Detail Information

Basic Information:


  VIRBase ID:  

VHID00514468

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           SYVN1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p SYVN1
miRBase
Accession/Entrez ID		 MIMAT0001581 84447
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - DER3//HRD1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SYVN1
chr11:64901459(-) A-I      intronic
chr11:64896391(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SYVN1
chr11:64889370-64889371(-) m6A intron       24284625//25456834//24981863//27773535//27371828//22575960
chr11:64889439-64889440(-) m6A intron       27371828
chr11:64889487-64889488(-) m6A intron       27371828
chr11:64889572-64889573(-) m6A exon       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:64889674-64889675(-) m6A exon       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:64889703-64889704(-) m6A exon       25456834//24981863//27773535//27371828//27773536
chr11:64889833-64889834(-) m6A exon       24284625//25456834//24981863//22608085
chr11:64889867-64889868(-) m6A exon       24284625//25456834//24981863//22608085
chr11:64894763-64894764(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22608085
chr11:64895181-64895182(-) m6A 3'UTR//exon//intron       24284625
chr11:64895235-64895236(-) m6A 3'UTR//exon//intron       24284625//24209618//27773535//22575960
chr11:64895397-64895398(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:64895422-64895423(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:64895451-64895452(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:64895480-64895481(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:64895800-64895801(-) m6A 3'UTR//exon//intron       24284625//27773535
chr11:64896145-64896146(-) m6A CDS//exon//intron       24284625//27773535
chr11:64897407-64897408(-) m6A exon//intron       24284625//27773535
chr11:64898263-64898264(-) m6A CDS//exon       27773535
chr11:64898419-64898420(-) m6A CDS//exon       27773535
chr11:64898468-64898469(-) m6A 3'UTR//CDS//exon       27773535
chr11:64898608-64898609(-) m6A 3'UTR//CDS//exon       27773535
chr11:64899794-64899795(-) m6A CDS//exon//intron       27773535
chr11:64899878-64899879(-) m6A exon//intron       27773535
chr11:64900396-64900397(-) m6A CDS//exon       27773535
chr11:64900405-64900406(-) m6A CDS//exon       27773535
chr11:64900508-64900509(-) m6A CDS//exon       27773535
chr11:64901799-64901800(-) m6A 5'UTR//intron       24981863
chr11:64901876-64901877(-) m6A 5'UTR//intron       24981863
chr11:64901882-64901883(-) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SYVN1
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: SYVN1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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