362282(+) A-I intron -    21960545 chr20:49362305(+) A-I intron -    21960545 chr20:49362306(+) A-I intron -    21960545 chr20:49365291(+) A-I intron -    21960545 chr20:49365349(+) A-G intron -    22484847 chr20:49365689(+) G-C intron -    22484847 chr20:49365702(+) A-G intron -    22484847 chr20:49365721(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PARD6B	chr20:49348327-49348328(+) m6A CDS       - chr20:49354434-49354435(+) m6A CDS       22608085 chr20:49354517-49354518(+) m6A CDS       24981863//22608085 chr20:49354529-49354530(+) m6A CDS       24981863//22608085 chr20:49366204-49366205(+) m6A CDS//intron       24284625//24981863//22608085 chr20:49366225-49366226(+) m6A CDS//intron       24284625//24981863//22608085 chr20:49366318-49366319(+) m6A CDS//intron       24284625//24981863//22608085 chr20:49366325-49366326(+) m6A CDS//intron       24284625//24981863//22608085 chr20:49366406-49366407(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr20:49366526-49366527(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366603-49366604(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366646-49366647(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366654-49366655(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366678-49366679(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366686-49366687(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366748-49366749(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366774-49366775(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366804-49366805(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366895-49366896(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366954-49366955(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366968-49366969(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366988-49366989(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49367007-49367008(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49367026-49367027(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr20:49367066-49367067(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr20:49367192-49367193(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr20:49367226-49367227(+) m6A 3'UTR//intron       24981863//22608085 chr20:49367307-49367308(+) m6A 3'UTR//intron       22608085 chr20:49367320-49367321(+) m6A 3'UTR//intron       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PARD6B	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PARD6B

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.