Detail Information

Basic Information:


  VIRBase ID:  

VHID00514485

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           JPH4:      

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Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p JPH4
miRBase
Accession/Entrez ID		 MIMAT0001581 84502
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - JP4//JPHL1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR JPH4
chr14:24044033(-) A-I      intronic
chr14:24043548(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase JPH4
chr14:24040415-24040416(-) m6A CDS       24209618//25456834//24981863//27371828
chr14:24040485-24040486(-) m6A CDS       24209618//25456834//24981863
chr14:24040562-24040563(-) m6A CDS       24209618//25456834//24981863
chr14:24040589-24040590(-) m6A CDS       24209618//25456834//24981863
chr14:24040614-24040615(-) m6A CDS       24209618//25456834//24981863
chr14:24040650-24040651(-) m6A CDS       24209618//25456834
chr14:24040661-24040662(-) m6A CDS       24209618//25456834
chr14:24041036-24041037(-) m6A CDS       24209618
chr14:24041050-24041051(-) m6A CDS       24209618
chr14:24044962-24044963(-) m6A CDS//exon       -
chr14:24045276-24045277(-) m6A CDS//exon       24209618//25456834
chr14:24046298-24046299(-) m6A CDS//exon       24209618//25456834
chr14:24046488-24046489(-) m6A CDS//exon       24209618//25456834//24981863
chr14:24047702-24047703(-) m6A 5'UTR//exon       -
chr14:24047782-24047783(-) m6A 5'UTR       -
chr14:24047920-24047921(-) m6A 5'UTR       -
chr14:24047944-24047945(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate JPH4
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: JPH4

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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